期刊
BRITISH JOURNAL OF CANCER
卷 104, 期 3, 页码 480-487出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6606055
关键词
CXCL1; CXCL8; CXCR1; CXCR2; colorectal cancer
类别
资金
- Public Health Agency [EAT/3472/06] Funding Source: researchfish
BACKGROUND: The CXC-chemokine expression is linked with colorectal cancer (CRC) progression but their significance in resected CRC is unclear. We explored the prognostic impact of such expression in stage II and III CRC. METHODS: Tissue microarrays were constructed from stage II and III CRC biopsies (n = 254), and the expression of CXCL1 and CXCL8, and their receptors CXCR1 and CXCR2, in malignant and adjacent normal tissue was graded by immunohistochemistry and was correlated with prognostic factors. RESULTS: Expression of CXCL1, CXCR1 and CXCR2 was elevated in tumour epithelium relative to normal adjacent tissue (P < 0.001). CXCL8 expression was detectable in the peritumoural inflammatory infiltrate. There was no overall association between CXCL1, CXCR1 or CXCR2 expression and prognostic endpoints; however, univariate subgroup survival analysis demonstrated an inverse association between CXCL1 and recurrence-free survival (RFS) in stage III patients (P = 0.041). The CXCL8 positivity in the tumour infiltrate, however, correlated with earlier disease stage (P < 0.001) and improved relapse-free survival across the cohort (P < 0.001). Disease stage (P < 0.001) and tumour infiltrate CXCL8 positivity (P = 0.007) were associated with enhanced RFS in multivariate Cox regression analysis. CONCLUSION: Autocrine CXC-chemokine signalling may have adverse prognostic effects in early CRC. Conversely, CXCL8 positivity within the immune infiltrate may have good prognostic significance. British Journal of Cancer (2011) 104, 480-487. doi:10.1038/sj.bjc.6606055 www.bjcancer.com (C) 2011 Cancer Research UK
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