Article
Urology & Nephrology
Kendrick Yim, Chaoran Ma, Sigrid Carlsson, Hans Lilja, Lorelei Mucci, Kathryn Penney, Adam S. Kibel, Scott Eggener, Mark A. Preston
Summary: Adding percent free PSA to total PSA improved prediction of clinically significant prostate cancer and fatal prostate cancer. Free PSA can be used to stratify risk in screening and reduce unnecessary prostate biopsies.
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Sisse Helle Njor, Berit Andersen, Lennart Friis-Hansen, Niels de Haas, Dorte Linnemann, Henrik Norgaard, Ole Roikjaer, Bo Sondergaard, Morten Rasmussen
Summary: This study used a large number of cancer cases to estimate sensitivity and specificity for various cut-off values in CRC screening using FIT. The optimal cut-off value in an FIT population-based screening program is 45 ng Hb/ml when sensitivity and specificity are equally weighted. However, alternative optimal cut-off values of 125/80/175/350 ng Hb/ml are suggested if a lower number of colonoscopies are accepted to find one cancer.
Article
Medicine, General & Internal
Filippo Pesapane, Marzia Acquasanta, Rosario Di Meo, Giorgio Maria Agazzi, Priyan Tantrige, Marina Codari, Simone Schiaffino, Francesca Patella, Anastasia Esseridou, Francesco Sardanelli
Summary: Both unenhanced biparametric prostate MRI (bpMRI) and conventional multiparametric MRI (mpMRI) showed similar diagnostic performance in detecting prostate cancer, with no high-grade PCa missed by bpMRI.
Article
Public, Environmental & Occupational Health
Mette Bach Larsen, Mette Hedelund, Louisa Flander, Berit Andersen
Summary: This study aimed to test whether combining the standard invitation procedure with a pre-notification and/or an extra reminder can increase participation in colorectal cancer (CRC) screening. The results showed that the four-staged invitation procedure was the most effective, especially for the youngest age group.
PREVENTIVE MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonas Wallstrom, Kjell Geterud, Kimia Kohestani, Stephan E. Maier, Marianne Mansson, Carl-Gustaf Pihl, Andreas Socratous, Rebecka Arnsrud Godtman, Mikael Hellstrom, Jonas Hugosson
Summary: This study found that biparametric MRI was non-inferior to multiparametric MRI for cancer detection in prostate cancer screening, with fewer false positive results.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Jaegeun Lee, Seung Woo Yang, Long Jin, Chung Lyul Lee, Ji Yong Lee, Ju Hyun Shin, Jae Sung Lim, Ki Hak Song
Summary: The study suggests that PSAD and ETzD may be more sensitive and accurate than traditional PSA for patients with gray zone PSA levels undergoing prostate biopsy. Increasing the cut-off values of PSAD and ETzD helps reduce unnecessary prostate biopsies.
Article
Medicine, General & Internal
M. Luke Marinovich, Elizabeth Wylie, William Lotter, Helen Lund, Andrew Waddell, Carolyn Madeley, Gavin Pereira, Nehmat Houssami
Summary: In this study, the accuracy of artificial intelligence (AI) was compared with radiologists in breast cancer screening. The AI algorithm showed a lower AUC compared to radiologists. However, AI detected interval cancers that were missed by radiologists.
Article
Oncology
Aurore Carrot, Reza-Thierry Elaidi, Olivier Colomban, Denis Maillet, Michel Tod, Benoit You, Stephane Oudard
Summary: This study analyzed a phase III trial dataset in metastatic prostate cancer patients, demonstrating the significant prognostic value of modeled PSA kinetics parameters assessed using mathematical modeling. The results suggest that these parameters could serve as early prognostic/predictive factors in patients undergoing systemic treatments.
Article
Urology & Nephrology
Rilwan Babajide, Samuel Carbunaru, Oluwarotimi S. Nettey, Karriem S. Watson, Alfreda Holloway-Beth, Tiffany McDowell, Josef Ben Levi, Marcus Murray, James Stinson, Courtney M. P. Hollowell, Daniel P. Dalton, Le'Andre Moore, Rick A. Kittles, Peter H. Gann, Edward M. Schaeffer, Adam B. Murphy
Summary: The study validated the moderate accuracy of the Prostate Health Index in detecting Gleason grade group 2-5 prostate cancer in Black men. A cutoff of Prostate Health Index >= 28.0 can be safely used to avoid some unnecessary biopsies in this population.
JOURNAL OF UROLOGY
(2021)
Article
Management
Fengfeng Huang, Pengfei Guo, Yulan Wang
Summary: This study analyzes a group testing strategy that aims to maximize the efficiency of the SARS-CoV-2 screening test while maintaining its effectiveness. The study finds that group testing may result in a higher probability of false negative results but a lower probability of false positive results compared to individual testing. To ensure test effectiveness, the group size and disease prevalence need to be controlled within certain thresholds.
OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE
(2022)
Article
Oncology
Deborah A. Fisher, Leila Saoud, Kristen Hassmiller Lich, A. Mark Fendrick, A. Burak Ozbay, Bijan J. Borah, Michael Matney, Marcus Parton, Paul J. Limburg
Summary: The study found that assuming different adenoma sensitivities for screening and follow-up/surveillance colonoscopies can impact the potential benefits of stool-based screening strategies.
Article
Urology & Nephrology
Maria Franlund, Marianne Mansson, Rebecka Arnsrud Godtman, Gunnar Aus, Erik Holmberg, Karin Stinesen Kollberg, Par Lodding, Carl-Gustaf Pihl, Johan Stranne, Hans Lilja, Jonas Hugosson
Summary: This study analyzed the results of the Goteborg randomized prostate cancer screening trial over 22 years and found that prostate specific antigen-based screening can significantly reduce prostate cancer mortality. However, not attending screening, starting after age 60, and stopping at age 70 may increase the risk of prostate cancer death.
JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Alexander Light, Dost Jabarkhyl, Peter Gilling, Gincy George, Mieke Van Hemelrijck, Ben Challacombe, Sachin Malde, Rick Popert, Prokar Dasgupta, Oussama Elhage
Summary: A comparison of various surgical interventions for benign prostatic obstruction (BPO) showed that prostatic urethral lift (PUL) resulted in better erectile function scores at 24 months compared to monopolar transurethral resection (mTURP). However, there were no significant differences in erectile function following other interventions up to 60 months. Further randomized controlled trials comparing sexual function outcomes are recommended for future research.
Article
Surgery
Myrte Gorris, Nadine C. M. van Huijgevoort, Paul Fockens, Sybren L. L. Meijer, Joanne Verheij, Rogier P. P. Voermans, Roy L. J. van Wanrooij, Selma J. J. Lekkerkerker, Jeanin E. E. van Hooft
Summary: This study compared the sensitivity of two intraductal brush cytology devices for diagnosing malignant pancreatobiliary strictures and found that the dense brush was not superior to the conventional brush. The trial was prematurely ended due to futility.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Anssi Auvinen, Elisabeth Cardis, Maria Blettner, Monika Moissonnier, Siegal Sadetzki, Graham Giles, Christoffer Johansen, Anthony Swerdlow, Angus Cook, Sarah Fleming, Gabriele Berg-Beckhoff, Ivano Iavarone, Marie-Elise Parent, Alistair Woodward, Tore Tynes, Mary McBride, Dan Krewski, Maria Feyching, Toru Takebayashi, Bruce Armstrong, Martine Hours, Jack Siemiatycki, Susanna Lagorio, Signe Benzon Larsen, Minouk Schoemaker, Lars Klaeboe, Stefan Lonn, Joachim Schuz
Summary: Using data from the Interphone study, this research evaluated the effects of low-dose radiation from diagnostic radiological examinations on the risks of brain tumors. The results did not provide consistent evidence for increased risks of brain tumors from X-ray examinations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Urology & Nephrology
Antti Poyhonen, Jonne Akerla, Juha Koskimaki, Teuvo L. J. Tammela, Anssi Auvinen
Summary: Based on the population-based cohort study in Finland, sauna bathing was found to have no effect on the development or natural history of LUTS in the long-term.
SCANDINAVIAN JOURNAL OF UROLOGY
(2022)
Article
Oncology
Arla Vettenranta, Teemu J. Murtola, Jani Raitanen, Paavo Raittinen, Kirsi Talala, Kimmo Taari, Ulf-Hakan Stenman, Teuvo L. J. Tammela, Anssi Auvinen
Summary: Statin use affects the outcomes of PSA screening, with reduced incidence of advanced prostate cancer among statin users compared to nonusers, but similar detection rates for low-grade localized tumors.
Article
Oncology
Idris Olasunmbo Ola, Kirsi Talala, Teuvo Tammela, Kimmo Taari, Teemu Murtola, Paula Kujala, Jani Raitanen, Anssi Auvinen
Summary: PSA-based screening can reduce prostate cancer mortality, but may also lead to overdetection of low-risk disease. The incidence of prostate cancer is associated with PSA levels, with higher PSA values indicating an increased risk of aggressive disease. Risk stratification and appropriate rescreening intervals can help reduce overdetection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Lotta H. Nygard, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The use of antidiabetic medication, especially insulin, and untreated hyperglycemia are associated with an elevated risk of BPH surgery in diabetic men. These findings suggest that insulin use and high blood glucose levels may be risk factors for BPH.
Article
Public, Environmental & Occupational Health
Kaja Rahu, Mati Rahu, Hajo Zeeb, Anssi Auvinen, Evelyn Bromet, John D. D. Boice Jr
Summary: Mortality among Estonian cleanup workers in the Chernobyl area from 1986 to 2020 was studied. The all-cause standardized mortality ratio (SMR) was 1.04 and all-cancer mortality was elevated (SMR 1.16), with radiation-related cancers in excess (SMR 1.20). However, the excesses could be attributed to tobacco and alcohol consumption. Longer stays in the Chernobyl area, non-Estonian ethnicity, and lower education were associated with increased mortality risks. Suicide mortality was also increased, particularly among men with lower education.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biology
Olli Kurkela, Jaakko Nevalainen, Salla-Maaria Patsi, Katja Kojo, Olli Holmgren, Anssi Auvinen
Summary: This study estimated the number of lung cancer cases attributable to residential radon in Finland in 2017, considering factors such as age, sex, dwelling type, and smoking status. The results showed that at least 3% and at most 8% of all lung cancers were attributed to residential radon. Among smokers, the majority of radon-related cases were due to the joint effect of radon and smoking. Reducing radon exposure to specified action levels could significantly decrease the number of radon-attributable cases.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Public, Environmental & Occupational Health
Wafa Alimam, Atte Nikkila, Jani Raitanen, Kaija-Leena Kolho, Anssi Auvinen
Summary: The purpose of the study was to examine the association between residential mobility and childhood inflammatory bowel disease (IBD) risk. The findings suggest a slightly decreased risk of childhood IBD associated with residential mobility, especially when moving to rural areas and distances less than 50 km.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Urology & Nephrology
Sebastiaan Remmers, Chris H. Bangma, Rebecka A. Godtman, Sigrid. Carlsson, Anssi Auvinen, Teuvo L. J. Tammela, Louis J. Denis, Vera Nelen, Arnauld Villers, Xavier Rebillard, Maciej Kwiatkowski, Franz Recker, Stephen Wyler, Marco Zappa, Donella Puliti, Giuseppe Gorini, Alvaro Paez, Marcos Lujan, Daan Nieboer, Fritz H. Schroeder, Monique J. Roobol
Summary: Based on the guidelines of the European Association of Urology, a risk-based strategy for prostate cancer screening should be determined by the first prostate-specific antigen (PSA) level and age. In this study, the baseline PSA level was found to guide decisions on the repeat screening interval and had an impact on prostate cancer detection and specific mortality rates.
Article
Oncology
Kaja Rahu, Mati Rahu, Anssi Auvinen, Hajo Zeeb, John D. Boice Jr
Summary: From 1986 to 1991, 4831 men from Estonia were sent to clean up radioactively contaminated areas near Chernobyl. The study compared their cancer incidence rates to that of the male population of Estonia. It was found that there was an excess of radiation-related cancers combined, but not when smoking- and alcohol-related cancers were excluded. Less educated workers had a higher risk of all cancers and smoking-related cancers. An elevated risk of alcohol-related cancers was evident 15 to 24 years after return from the Chernobyl area.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Medicine, General & Internal
Anssi Auvinen
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Oncology
Julia Ventela, Anni Alanko, Anssi Auvinen, Olli Lohi, Atte Nikkila
Summary: This article conducted a systematic review to evaluate the association between childhood leukemia and autoimmune diseases. The study found a moderately increased risk of leukemia in children with autoimmune diseases. Further investigation is needed to explore the association for specific autoimmune diseases.
CANCER EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Anna-Maija Talvitie, Mika Helminen, Hanna Ojala, Teuvo Tammela, Anssi Auvinen, Ilkka Pietilae
Summary: Researchers found missing data issue in EPIC-26 scale, with 37% of patients leaving at least one question unanswered during follow-up. Factors associated with missingness include older age, lower education level, no relationship, more severe cancer, lower function scores in some EPIC domains, lower treatment satisfaction, or self-rated health. To improve validity, the hormonal section of the questionnaire needs additional explanation, and questions 8-10 should include a not-applicable option for sexually inactive patients.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Clinical Neurology
Tuomas Natukka, Joonas Haapasalo, Tomi Kivioja, Linnea Rajala, Jani Raitanen, Jaakko Nevalainen, Sirpa-Liisa Lahtela, Kristiina Nordfors, Minna Rauhala, Arja Jukkola, Juhana Frosen, Pauli Helen, Anssi Auvinen, Hannu Haapasalo
Summary: The study aimed to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas. The results showed that the time interval from referral to surgery within 4-10 weeks was not associated with decreased survivals in IDH-wt glioblastomas, while a delay exceeding 30 days from surgery to adjuvant treatment may decrease long-term survival.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Aino Siltari, Teemu J. Murtola, Josefina Kausz, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen
Summary: This study found that men using testosterone replacement therapy (TRT) were not at increased risk for prostate cancer (PCa) and did not experience increased mortality rate specifically from PCa or cardiovascular disease (CVD) compared to non-users. In fact, TRT users had a lower PCa mortality rate and slightly lower CVD and all-cause mortality.