期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 5, 页码 834-839出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604889
关键词
bladder cancer; urinary tract infection; bladder infection; Los Angeles; antibiotics
类别
资金
- US National Cancer Institute [P01 CA17054, R35 CA53890, R01 CA65726, R01 CA114665]
- US National Institute of Environmental Health Sciences [P01 ES05622, P30 ES07048]
- Galician Foundation of Genomic Medicine (CHUS, Galicia, Spain)
- Program of Instituto de Salud Carlos III (CHUVI, Galicia, Spain)
We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a population-based case-control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46-0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18-0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.
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