期刊
BRITISH JOURNAL OF CANCER
卷 99, 期 9, 页码 1506-1510出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604701
关键词
gender; neoplasm; oesophagus; cardia; population based
类别
资金
- National Cancer Institute (NCI) [R01 CA57947-03]
- wedish Cancer Society and Swedish Research Council
A nationwide Swedish case - control study of 388 men and 63 women with adenocarcinoma of the oesophagus and gastro-oesophageal function and 676 men controls and 140 women investigated whether sex differences in aetiology contribute to male predominance. Compared with men, women seemed more vulnerable to reflux (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 2.0 - 10.5 vs OR = 3.4, 95% CI = 2.5 - 4.6), obesity (OR = 10.3, 95% CI = 2.6 - 42.3 vs OR = 5.4, 95% CI = 2.6 - 10.8) and smoking (OR = 5.3, 95% CI = 2.0 - 14.1 vs OR = 2.8, 95% CI = 1.9 - 4.2), less harmed by low intake of fruit and vegetables (OR = 0.9, 95% CI = 0.3 - 2.4 vs OR = 1.6, 95% CI = 1.1 - 2.2) and less protected by Helicobacter pylori infection (OR = 0.5, 95% CI = 0.3 - 0.8 vs OR = 1.6, 95% CI = 0.5 - 5.4).
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