期刊
BRITISH JOURNAL OF CANCER
卷 98, 期 8, 页码 1431-1433出版社
SPRINGERNATURE
DOI: 10.1038/sj.bjc.6604258
关键词
P53; glioblastoma; methylation; mRNA
类别
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
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