Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Article
Multidisciplinary Sciences
Chen Zhou, Xiangman Zou, Xiaosha Wen, Zifen Guo
Summary: Our meta-analysis showed that the progesterone receptor gene Alu insertion and the V660L polymorphism contained in the PROGINS polymorphism were susceptibility factors for female reproductive cancer.
Article
Genetics & Heredity
Perizat Kanabekova, Amina M. Al-Awadi, Zhansaya Bauyrzhanova, Tania Tahtouh, Sameh Sarray, Wassim Y. Almawi
Summary: This study explored the association of genetic variations in the progesterone receptor (PGR) gene with ovarian cancer. It found that a specific variant, rs10895068, had a protective effect against ovarian cancer. The study also identified correlations between certain PGR variants and FIGO classification of ovarian cancer, as well as lymph node positivity. Haplotype analysis revealed negative associations between certain haplotypes and ovarian cancer risk.
Review
Endocrinology & Metabolism
Laura J. Mauro, Angela Spartz, Julia R. Austin, Carol A. Lange
Summary: Ovarian cancer is a rare but lethal gynecologic cancer with difficulties in early detection. Progesterone, previously believed to have a protective role, is now being challenged in its singular function. This article integrates historical perspectives, new research findings, and critical interpretations to provide a broader understanding of the role of progesterone and nPR signaling in ovarian cancer.
Article
Oncology
Rhonda-Lee F. Aoki, Stephen P. Uong, Scarlett Lin Gomez, Stacey E. Alexeeff, Bette J. Caan, Lawrence H. Kushi, Jacqueline M. Torres, Alice Guan, Alison J. Canchola, Brittany N. Morey, Katherine Lin, Candyce H. Kroenke
Summary: The study found that low neighborhood-level socioeconomic status is significantly associated with LumB and TNBC subtypes, while individual education is only associated with the Her2-e subtype, and individual income is not significantly associated with any breast cancer subtype.
Article
Pathology
Shiho Asaka, Ying Liu, Zheng-Cheng Yu, Yohan Suryo Rahmanto, Motoki Ono, Ryoichi Asaka, Tsutomu Miyamoto, Ting -Tai Yen, Ayse Ayhan, Tian -Li Wang, Ie-Ming Shih
Summary: Loss of ARID1A expression is associated with decreased PR expression in human and murine endometrial epithelial neoplasia, suggesting that ARID1A regulates PR transcription by modulating the PgR enhancer region during early tumor development.
Article
Oncology
Robert L. Hollis, Barbara Stanley, John P. Thomson, Michael Churchman, Ian Croy, Tzyvia Rye, Clare Bartos, Fiona Nussey, Melanie Mackean, Alison M. Meynert, Colin A. Semple, Charlie Gourley, C. Simon Herrington
Summary: Endometrioid ovarian carcinoma (EnOC) is a complex ovarian cancer type with distinct subtypes defined by hormone receptor expression and genomic features. Patients with high PR expression have better survival outcomes, while those with TP53 mutations in low PR tumors have a higher clinical need. Targeting MAPK and PI3K-AKT pathways, along with PARP inhibitors, may be effective therapeutic strategies for high-risk EnOC subtypes.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiahong Tan, Chunyan Song, Daoqi Wang, Yigang Hu, Dan Liu, Ding Ma, Qinglei Gao
Summary: High-grade serous ovarian cancer (HGSOC) with high expression of hormone receptors, including androgen receptor (AR), estrogen receptor alpha (ER), and progesterone receptor (PR), is associated with longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Correlation analysis shows significant positive correlations between hormone receptor expression and survival, indicating that AR, ER, and PR could serve as feasible prognostic biomarkers for HGSOC through immunohistochemical analysis. Co-expression of AR, ER, and PR has an improved predictive performance with an area under the curve (AUC) value of 0.945.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Cell Biology
John J. Peluso
Summary: This review discusses how PGRMC1 and PGRMC2 mediate signaling that influences ovarian follicle growth. The evidence shows that members of the PGRMC family promote follicle growth by regulating granulosa cell proliferation and viability.
Article
Endocrinology & Metabolism
Amani A. Mahbub, Akhmed Aslam, Mohamed E. Elzubier, Mohamed El-Boshy, Abdelghany H. Abdelghany, Jawwad Ahmad, Shakir Idris, Riyad Almaimani, Aiman Alsaegh, Mahmoud Zaki El-Readi, Mohammed A. Baghdadi, Bassem Refaat
Summary: The study found that the individual use of E2 and P4 can inhibit the development of colorectal cancer, showing good anti-tumor effects in male mice and cell experiments. The combination of the two shows a stronger anti-cancer effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Susann Badmann, Doris Mayr, Elisa Schmoeckel, Anna Hester, Christina Buschmann, Susanne Beyer, Thomas Kolben, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Summary: In this study, the authors investigated the role of AKR1C1/2, a target of the NRF2 pathway, in platinum-resistant epithelial ovarian cancer (EOC). They found that AKR1C1/2 is a key player in the development of chemoresistance and is associated with shorter progression-free survival. Inhibition of AKR1C1/2 and silencing of NRF2 enhanced the therapeutic effect of carboplatin and MPA in vitro. These findings suggest that combination therapy with carboplatin and MPA may be a promising approach for EOC patients.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Zhen Zheng, Xiao Li, Guoqiang Chen, Jing Chen, Xiaolu Zhu, Yincheng Teng
Summary: Perineural invasion (PNI) is found to be a significant independent prognostic factor in ovarian cancer (OC) patients, with shorter overall survival (OS) time. PNI positivity is negatively correlated with immune killer cell infiltration in OC tumor tissues. TAS2R proteins are upregulated in PNI-positive OC tissues and predict poor prognoses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Li Yang, Xin Chen, Xiang Qian, Jiejie Zhang, Meijuan Wu, Aijun Yu
Summary: In this study, transcriptome-wide m6A modifications of endometrioid ovarian cancer were investigated using high-throughput sequencing combined with methylated RNA immunoprecipitation. The m6A-modified genes were associated with tight junctions, cell adhesion molecules, and platinum drug resistance. Knockdown of METTL3 inhibited cell proliferation, promoted cell apoptosis, and induced cell cycle arrest at the G0/G1 phase in EOC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Alejandro La Greca, Nicolas Bellora, Francois Le Dily, Rodrigo Jara, Ana Silvina Nacht, Javier Quilez Oliete, Jose Luis Villanueva, Enrique Vidal, Gabriela Merino, Cristobal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo Vicent, Elmer Fernandez, Miguel Beato, Patricia Saragueta
Summary: Estrogen and progesterone play important roles in the development and transcriptional regulation of endometrial cancer. PAX2 is involved in fine-tuning the interplay between ERalpha and PR in transcriptional regulation, and the open chromatin state of specific regions is associated with regulated genes.
Article
Environmental Sciences
Ashley M. Geczik, Roni T. Falk, Xia Xu, Beatrice Wiafe-Addai, Joel Yarney, Baffour Awuah, Richard Biritwum, Verna Vanderpuye, Florence Dedey, Ernest Adjei, Francis Aitpillah, Ernest Osei-Bonsu, Joseph Oppong, Nicholas Titiloye, Lawrence Edusei, Kofi Nyarko, Joe-Nat Clegg-Lamptey, Seth Wiafe, Daniel Ansong, Thomas U. Ahearn, Jonine Figueroa, Montserrat Garcia-Closas, Louise A. Brinton, Britton Trabert
Summary: This study provides evidence that the use of lye-based hair relaxer products may increase circulating levels of 16-pathway estrogens, particularly estriol and 16-epiestriol. Additionally, scalp burns among hair relaxer users were associated with elevated levels of unconjugated estrogens. However, no association was found between the use of skin lighteners and estrogen metabolism.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Ophthalmology
Sabbir T. Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas English, David A. Mackey, Peter R. Ebeling, Bruce K. Armstrong, Donald S. A. McLeod, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Supplementing high-dose vitamin D may not significantly reduce the incidence of cataract surgery, regardless of age, sex, body mass index, serum vitamin D concentration, or ambient ultraviolet radiation.
Article
Oncology
Azam Majidi, Renhua Na, Susan J. Jordan, Anna DeFazio, Andreas Obermair, Michael Friedlander, Peter Grant, Penelope M. Webb
Summary: This study investigated the association between nonsteroidal antiinflammatory drug (NSAID) use and 5-year cancer-specific survival in Australian women with ovarian cancer. The results showed that frequent use of NSAIDs, including aspirin and nonaspirin NSAIDs, was associated with better survival compared to nonusers and infrequent users. These findings suggest that NSAID use might improve ovarian cancer survival.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Letter
Dermatology
Catherine M. Olsen, Nirmala Pandeya, David C. Whiteman
Summary: This study aimed to describe the incidence trends of invasive melanoma by histological subtype and thickness in two populations with different approaches to early detection (the US White population and Queensland, Australia). The incidence of thick melanoma (> 4.00 mm) increased at a faster rate than thinner melanomas in both populations over the period 1999-2018, primarily driven by nodular melanomas. Thin melanomas (< 1.00 mm) were predominantly of superficial spreading subtype, while thick melanomas (> 4.00 mm) were dominated by nodular melanomas.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Catherine M. Olsen, Louisa G. Gordon, Stacy M. Carter, David C. Whiteman
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
David M. Goldsbury, Amy Vassallo, Marianne Weber, Julia Steinberg, Penelope Webb, Anna DeFazio, Karen Canfell
Summary: This study aimed to estimate the direct health system costs of women diagnosed with ovarian cancer in Australia during 2006-2013, and found that the costs are substantial. Continued investment in ovarian cancer research, including prevention, early detection, and personalized treatments, is necessary to reduce the burden of the disease.
Article
Oncology
Hela Koka, Clara Bodelon, Steve Horvath, Priscilla Ming Yi Lee, Difei Wang, Lei Song, Tongwu Zhang, Amber Hurson, Jennifer Lyn Guida, Bin Zhu, Maeve Bailey-Whyte, Feng Wang, Cherry Wu, Koon Ho Tsang, Yee-Kei Tsoi, W. C. Chan, Sze Hong Law, Ray Ka Wai M. Hung, Gary Tse, Karen Ka-wan Yuen, Eric Karlins, Kristine Jones, Aurelie Vogt, Amy Hutchinson, Belynda Hicks, Montserrat Garcia-Closas, Stephen Chanock, Jill Barnholtz-Sloan, Lap Ah Tse, Xiaohong R. Yang
Summary: The study found that epigenetic age acceleration is associated with breast cancer subtypes and hormonal risk factors in breast tissue of Chinese patients, highlighting the interaction of hormonal, genomic, and epigenetic mechanisms in breast tissue aging.
CLINICAL EPIGENETICS
(2023)
Article
Oncology
Elle S. Kim, Robert B. Scharpf, Montserrat Garcia-Closas, Kala Visvanathan, Victor E. Velculescu, Nilanjan Chatterjee
Summary: Our study demonstrates the potential of combining age, polygenic risk scores (PRS), and non-genetic risk factors to stratify the risk and benefits of non-invasive multicancer early detection (MCED) liquid biopsy tests. We develop sex-specific pan-cancer risk scores (PCRSs) that incorporate body mass index, smoking, family history of cancers, and cancer-specific PRSs. These scores accurately predict the absolute risk of developing multiple common cancer types. We also show that PRSs improve the predictive performance of risk factors only models and provide positive and negative predictive values for promising multicancer screening tests based on age and PCRS-defined risk strata.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Taru Muranen, Anna Morra, Sofia R. Khan, Daniel K. Barnes, Manjeet Bolla, Joe Dennis, Renske Keeman, Goska T. Leslie, Michael Parsons, Qin U. Wang, Thomas Ahearn, Kristiina L. Aittomaeki, Irene K. Andrulis, Banu Arun, Sabine Behrens, Katarzyna E. Bialkowska, Stig J. Bojesen, Nicola Camp, Jenny Chang-Claude, Kamila Czene, Peter M. Devilee, Susan M. Domchek, Alison Dunning, Christoph Engel, D. Gareth Evans, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anne-Marie Gerdes, Gord Glendon, Pascal Guenel, Eric Hahnen, Ute Hamann, Helen J. Hanson, Maartje Hooning, Reiner Hoppe, Louise Izatt, Anna A. Jakubowska, Paul N. James, Vessela Kristensen, Fiona J. Lalloo, Geoffrey Lindeman, Arto Mannermaa, Sara L. Margolin, Susan G. Neuhausen, William Newman, Paolo Peterlongo, Kelly-Anne Phillips, Miquel Angel Pujana, Johanna Rantala, Karina Ronlund, Emmanouil K. Saloustros, Rita Schmutzler, Andreas F. Schneeweiss, Christian Singer, Maija Suvanto, Yen Yen R. Tan, Manuel Teixeira, Mads Thomassen, Marc Tischkowitz, Vishakha Tripathi, Barbara Wappenschmidt, Emily F. Zhao, Douglas C. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Paul D. P. K. Pharoah, Marjanka Schmidt, Carl Blomqvist, Heli Nevanlinna
Summary: This study assessed the PREDICT v 2.2 for prognosis of breast cancer patients with pathogenic germline BRCA1 and BRCA2 variants. The results showed that PREDICT had modest discrimination for BRCA1 carrier patients with ER-negative breast cancer, but clearly distinguished the high-mortality group from lower risk categories. However, for ER-positive breast cancer, the discrimination was slightly lower in BRCA2 variant carriers, and the inclusion of tumor grade distorted the prognostic estimates.
Article
Dermatology
Nirmala Pandeya, Jean Claude Dusingize, Catherine M. Olsen, Stuart Macgregor, Rachel E. Neale, Matthew H. Law, David C. Whiteman
Summary: Genetic risk is weakly associated with melanoma incidence and screening behavior, but it does not explain the higher rate of melanoma detection between screened and unscreened individuals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Catherine M. Olsen, Nirmala Pandeya, Bruna S. Ragaini, Rachel E. Neale, David C. Whiteman
Summary: We compared the incidence trends of cutaneous SCC (cSCC) and melanoma in populations residing at mid-to-high latitudes and found that the ratio of cSCC-to-melanoma incidence increased with proximity to the equator and over time, especially in women.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Simon Ezban Grutzmeier, Bojan Kovacevic, Peter Vilmann, Charlotte Vestrup Rift, Linea Cecilie Melchior, Morten Orebo Holmstrom, Lene Brink, Hazem Hassan, John Gasdal Karstensen, Hanne Grossjohann, Deepthi Chiranth, Anders Toxvaerd, Carsten Palnaes Hansen, Estrid Hogdall, Jane Preuss Hasselby, Pia Klausen
Summary: Pancreatic cancer is a devastating disease with a low survival rate. Patient-derived 3D cultures have shown promise for personalized treatment, but most models do not include supportive tissue cells. In this study, a co-culture model was created using cells from endoscopic biopsies, showing interaction between tumor and stromal cells. The study also highlights the need to include cancer-associated fibroblasts (CAFs) in models, as CAFs impact treatment response.
Article
Oncology
Pooja K. Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Javier Benitez, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, Emilie Cordina-Duverger, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugue, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G. Giles, Anna Gonzalez-Neira, Felix Grassmann, Anne Grundy, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Bernd Holleczek, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Christian Ingvar, Karolin Isaksson, Helena Jernstroem, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A. Murphy, William G. Newman, Sune F. Nielsen, Borge G. Nordestgaard, Aaron Norman, Katie M. O'Brien, Janet E. Olson, Alpa V. Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J. Ruddy, Dale P. Sandler, Christopher G. Scott, Mitul T. Shah, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Katarzyna Tomczyk, Melissa A. Troester, Therese Truong, Celine M. Vachon, Sophia S. Wang, Clarice R. Weinberg, Hans Wildiers, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong Yang, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Montserrat Garcia-Closas, Marjanka K. Schmidt, Peter Kraft, Roger L. Milne, Sara Lindstroem, Douglas F. Easton, Jenny Chang-Claude
Summary: A genome-wide study identified two independent SNP-risk factor pairs associated with breast cancer risk and estrogen receptor positive (ER +) breast cancer risk. Overall, gene-environment interactions have a very small contribution to the heritability of breast cancer. At the population level, these interactions do not significantly contribute to risk prediction for breast cancer.
BREAST CANCER RESEARCH
(2023)
Article
Mathematical & Computational Biology
Lorena Sandoval, Saleet Jafri, Jeya Balaji Balasubramanian, Praphulla Bhawsar, Jacob L. Edelson, Yasmmin Martins, Wolfgang Maass, Stephen J. Chanock, Montserrat Garcia-Closas, Jonas S. Almeida
Summary: The study developed a prototype personal risk score calculator to demonstrate how the PGS Catalog can be privately and readily applied to direct-to-consumer genetic testing services, such as 23andMe, without the need for software download, installation, or configuration.
BIOINFORMATICS ADVANCES
(2023)
