☆ 4.7 Article

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

BRITISH JOURNAL OF CANCER (2008)

期刊

BRITISH JOURNAL OF CANCER

卷 98, 期 11, 页码 1820-1823

出版社

NATURE PUBLISHING GROUP

DOI: 10.1038/sj.bjc.6604380

关键词

metalloproteinase; SNP; survival; prognosis

类别

Oncology

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摘要

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.

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