Review
Chemistry, Analytical
Yi -Tong Xu, Yi -Fan Ruan, Tian-Yang Zhang, Xiao-Mei Shi, Hai-Yan Wang, Wei -Wei Zhao, Hong -Yuan Chen, Jing -Juan Xu
Summary: Single-cell analysis is a challenging yet important task in cell biology, and various techniques have been developed for this purpose. Nanopipette-based ion current rectification electroanalysis has emerged as a promising method in this field. This review discusses the working principle of this method, its key regulation factors, and presents illustrative examples of sensing strategies for single-cell analysis. Future perspectives in this area are also proposed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wenhao Ma, Wanyi Xie, Rong Tian, Xiaoqing Zeng, Liyuan Liang, Changjun Hou, Danqun Huo, Deqiang Wang
Summary: Since the outbreak of COVID-19, rapid and effective detection methods have been a focus of research. This study utilized aptamer-functionalized nanopipettes with unique ion current rectification properties to achieve rapid and highly sensitive detection of trace viral protein, reducing the cost of detection. The sensor platform exhibited a wide dynamic working range and a low detection limit, showing great potential as a tool for rapid detection of SARS-CoV-2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Yue Wang, Rujia Liu, Xiaoyue Shen, Dengchao Wang
Summary: This study investigates the effects of multivalent ions on electron transfer processes in carbon nanopipettes using both experimental and simulation methods. The results show that multivalent cations can adsorb on the negatively charged carbon surface and attract more ions into the cavity, resulting in increased current response.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Yuhuan Wang, Rujia Liu, Yingfei Ma, Xiaoyue Shen, Dengchao Wang
Summary: This study developed a series of metal-decorated carbon nanopipettes for advanced electrochemical sensing applications in small spaces. The nanopipettes, decorated with Au, Ag, and Pt on the inner walls, demonstrated good sensing performances for various important analytes. This simple and effective approach can be further expanded for more versatile and powerful measurements in electrochemical sensing and imaging applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Nako Nakatsuka, Alix Failletaz, Dominic Eggemann, Csaba Forro, Janos Voros, Dmitry Momotenko
Summary: Artificial quartz nanopipettes functionalized with aptamers are able to reversibly recognize serotonin with high specificity and can detect physiologically relevant amounts of serotonin in complex environments. By utilizing complementary techniques such as quartz crystal microbalance and electrochemical impedance spectroscopy, the detection mechanism and theoretical model for aptamer-modified nanopipettes are investigated, demonstrating their potential as versatile tools for biological systems.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Rujia Liu, Yingfei Ma, Xiaoyue Shen, Dengchao Wang
Summary: Conductive nanopipettes have been used as multifunctional probes for electrochemical and ion transport measurements. The study found that the current signals in carbon nanopipettes are determined by electron transfer or ion transport under different conditions. The quantified charge transport processes inside CNPs will help optimize their usage in single-entity sensing and imaging applications.
Article
Chemistry, Analytical
Rujia Liu, Rui Jia, Dengchao Wang, Michael V. Mirkin
Summary: Recently, conductive carbon nanopipettes have been used for electrochemical resistive-pulse (ERP) sensing to detect single liposomes and biological vesicles, and analyze the redox molecules contained in them. However, the origins of different shapes of current transients produced by the translocation of single vesicles through the nanopipette remain unclear. This study extensively simulated the current blockage by vesicles approaching and passing through the pipet orifice, as well as the faradaic current spike caused by the oxidation/reduction of redox species released from vesicles on the carbon surface, investigating the effects of various parameters on the shape of current transients.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ian J. McPherson, Peter Brown, Gabriel N. Meloni, Patrick R. Unwin
Summary: Nanopipettes are increasingly used as nano test tubes with reactions triggered by electrochemical potential, but a study demonstrated that dye ingress from the bath into the nanopipette was not observed under large applied tip potentials. Finite element method simulations showed that this is due to the dominance of electro-osmosis in mass transport. The results highlight significant deviations in mass transport behavior at the nanoscale and the utility of the combined LSCM and FEM approach in deepening understanding.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yi-Li Liu, Si-Yuan Yu, Jia-Hao Chen, Cheng-Shuang Wang, Heng-Ye Li, Dechen Jiang, Deju Ye, Wei-Wei Zhao
Summary: Single-cell interrogation using solid-state nanoprobes allows for understanding the connection between cellular behavior and heterogeneity. A generic ionic current rectification (ICR) single-cell methodology is developed based on the charge property of the organic molecular probe (OMP), enabling subcellular detection of glutathione (GSH) with high selectivity, sensitivity, and recyclability.
Article
Chemistry, Multidisciplinary
Amalia Rizki Fauziah, Li-Hsien Yeh
Summary: A novel heterogenous subnanochannel membrane with a tri-continuous pore structure has been reported, which exhibits enhanced ion selectivity, strong ion current rectification, and ultrafast ion transport properties in organic electrolyte solutions. By mixing solutions of different salinity, a high power output can be achieved, paving the way for efficient ion separation and high-performance energy harvesters.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xiao-Yuan Wang, Jian Lv, Xue Wu, Qin Hong, Ruo-Can Qian
Summary: Nanopipette, fabricated by glasses with a nanoscale pore in the tip, has been proven to be immensely useful in electrochemical analysis. There are numerous nanopipette-based sensors with improved sensitivity, selectivity, ease of use, and miniaturization. This minireview provides an overview of recent developments in nanopipette-based electrochemical sensors, including different types of nanopipettes and their modification materials for functionalization.
Article
Materials Science, Multidisciplinary
Yaning Li, Yuxia Gao
Summary: Recently, enhanced ionic current rectification induced by the concentration gradient has been reported, particularly in graphene nanochannels. However, the reasons for this enhancement in graphene conical nanochannels are unclear. In this study, a finite element model of a single graphene conical nanochannel was established to investigate the fundamental mechanisms. The model showed that the cation concentration caused by graphene was 42 times higher than the bulk ion concentration. The enhancement of ionic current rectification was attributed to the unique structure of the graphene nanochannel and the graphene membrane with a high surface charge density.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jianze Feng, Yan Wang, Yongtai Xu, Hongyun Ma, Gaowei Wang, Pengjun Ma, Yu Tang, Xingbin Yan
Summary: This study introduces a novel bias-direction-adjustable supercapacitor-diode with high rectification ratio and outstanding cycling life, representing a significant breakthrough in designing high-performance capacitive ionic diodes.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Liu Shi, Deqi Kuang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Jie Yang, Genxi Li
Summary: Bioinspired nanochannels are a powerful tool in bioengineering and biomedical research. They have robust mechanical and controllable chemical properties. By introducing charged peptide assembly, ion current rectification can be modulated, leading to the construction of an ionic sensory platform for peptide-associated biotarget assay.
Article
Nanoscience & Nanotechnology
Juan Mitchell, Chris Pintro, Katie Nolan, Maurice Davenport-Munoz, Kyle Spitzer, Rachel Yu, Ji Wu
Summary: This study demonstrates the construction of a simple and efficient ionic current rectification (ICR) platform using nanoparticles and a nanoporous membrane. The efficiency of the ICR system can be enhanced by using smaller pore size, lower ionic strength, appropriate pH value, higher electrical field strength, and lower density of nanoparticles. The principles of this new ICR system have potential applications in controllable drug delivery, energy storage, and water purification.
Article
Optics
Fanglong Yuan, Ya-Kun Wang, Geetu Sharma, Yitong Dong, Xiaopeng Zheng, Peicheng Li, Andrew Johnston, Golam Bappi, James Z. Fan, Hao Kung, Bin Chen, Makhsud I. Saidaminov, Kamalpreet Singh, Oleksandr Voznyy, Osman M. Bakr, Zheng-Hong Lu, Edward H. Sargent
Article
Multidisciplinary Sciences
Yi Hou, Erkan Aydin, Michele De Bastiani, Chuanxiao Xiao, Furkan H. Isikgor, Ding-Jiang Xue, Bin Chen, Hao Chen, Behzad Bahrami, Ashraful H. Chowdhury, Andrew Johnston, Se-Woong Baek, Ziru Huang, Mingyang Wei, Yitong Dong, Joel Troughton, Rawan Jalmood, Alessandro J. Mirabelli, Thomas G. Allen, Emmanuel Van Kerschaver, Makhsud I. Saidaminov, Derya Baran, Qiquan Qiao, Kai Zhu, Stefaan De Wolf, Edward H. Sargent
Article
Chemistry, Multidisciplinary
Dongxin Ma, Petar Todorovic, Shadi Meshkat, Makhsud Saidaminov, Ya-Kun Wang, Bin Chen, Peicheng Li, Benjamin Scheffel, Rafael Quintero-Bermudez, James Z. Fan, Yitong Dong, Bin Sun, Chao Xu, Chun Zhou, Yi Hou, Xiyan Li, Yuetong Kang, Oleksandr Voznyy, Zheng-Hong Lu, Dayan Ban, Edward H. Sargent
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Bin Sun, Maral Vafaie, Larissa Levina, Mingyang Wei, Yitong Dong, Yajun Gao, Hao Ting Kung, Margherita Biondi, Andrew H. Proppe, Bin Chen, Min-Jae Choi, Laxmi Kishore Sagar, Oleksandr Voznyy, Shana O. Kelley, Frederic Laquai, Zheng-Hong Lu, Sjoerd Hoogland, F. Pelayo Garcia de Arguer, Edward H. Sargent
Article
Multidisciplinary Sciences
Ding-Jiang Xue, Yi Hou, Shun-Chang Liu, Mingyang Wei, Bin Chen, Ziru Huang, Zongbao Li, Bin Sun, Andrew H. Proppe, Yitong Dong, Makhsud I. Saidaminov, Shana O. Kelley, Jin-Song Hu, Edward H. Sargent
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Ya-Kun Wang, Dongxin Ma, Fanglong Yuan, Kamalpreet Singh, Joao M. Pina, Andrew Johnston, Yitong Dong, Chun Zhou, Bin Chen, Bin Sun, Hinako Ebe, James Fan, Meng-Jia Sun, Yuan Gao, Zheng-Hong Lu, Oleksandr Voznyy, Liang-Sheng Liao, Edward H. Sargent
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Bin Sun, Andrew Johnston, Chao Xu, Mingyang Wei, Ziru Huang, Zhang Jiang, Hua Zhou, Yajun Gao, Yitong Dong, Olivier Ouellette, Xiaopeng Zheng, Jiakai Liu, Min-Jae Choi, Yuan Gao, Se-Woong Baek, Frederic Laquai, Osman M. Bakr, Dayan Ban, Oleksandr Voznyy, F. Pelayo Garcia de Arquer, Edward H. Sargent
Article
Chemistry, Multidisciplinary
Joao M. Pina, Darshan H. Parmar, Golam Bappi, Chun Zhou, Hitarth Choubisa, Maral Vafaie, Amin M. Najarian, Koen Bertens, Laxmi Kishore Sagar, Yitong Dong, Yuan Gao, Sjoerd Hoogland, Makhsud Saidaminov, Edward H. Sargent
Summary: A method utilizing a vapor-assisted chlorination strategy to synthesize low-dimensional CsPbCl3 thin films exhibiting deep-blue emission is reported, achieving high-quality perovskite thin films with low surface roughness and efficient charge transfer properties. This enables the fabrication of vertical-cavity surface-emitting lasers with low lasing thresholds and showcases the prospect of increasing the range of deep-blue laser sources.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Mingzhi Li, Peng He, Zhengyou Yu, Shudong Zhang, Chaoyue Gu, Xin Nie, Yaxiong Gu, Xianhao Zhang, Zhiwei Zhu, Yuanhua Shao
Summary: The study focuses on the trans-interfacial behaviors of multiple ionic species at the interface between two immiscible electrolyte solutions, demonstrating the effectiveness of utilizing host-guest interaction to facilitate ion transfer. The facilitated ion transfer process of dendrimers at the microinterfaces is investigated, revealing selective coordination between dendrimers and ligands. The mechanism of the FIT process is proposed, suggesting a deprotonation process at the interface for higher-generation dendrimers.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ya-Kun Wang, Fanglong Yuan, Yitong Dong, Jiao-Yang Li, Andrew Johnston, Bin Chen, Makhsud I. Saidaminov, Chun Zhou, Xiaopeng Zheng, Yi Hou, Koen Bertens, Hinako Ebe, Dongxin Ma, Zhengtao Deng, Shuai Yuan, Rui Chen, Laxmi Kishore Sagar, Jiakai Liu, James Fan, Peicheng Li, Xiyan Li, Yuan Gao, Man-Keung Fung, Zheng-Hong Lu, Osman M. Bakr, Liang-Sheng Liao, Edward H. Sargent
Summary: The all-inorganic nature of CsPbI3 perovskites enhances stability in perovskite devices. Inorganic ligand exchange leads to CsPbI3 QD films with superior phase stability and increased thermal transport. LEDs with KI-exchanged QD films exhibit increased thermal transport and higher operating stability compared to control devices.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Yitong Dong, Tong Zhu, Dongxin Ma, Andrew Proppe, Bin Chen, Chao Zheng, Yi Hou, Seungjin Lee, Bin Sun, Eui Hyuk Jung, Fanglong Yuan, Ya-kun Wang, Laxmi Kishore Sagar, Sjoerd Hoogland, F. Pelayo Garcia de Arquer, Min-Jae Choi, Kamalpreet Singh, Shana O. Kelley, Oleksandr Voznyy, Zheng-Hong Lu, Edward H. Sargent
Summary: This study introduces a new type of perovskite quantum dots that remain stable in a thin layer of precursor solution and utilize strained QDs as nucleation centers to drive homogeneous crystallization. These new materials show suppressed Auger bi-exciton recombination and bright luminescence under high excitation, leading to primary red LEDs with significantly enhanced performance compared to control materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Dongxin Ma, Kebin Lin, Yitong Dong, Hitarth Choubisa, Andrew H. Proppe, Dan Wu, Ya-Kun Wang, Bin Chen, Peicheng Li, James Z. Fan, Fanglong Yuan, Andrew Johnston, Yuan Liu, Yuetong Kang, Zheng-Hong Lu, Zhanhua Wei, Edward H. Sargent
Summary: By using a fluorinated triphenylphosphine oxide additive to control cation diffusion and passivate surfaces, the efficiency and operating lifetimes of perovskite light-emitting diodes have been improved. Although reduced-dimensional perovskites show promise in increasing stability and photoluminescence quantum yield, challenges such as lower EQEs and inferior color purities remain.
Article
Electrochemistry
Junjie Liu, Xinhe Zheng, Yutong Hua, Jintao Deng, Peng He, Zhengyou Yu, Xianhao Zhang, Xiaohong Shi, Yuanhua Shao
Summary: Suitable organic solvents play a crucial role in electrochemical studies at liquid/liquid (L/L) interfaces. This study measured the thermodynamic and kinetic parameters of simple ion transfer at the water/trifluorotoluene (W/TFT) interface using micro- and nanopipettes voltammetry. The research also explored ions with transfer potentials close to the potential window ends and developed two novel L/L interfaces for studying various ion transfer reactions. Compared to traditional organic solvents, the W/TFT and its derivatives interfaces showed lower toxicity, better stability, and wider potential windows, making them preferable choices in electrochemical studies at L/L interfaces.
Article
Chemistry, Multidisciplinary
Xianhao Zhang, Qi-Fa Chen, Jintao Deng, Xinyu Xu, Jirui Zhan, Hao-Yi Du, Zhengyou Yu, Meixian Li, Ming-Tian Zhang, Yuanhua Shao
Summary: This study directly observed and identified key intermediates during the water oxidation catalyzed by a cobalt-tetraamido macrocyclic ligand complex using a newly developed in situ electrochemical mass spectrometry method, which further confirmed the rationality of the mechanism.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Seungjin Lee, Laxmi Kishore Sagar, Xiyan Li, Yitong Dong, Bin Chen, Yuan Gao, Dongxin Ma, Larissa Levina, Aidan Grenville, Sjoerd Hoogland, F. Pelayo Garcia de Arguer, Edward H. Sargent
CHEMISTRY OF MATERIALS
(2020)
