Review
Physiology
Mengru Xu, Huaiwu He, Yun Long
Summary: EIT technology offers promise in bedside visual assessment of lung perfusion distribution, with attention being focused on the saline bolus EIT method. Experimental and clinical studies have demonstrated good consistency between saline bolus EIT and SPECT in evaluating lung perfusion changes in various pathological conditions. Further research is needed to establish consensus on the clinical application and impact of the saline bolus EIT method.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anne Sibille, Jean-Louis Corhay, Renaud Louis, Vincent Ninane, Guy Jerusalem, Bernard Duysinx
Summary: This review examines the biological properties of eosinophils in non-small cell lung cancer (NSCLC) and their roles in both tumor promotion and inhibition. The potential value of eosinophils as prognostic and predictive biomarkers is discussed, along with the need for stronger clinical data. Perspectives on clinical and translational research topics in this area are also provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Mireia Mor Conejo, Carmina Guitart Pardellans, Elena Fresan Ruiz, Daniel Penela Sanchez, Francisco Jose Cambra Lasaosa, Iolanda Jordan Garcia, Monica Balaguer Gargallo, Marti Pons-Odena
Summary: This study evaluates the use of bedside lung ultrasound for assessing PEEP-induced pulmonary reaeration during recruitment maneuvers in pediatric patients with acute respiratory distress syndrome (ARDS). The findings suggest that lung ultrasound can be used in real-time to monitor and assess lung recruitment, providing valuable information on the effectiveness of the maneuvers and the risk of lung overdistension.
Article
Acoustics
Marry R. Smit, Luigi Pisani, Eva J. E. de Bock, Erdinand van der Heijden, F. Paulus, Ludo F. M. Beenen, Stije J. Leopold, Michaela A. M. Huson, P. C. Henwood, E. D. Riviello, A. P. Walden, A. M. Dondorp, M. J. Schultz, Lieuwe D. J. Bos
Summary: This study evaluated the influence of penetration depth of lung ultrasound (LUS) on the accuracy of LUS findings in ICU patients. The results suggest that the LUS aeration score and B-line percentage score accurately reflect lung aeration, but interpretation should consider the subpleural penetration depth of ultrasound.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Pediatrics
Xiaolei Liu, Shuyu Si, Yiyi Guo, Hui Wu
Summary: Lung ultrasound is a low-cost, radiation-free, and easy-to-operate tool that has high sensitivity and specificity in diagnosing neonatal respiratory distress syndrome, transient tachypnoea of newborns, and pneumothorax. However, it has limitations in some other lung diseases due to reflection artifacts.
FRONTIERS IN PEDIATRICS
(2022)
Article
Acoustics
Jui Fang, Yen-Nien Ting, Yi-Wen Chen
Summary: This study explored the feasibility of using ShanEn estimated through grayscale histogram analysis of LUS images for quantifying pulmonary aeration. The linear correlation between ShanEn and weight ratio improved with higher gain and dynamic range. High gain and dynamic range are crucial for accurate assessment of pulmonary aeration using ShanEn.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Engineering, Environmental
Federico Pasini, Manel Garrido-Baserba, Ahmed Ahmed, George Nakhla, Domenico Santoro, Diego Rosso
Summary: Primary screening can significantly improve oxygen transfer efficiency, with improvements of 27% at pilot scale and 20% at full scale. By integrating changes in oxygen transfer efficiency and carbon redirection, the impact of primary screening on facility energy balance can be explored. Through wide-plant assessment of different scenarios, primary screening can improve energy balance up to 15%, providing insight into the advantages and limitations of energetic sustainability.
WATER ENVIRONMENT RESEARCH
(2021)
Article
Mechanics
Zhipeng Ren, Deyou Li, Xiaolong Fu, Hongjie Wang, Jintao Liu, Yong Li
Summary: Through numerical calculations, it was found that complex gas-liquid behaviors, including liquid absorption and evaporation, gas absorption and condensation, and gas-liquid distribution, occur in gas-liquid mixture transport systems. The synergetic effects of gaseous and vapor cavitations lead to an increase in mass-transfer rate and hydrodynamic instability. In the impeller, the absorption-dominated region is located in the suction surfaces of the long blade, while the evolved-dominated mass-transfer bands exist along the edge of the vapor cavity. The increase in gas volume fraction exacerbates the instability of the impeller forces.
Article
Critical Care Medicine
Congli Zeng, Min Zhu, Gabriel Motta-Ribeiro, David Lagier, Takuga Hinoshita, Mingyang Zang, Kira Grogg, Tilo Winkler, Marcos F. Vidal Melo
Summary: Maximizing compliance with the highest positive end-expiratory pressure (PEEP) strategy can improve lung aeration and reduce ventilator-induced lung injury in an acute respiratory distress syndrome (ARDS) model. This strategy improves lung ventilation homogeneity and decreases lung injury.
Article
Biotechnology & Applied Microbiology
Oskar Rosmark, Arturo Ibanez-Fonseca, Johan Thorsson, Goran Dellgren, Oskar Hallgren, Anna-Karin Larsson Callerfelt, Linda Elowsson, Gunilla Westergren-Thorsson
Summary: This study introduces a novel in vitro culture methodology that combines cyclic stretch with 3D cell culture platforms for better understanding of cell behavior. The researchers developed a device that mimics the breathing human lung and validated its effectiveness by culturing lung epithelial cells. The results showed that cyclic stretch increased the expression of the SFTPB gene, while the ECM environment lowered the expression of basement membrane protein genes. The device also showed good compatibility with rat lung tissue slices.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Jiang, Jing Liu, Jingang Cui, Jilei Su, Wei Xu, Fang Zhang, Yongsheng Ding
Summary: This study investigated the cell death induced by mechanical ventilation and found that ferroptosis may be an alternative pathway for ventilator-induced lung damage (VILI). The results also suggested a connection between the ventilation-induced death of lung cells and iron regulation and glutathione metabolism. Further experiments on animal models and clinical data are needed to confirm these findings.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Huihui Li, Zexin Chen, Ning Chen, Yun Fan, Yaping Xu, Xiaoling Xu
Summary: Lung cancer, as the leading cause of cancer-related mortality, remains a global threat to human health. Despite progress in research and treatment, there is an urgent need for reliable preclinical models and therapeutic approaches. Patient-derived organoids have emerged as a promising model for high-throughput drug screening and guidance for lung cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Nanoscience & Nanotechnology
Kun Man, Jiafeng Liu, Cindy Liang, Christopher Corona, Michael D. Story, Brian Meckes, Yong Yang
Summary: Determining the mechanistic causes of lung diseases and developing new treatments would benefit from a clinically relevant preclinical human lung alveolar interstitium model. Existing models fail to replicate the key physiological characteristics of human alveoli. A human lung alveolar interstitium chip was developed to imitate the microenvironmental factors of alveoli and showed improved epithelial barrier function compared to transwell models. The chip sustained interstitial integrity and enhanced the epithelial barrier, resulting in a longevity that extended beyond eight weeks. The chip also provided accurate assessment of multiwalled carbon nanotube toxicity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pediatrics
Emily J. Pryor, Douglas A. Blank, Stuart B. Hooper, Kelly J. Crossley, Shiraz Badurdeen, James A. Pollock, Andrew V. Stainsby, Linda C. P. Croton, Dylan W. O'Connell, Christopher J. Hall, Anton Maksimenko, Daniel Hausermann, Peter G. Davis, Marcus J. Kitchen
Summary: The study demonstrated a strong correlation between LUS image analysis techniques and air volumes measured by CT scans. LUS was found to accurately provide relative measures of lung aeration after birth in neonatal lambs. Future studies are needed to assess if LUS can be used to evaluate air volumes and personalize aeration strategies for critically ill newborns in real time.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Mike Shaughness, Kimberly Byrnes
Summary: The study demonstrates significant alterations in microglial function following stretch-injury, indicating a potential impact on their response to injury or interaction with other cells.
MOLECULAR NEUROBIOLOGY
(2021)
