Article
Medicine, Research & Experimental
Ting Sun, Yunliang Sun, Xiao Huang, Jianghua Liu, Jiabin Yang, Kai Zhang, Guiqing Kong, Fang Han, Dong Hao, Xiaozhi Wang
Summary: REM sleep, melatonin, and cortisol levels are significantly associated with the risk of ICU-acquired delirium. Reduced REM sleep, lower melatonin levels, and higher cortisol levels can predict the occurrence of delirium.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Erin Eschbach, Jing Wang
Summary: Critical illness and stays in the ICU have a significant impact on sleep, with poor sleep being common in this setting. Recent clinical practice guidelines have focused more on sleep and circadian disruption in the ICU, leading to new initiatives in studying and improving sleep complications in critically ill patients. The COVID-19 pandemic has also heightened levels of sleep disruption, with ongoing developments in understanding this issue.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Peter S. Cunningham, Gareth B. Kitchen, Callum Jackson, Stavros Papachristos, Thomas Springthorpe, David van Dellen, Julie Gibbs, Timothy W. Felton, Anthony J. Wilson, Jonathan Bannard-Smith, Martin K. Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur E. Akman, Andrew L. Hazel, John F. Blaikley
Summary: Researchers proposed a method called ClinCirc to measure circadian rhythms in hospitalized patients, which is challenging due to infrequent sampling. Through comparisons with simulated and frequently sampled biological data, ClinCirc showed high accuracy and revealed important clinical associations in the ICU patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Eva Hennecke, Denise Lange, Florian Steenbergen, Judith Fronczek-Poncelet, David Elmenhorst, Andreas Bauer, Daniel Aeschbach, Eva-Maria Elmenhorst
Summary: Chronic sleep deficits can impair spatial working memory and worsen its performance during acute sleep loss, although verbal working memory and declarative memory are not affected by restricted sleep.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ting Gao, Zixu Wang, Yulan Dong, Jing Cao, Yaoxing Chen
Summary: Melatonin can prevent sleep deprivation-induced colitis by regulating gut microbiota and metabolite composition, while butyrate also plays a crucial role in disease occurrence. However, melatonin may be a more effective therapy for colitis, possibly involving the up-regulation of Faecalibacterium and butyrate levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Stuti J. Jaiswal, Dae Y. Kang, Nathan E. Wineinger, Robert L. Owens
Summary: The study found that delirium patients had significantly increased sleep fragmentation, shorter total sleep duration, more short sleep bouts, and fewer longer sleep bouts. This suggests that sleep fragmentation may be useful in predicting delirium.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Michelle E. Stepan, Erik M. Altmann, Kimberly M. Fenn
Summary: Short naps may not mitigate the effects of sleep deprivation on cognitive processing, longer naps may be necessary. However, in participants who took naps, more time spent in slow-wave sleep was associated with reduced performance deficits.
Article
Critical Care Medicine
Christopher G. Hughes, Christina S. Boncyk, Benjamin Fedeles, Pratik P. Pandharipande, Wencong Chen, Mayur B. Patel, Nathan E. Brummel, James C. Jackson, Rameela Raman, E. Wesley Ely, Timothy D. Girard
Summary: Cholinesterase activity during critical illness is associated with delirium but not with outcomes after discharge.
Article
Clinical Neurology
Michelle E. Stepan, Erik M. Altmann, Kimberly M. Fenn
Summary: Studies on the impact of brief naps on cognitive processing found that longer nap times may be necessary to mitigate impairments caused by sleep deprivation, but spending more time in slow-wave sleep was associated with improved memory consolidation in participants who napped.
Review
Clinical Neurology
Siaw Cheok Liew, Thidar Aung
Summary: Sleep deprivation is a significant public health concern, and many studies have explored the association between sleep deprivation and health risks. However, comprehensive updates and reviews in this aspect remain scarce. This study aims to provide insight into the relationship between sleep deprivation and disease development, identifying possible causal relationships and mechanisms for future research.
Article
Hematology
Xiao Li, Ying Cao, Xinxin Xu, Chongyue Wang, Qingbin Ni, Xiang Lv, Chao Yang, Zhaoqiang Zhang, Xufeng Qi, Guohua Song
Summary: Insufficient or disrupted sleep increases the risk of cardiovascular disease, such as atherosclerosis. This study investigates the potential role of circulating exosomes in endothelial inflammation and atherogenesis under sleep deprivation and the molecular mechanisms involved. The findings suggest that sleep deprivation induces endothelial inflammation and atherogenesis through exosomes, particularly miR-182-5p, which upregulates MYD88 and activates the NF-kappa B/NLRP3 pathway. This study provides insights into the link between sleep disorder and cardiovascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenhua Li, Yinlong Cheng, Yi Zhang, Yazhi Qian, Mo Wu, Wei Huang, Nan Yang, Yanyong Liu
Summary: Healthy sleep is crucial for maintaining the body's balance, but sleep disorders have become a major global health problem. Shumian capsule, a traditional Chinese medicine used for insomnia, has been found to have antidepressant and sedative effects, with melatonin receptors playing a key role. In experiments with sleep-deprived mice, Shumian capsule significantly alleviated insomnia symptoms and improved related mental disorders. The study also compared it to ramelteon, a selective melatonin receptor agonist, which only improved sleep latency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Joaquin U. Gonzales, Jacob R. Dellinger, Cayla Clark
Summary: The aim of this study was to investigate the association between sleep duration and brain activation, as well as the role of chronotype. The results showed that both sleep duration and chronotype were significantly correlated with prefrontal cerebral oxygenation during a working memory task. Adjusting for chronotype weakened the relationship between sleep duration and cerebral oxygenation, while adjusting for sleep duration did not affect the relationship between chronotype and cerebral oxygenation. Sleep extension did not significantly impact cerebral oxygenation. Participants with earlier chronotypes exhibited greater cerebral oxygenation responses, even after sleep extension.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Reine Ibala, Jennifer Mekonnen, Jacob Gitlin, Eunice Y. Hahm, Breanna R. Ethridge, Katia M. Colon, Sophia Marota, Cristy Ortega, Juan C. Pedemonte, Marisa Cobanaj, Shubham Chamadia, Jason Qu, Lei Gao, Riccardo Barbieri, Oluwaseun Akeju
Summary: In hospitalized older patients undergoing elective major cardiac surgery, longer sleep duration is associated with postoperative delirium.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Cindy Stroemel-Scheder, Stefan Lautenbacher
Summary: This study aimed to develop and validate an experimental protocol for assessing at-home recovery sleep after sleep deprivation. The results indicate successful implementation of the protocol, suggesting it as a useful tool for future studies on recovery sleep outside of well-equipped sleep laboratories.
Letter
Critical Care Medicine
Jennifer D. Paratz, Jeffrey Lipman, Robert J. Boots
CRITICAL CARE MEDICINE
(2015)
Article
Critical Care Medicine
Geetha Kayambu, Robert Boots, Jennifer Paratz
INTENSIVE CARE MEDICINE
(2015)
Article
Neurosciences
Judith Bellapart, Catherine Abi-Fares, Kylie Cuthbertson, Kimble Dunster, Sara Diab, David G. Platts, Christopher Raffell, Levon Gabrielian, Adrian Barnett, Jennifer Paratz, Rob Boots, John F. Fraser
Article
Medical Laboratory Technology
Judith Bellapart, Jason Alexander Roberts, Vinesh Appadurai, Steven C. Wallis, Maria Nunez-Nunez, Robert James Boots
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2016)
Article
Cardiac & Cardiovascular Systems
Bernie Bissett, Margot Green, Vince Marzano, Susannah Byrne, I. Anne Leditschke, Teresa Neernan, Robert Boots, Jennifer Paratz
Article
Critical Care Medicine
Hiran Bandeshe, Rob Boots, Joel Dulhunty, Rachael Dunlop, Anthony Holley, Paul Jarrett, Charles D. Gomersall, Jeff Lipman, Thomas Lo, Steven O'Donoghue, Jenny Paratz, David Paterson, Jason A. Roberts, Therese Starr, Di Stephens, Janine Stuart, Jane Thomas, Andrew Udy, Hayden White
JOURNAL OF CRITICAL CARE
(2016)
Correction
Critical Care Medicine
Hiran Bandeshe, Rob Boots, Joel Dulhunty, Rachael Dunlop, Anthony Holley, Paul Jarrett, Charles D. Gomersall, Jeff Lipman, Thomas Lo, Steven O'Donoghue, Jenny Paratz, David Paterson, Jason A. Roberts, Therese Starr, Di Stephens, Janine Stuart, Jane Thomas, Andrew Udy, Hayden White
JOURNAL OF CRITICAL CARE
(2016)
Article
Critical Care Medicine
Hiran Bandeshe, Rob Boots, Joel Dulhunty, Rachael Dunlop, Anthony Holley, Paul Jarrett, Charles D. Gomersall, Jeff Lipman, Thomas Lo, Steven O'Donoghue, Jenny Paratz, David Paterson, Jason A. Roberts, Therese Starr, Di Stephens, Janine Stuart, Jane Thomas, Andrew Udy, Hayden White
JOURNAL OF CRITICAL CARE
(2016)
Editorial Material
Critical Care Medicine
Rob Boots
NEUROCRITICAL CARE
(2016)
Article
Respiratory System
Bernie M. Bissett, I. Anne Leditschke, Teresa Neeman, Robert Boots, Jennifer Paratz
Editorial Material
Respiratory System
Jennifer D. Paratz, Robert J. Boots
JOURNAL OF THORACIC DISEASE
(2016)
Article
Clinical Neurology
Judith Bellapart, Kylie Cuthbertson, Kimble Dunster, Sara Diab, David G. Platts, O. Christopher Raffel, Levon Gabrielian, Adrian Barnett, Jenifer Paratz, Rob Boots, John F. Fraser
FRONTIERS IN NEUROLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Wei Lian Tan, Kristyan Guppy-Coles, Robert Boots, Sandhir Prasad, John Atherton, Paul Martin
Summary: This study aimed to determine the factors associated with subsequent atrial fibrillation (AF) diagnoses and other adverse outcomes in critical illness associated new onset AF (CI-NOAF) patients. The results showed that AF burden and left atrial size were independently associated with subsequent AF. It was also found that CI-NOAF is often under-recognized and subsequent AF diagnoses are common post-discharge.
Article
Critical Care Medicine
Rob Boots, Gabrielle Mead, Oliver Rawashdeh, Judith Bellapart, Shane Townsend, Jenny Paratz, Nicholas Garner, Pierre Clement, David Oddy
CRITICAL CARE AND RESUSCITATION
(2020)
Article
Critical Care Medicine
Goran Mitric, Andrew Udy, Hiran Bandeshe, Pierre Clement, Rob Boots