Article
Biochemistry & Molecular Biology
Agnieszka Olejnik, Anna Krzywonos-Zawadzka, Marta Banaszkiewicz, Iwona Bil-Lula
Summary: This study found that Klotho protein has a protective effect on cardiomyocytes during ischemia-reperfusion injury by inhibiting matrix metalloproteinase-mediated degradation of contractile proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monika Skrzypiec-Spring, Agnieszka Sapa-Wojciechowska, Alina Rak-Pasikowska, Maciej Kaczorowski, Iwona Bil-Lula, Agnieszka Halon, Adam Szelag
Summary: This study investigated the inhibitory effect of simvastatin, a Rho-associated protein kinase (RhoA/ROCK) signaling pathway inhibitor, on matrix metalloproteinase 2 (MMP-2) activity in a rat ischemia-reperfusion injury (I/Ri) model. The results showed that simvastatin improved the contractile function of the heart and reduced MMP-2 activity in heart tissue by inhibiting the RhoA/ROCK pathway. The protective effect of simvastatin on systolic function in the acute ischemia-reperfusion model is not related to reduced MMP-2 activation but is mediated through other mechanisms associated with RhoA/ROCK pathway inhibition.
Article
Andrology
Kemal Ayengin, Hamit Hakan Alp, Zubeyir Huyut, Serkan Yildirim, Fikret Altindag, Veli Avci
Summary: The study showed that coenzyme Q10 has a significant protective effect against testicular ischemia/reperfusion injury, reducing oxidative damage, pro-inflammatory cytokine levels, matrix metalloproteinase activity, and apoptosis.
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Review
Biochemistry & Molecular Biology
Elise Pretzsch, Hanno Niess, Najib Ben Khaled, Florian Boesch, Markus Guba, Jens Werner, Martin Angele, Irshad H. Chaudry
Summary: Hepatic ischemia-reperfusion injury is a major challenge in liver surgery and transplantation, and is associated with tumor growth and recurrence risk. Current therapeutic strategies have not shown protective effects in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Richi Nakatake, Mareike Schulz, Christina Kalvelage, Carina Benstoem, Rene H. Tolba
Summary: The study focused on inducible nitric oxide synthase (iNOS) as an early inflammatory response to hepatic ischaemia reperfusion injury (HIRI) and found that iNOS was upregulated in almost all HIRIs, with no direct associations of endothelial nitric oxide synthase (eNOS) or nitric oxide (NO) with iNOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mohammed Shah, Zhenhe He, Ali Rauf, Siavash B. Kalkhoran, Christina Mathisen Heiestad, Kare-Olav Stenslokken, Christopher R. Parish, Oliver Soehnlein, Sapna Arjun, Sean M. Davidson, Derek Yellon
Summary: This study found that histones released during myocardial infarction are toxic to cardiomyocytes, and this toxicity is independent of TLR4. Inhibiting the release of histones can reduce cardiomyocyte death, providing a new therapeutic opportunity for ischemia-reperfusion injury.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vijay Arruri, Anil K. Chokkalla, Soomin Jeong, Bharath Chelluboina, Suresh L. Mehta, Krishna Kumar Veeravalli, Raghu Vemuganti
Summary: The increased expression of MMP-12 has been found to mediate blood-brain barrier disruption after stroke, while MMP-12 knockdown protects the brain and promotes functional recovery in mice.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Necmiye Sengel, Zeynep Koksal, Ali Dogan Dursun, Omer Kurtipek, Saban Cem Sezen, Mustafa Arslan, Mustafa Kavutcu
Summary: This study aimed to investigate the protective effect of dexmedetomidine administered through different routes on kidney tissue in rats with spinal cord IR injury. The results showed that dexmedetomidine administered through different routes improved the damage caused by IR in kidney histopathology, with greater renoprotective effects observed when administered intravenously and intrathecally before IR in rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Materials Science, Multidisciplinary
Richard J. R. Kelwick, Alexander J. Webb, Yizhou Wang, Amelie Heliot, Fiona Allan, Aidan M. Emery, Michael R. Templeton, Paul S. Freemont
Summary: The ALPHA beads, containing a library of low-cost, biodegradable protease biosensors utilizing PhaC-reporter fusion proteins, can detect specific proteases in various samples and have the potential for use in resource-limited settings.
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Kaiyu Xu, Xuxuan Gao, Genghong Xia, Muxuan Chen, Nianyi Zeng, Shan Wang, Chao You, Xiaolin Tian, Huiling Di, Wenli Tang, Pan Li, Huidi Wang, Xiuli Zeng, Chuhong Tan, Fanguo Meng, Hailong Li, Yan He, Hongwei Zhou, Jia Yin
Summary: Stroke is a leading cause of death and disability worldwide, and neuroprotective approaches have been unsuccessful in clinical trials. This study reveals a reciprocal relationship between stroke and gut dysbiosis, with acute ischemic stroke triggering dysbiosis of the gut microbiome, exacerbating brain infarction. Administering certain treatments was able to alleviate post-stroke brain infarction, illustrating the translational value of the brain-gut axis in stroke treatment.
Article
Chemistry, Medicinal
Cansu Kaya, Jelena Konstantinovic, Andreas M. Kany, Anastasia Andreas, Jan S. Kramer, Steffen Brunst, Lilia Weizel, Marco J. Rotter, Denia Frank, Samir Yahiaoui, Rolf Mueller, Rolf W. Hartmann, Joerg Haupenthal, Ewgenij Proschak, Thomas A. Wichelhaus, Anna K. H. Hirsch
Summary: Drug-resistant pathogens pose a global challenge to public health, and metallo-beta-lactamases (MBLs) are enzymes that catalyze the hydrolysis of beta-lactam drugs, including carbapenems. We have identified a series of inhibitors that effectively inhibit the activity of B1 MBLs, restoring the effectiveness of current beta-lactam antibiotics. In experiments, one of the inhibitors significantly reduced the minimum inhibitory concentration of resistant Escherichia coli strains, and the combination with imipenem also increased the survival rate of infected larvae in a model.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Jiaqi Wu, Ming Li, Ang Li, Xunming Ji
Summary: This study utilized SymMap and UniProt platforms to investigate the neuroprotective effects of Salvia miltiorrhiza Bge. on stroke and its internal mechanisms, indicating that the main components of Salvia miltiorrhiza Bge. may regulate neurotransmitters and neurological function, providing new insights for the treatment of ischemic stroke.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ivan B. Filippenkov, Julia A. Remizova, Alina E. Denisova, Vasily V. Stavchansky, Ksenia D. Golovina, Leonid V. Gubsky, Svetlana A. Limborska, Lyudmila V. Dergunova
Summary: In this study, functional genetic analysis was performed on the contralateral hemisphere after ischemia-reperfusion injury, revealing complex bilateral reactions at the transcriptome level in the rat brain. It is believed that specific genome responses in the contralateral hemisphere and ischemic hemisphere may serve as a useful model for studying brain repair after stroke.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Kwang-Sub Kim, Sugeun Lee, Young-Lan Kwak
Summary: We investigated the impact of preoperative malnutrition on 1-year mortality in patients undergoing valvular heart surgery and found that preoperative malnutrition diagnosed using objective nutritional scores was significantly associated with higher mortality rates.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Bora Lee, Kwang-Sup Kim, Jae-Kwang Shim, Hye-Bin Kim, Byongnam Jun, Young-Lan Kwak
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Medicine, General & Internal
Seo Hee Ko, Jong-Wook Song, Jae-Kwang Shim, Sarah Soh, Young-Lan Kwak
Summary: This study found a relationship between perioperative rScO(2) and AKI after OPCAB. Mean rScO(2) during surgery was an independent predictor of AKI and could serve as an early marker of renal injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Myung Il Bae, Jae-Kwang Shim, Jong Wook Song, Seo Hee Ko, Young Seo Choi, Young -Lan Kwak
Summary: The study analyzed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and delta-NLR in cardiac patients undergoing off-pump coronary artery bypass (OPCAB) surgery. The results showed that preoperative NLR and delta-NLR were significantly associated with days alive and out of hospital (DAOH), and delta-NLR was an independent risk factor for long-term mortality. These findings highlight the importance of NLR and delta-NLR in risk assessment and perioperative management.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Anesthesiology
Jae-Kwang Shim, Kwang-Sub Kim, Pierre Couture, Andre Denault, Young-Lan Kwak, Kyung-Jong Yoo, Young-Nam Youn
Summary: Off-pump coronary surgery requires careful management of cardiac displacement and hemodynamics to avoid complications and poor outcomes. Objective hemodynamic targets, such as maintaining mean arterial pressure and venous oxygen saturation within specific ranges, must be considered before the surgery. Transesophageal echocardiography should be used to assess for any potential complications and ensure that the patient can tolerate the procedure. Careful inspection of the ascending aorta is also necessary to prevent embolism.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Kyuho Lee, Kwang-Sub Kim, Jong-Kwang Park, Jun Hyug Choi, Young -Lan Kwak, Jae-Kwang Shim
Summary: This study aimed to investigate the association between transient hemodynamic deterioration during left circumflex artery grafting and the occurrence of composite of morbidity endpoints in off-pump coronary artery bypass surgery (OPCAB). The study found that mixed venous oxygen saturation (SvO2) < 60% during LCX grafting was significantly associated with the composite of morbidity endpoints. Pre-operative anemia was identified as a predictor of SvO2 < 60% during LCX grafting. This highlights the prognostic importance of this transient deterioration in oxygen supply-demand balance.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Medicine, General & Internal
Jin Ha Park, So Yeon Kim, Jin Sun Cho, Dongkwan Shin, Sung Yeon Ham, Hyesu Kim, Young -Lan Kwak
Summary: This study aimed to investigate the incidence of eGFR6m <60 and identify the risk factors for its occurrence in living kidney donors. The results showed that older age, history of hypertension, lower preoperative eGFR, and greater ACr2_pre were associated with the occurrence of eGFR6m <60. The combination of preoperative eGFR and ACr2_pre had the highest predictive power for eGFR6m <60.
YONSEI MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Seung Hwan Song, Duk Hwan Moon, Yon Hee Shim, Hyunjoo Jung, Sungsoo Lee
Summary: This study aimed to evaluate the efficacy of intraoperative cryoanalgesia during MIRPE. The results of the retrospective analysis on 64 patients showed that cryoanalgesia group had lower pain scores, shorter postoperative hospital stay, and lower oral opioid consumption compared with the epidural analgesia group.