Review
Cell Biology
Chad A. Sallaberry, Barbie J. Voss, Jaroslaw Majewski, Jacek Biernat, Eckhard Mandelkow, Eva Y. Chi, Crystal M. Vander Zanden
Summary: Misfolded tau protein is associated with various neurodegenerative diseases, particularly due to electrostatic interactions with anionic cellular membranes and membrane proteins, leading to the formation of reversible condensates and toxic oligomers at the membrane surface. Emerging evidence suggests that polyanionic membranes may serve as a site for phase-separated tau condensation, potentially regulating tau folding/misfolding and directing tau for native membrane-mediated functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhanbin Tang, Jingwei Cao, Jialin Yao, Xuehui Fan, Jingkun Zhao, Mianqiao Zhao, Qiong Duan, Baichao Han, Shurong Duan
Summary: The study suggests that KDM1A can enhance the expression of METTL3, thereby promoting autophagic clearance of p-Tau through the m6A-dependent regulation of STUB1, and ultimately ameliorating Alzheimer's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Min Liu, Wen Zhang, Min Li, Jiaxing Feng, Wenjun Kuang, Xiying Chen, Feng Yang, Qiang Sun, Zhangqi Xu, Jianfeng Hua, Chunxia Yang, Wei Liu, Qiang Shu, Yuehong Yang, Tianhua Zhou, Shanshan Xie
Summary: Autophagy plays a crucial role in promoting the degradation of CP110 at mother centrioles, with NudCL2 identified as an important autophagy receptor in this process. This selective degradation is essential for ciliogenesis, which is crucial for vertebrate embryo development.
Article
Biochemistry & Molecular Biology
Alice Anzalone, Alexandros Mosca, Giulio Dimaria, Daniele Nicotra, Matilde Tessitori, Grete Francesca Privitera, Alfredo Pulvirenti, Cherubino Leonardi, Vittoria Catara
Summary: This study compares the root microbiome of tomatoes grown in two cultivation methods and finds that the microbiome is mainly influenced by the substrate or soil, with significant differences in bacterial communities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Jichao Zhang, Wei Xiong, Yongju Wen, Xuewen Fu, Xiaoxia Lu, Guolin Zhang, Chun Wang
Summary: The prenylation of phenolic substrates promoted by magnesium dicarboxylates was investigated in this study. It was found that substrates with electron-donating group(s) yielded better results than those with electron-withdrawing group(s). Different solvents, such as MeCN and DMF, influenced the conversion and regio-selectivity of the reaction. Mechanistic study showed that the nucleophilic addition/substitution of the phenolic substrate to the alkyl halide occurred in the presence of the magnesium dicarboxylates. The method was successfully applied in the total synthesis of icaritin with a total yield of 33%.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Lily Liu, Peifu Wu, Fenfen Chen, Jielong Zhou, Aiwei Guo, Kerong Shi, Qin Zhang
Summary: The study reveals significant impacts of gut microbiome on milk fat synthesis in Zhongdian yak cows, especially interactions between Firmicutes-myristic acid and Proteobacteria-choline. These interactions may be the main contributors to higher efficiency in milk fat production in Zhongdian yak cows.
Article
Polymer Science
Andrew W. Kelly, Joseph V. Handy, Aaron D. Nicholas, Francis H. Barnes, Howard H. Patterson, Lukasz Wojtas, Robert D. Pike
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2017)
Article
Chemistry, Physical
Aaron D. Nicholas, Brooke M. Otten, Gerardo Ayala, James Hutchinson, Lukasz Wojtas, Mohammad A. Omary, Robert D. Pike, Howard H. Patterson
JOURNAL OF PHYSICAL CHEMISTRY C
(2017)
Article
Chemistry, Inorganic & Nuclear
Randy W. Larsen, Lukasz Wojtas
JOURNAL OF SOLID STATE CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Peng Teng, Ning Ma, Darrell Cole Cerrato, Fengyu She, Timothy Odom, Xiang Wang, Li June Ming, Arjan van der Vaart, Lukasz Wojtas, Hai Xu, Jianfeng Cai
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Sourav Chakraborty, Wei Hong, Kevin J. Endres, Ting-Zheng Xie, Lukasz Wojtas, Charles N. Moorefield, Chrys Wesdemiotis, George R. Newkome
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Huiling Jiang, Kai Lang, Hongjian Lu, Lukasz Wojtas, X. Peter Zhang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Qi Sun, Briana Aguila, Jason Perman, Lyndsey D. Earl, Carter W. Abney, Yuchuan Cheng, Hao Wei, Nicholas Nguyen, Lukasz Wojtas, Shengqian Ma
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Jeremy D. Baker, Lindsey B. Shelton, Dali Zheng, Filippo Favretto, Bryce A. Nordhues, April Darling, Leia E. Sullivan, Zheying Sun, Parth K. Solanki, Mackenzie D. Martin, Amirthaa Suntharalingam, Jonathan J. Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N. Uversky, Markus Zweckstetter, Chad A. Dickey, John Koren, Laura J. Blair
Article
Chemistry, Medicinal
Maryam Alborz, Aliasghar Jarrahpour, Roya Pournejati, Hamid Reza Karbalaei-Heidari, Veronique Sinou, Christine Latour, Jean Michel Brunel, Hashem Sharghi, Mandi Aberi, Edward Turos, Lukasz Wojtas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin Abner, Maj-Linda B. Selenica, Daniel C. Lee
Summary: The study reveals an interaction between polyamine metabolism, behavioral impairment, and tau pathology. Dysregulation of polyamine metabolism is associated with tau deposition and cognitive/affective behavioral impairments, with different effects observed for higher-order polyamines and acetylpolyamines on tau seeding and oligomerization. The tau-induced polyamine stress response affects disease progression and may offer potential targets for treating tauopathies, including Alzheimer's disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
April L. Darling, Jan Dahrendorff, Stefan G. Creodore, Chad A. Dickey, Laura J. Blair, Vladimir N. Uversky
Summary: Alzheimer's disease is a progressive and fatal neurodegenerative disease with no cure, characterized by the aggregation of tau protein. The study demonstrates that Hsp22 can prevent tau aggregation in vitro and modulate its liquid-liquid phase separation behavior.
Review
Biochemistry & Molecular Biology
April L. Darling, James Shorter
Summary: Protein aggregation is a hallmark of neurodegenerative diseases, but the mechanisms behind pathogenic aggregation remain unclear. Recent studies show that certain pathological proteins linked to neurodegenerative diseases can undergo liquid-liquid phase separation under physiological conditions, potentially leading to toxicity. Therapeutic strategies targeting aberrant phase transitions may offer a way to mitigate the toxicity and aggregation seen in these diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Marangelie Criado-Marrero, Danielle M. Blazier, Lauren A. Gould, Niat T. Gebru, Santiago Rodriguez Ospina, Debra S. Armendariz, April L. Darling, David Beaulieu-Abdelahad, Laura J. Blair
Summary: Tau accumulation and loss of neurons are associated with Alzheimer's disease. It has been found that reducing the UPR-induced transcription factor CHOP can mitigate tau-mediated neurotoxicity. However, the contribution of ER stress and CHOP upregulation to tau-induced neuronal death in Alzheimer's disease is still unknown.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shannon E. Hill, David Beaulieu-Abdelahad, Andrea Lemus, Jack M. Webster, Santiago Rodriguez Ospina, April L. Darling, Mackenzie D. Martin, Shreya Patel, Liznair Bridenstine, Ronald Swonger, Steven Paul, Roy Blackburn, Laurent Calcul, Chad A. Dickey, James W. Leahy, Laura J. Blair
Summary: The accumulation and aggregation of tau protein in neuronal tangles are associated with various neurodegenerative diseases. The heat shock protein 70 (Hsp70) family of chaperones can bind to tau and regulate its clearance and aggregation. This study synthesized and evaluated eight analogs of the rhodacyanine inhibitor JG98, finding that they reduced tau accumulation in cultured cells. One of the compounds, AL69, showed promising potential in reducing phosphorylated tau accumulation in an ex vivo brain slice model.
ACS CHEMICAL BIOLOGY
(2023)