Review
Cell Biology
Mariacristina Mazzitelli, Peyton Presto, Nico Antenucci, Shakira Meltan, Volker Neugebauer
Summary: Metabotropic glutamate receptors (mGluR) are important in the nervous system and have implications in various pathological conditions including pain. Pharmacological manipulation of mGluR subtypes may be a promising approach for the treatment of pain and other disorders.
Article
Chemistry, Medicinal
Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M. Thal, Manuela Joerg, Ben Capuano, Celine Valant, Peter J. Scammells
Summary: Chronic pain and depression often coexist and the use of mu-opioid receptor-based medications can lead to severe side effects. This study explores the potential of using delta-opioid receptor as an alternative target for treating chronic pain and depression, with a focus on compounds that enhance specific downstream signaling attributes. Compound 6g shows potential in enhancing ERK1/2 phosphorylation signaling, while compound 11c exhibits a trend towards inhibiting cAMP signaling. These findings provide valuable insights for the design of prospective therapeutics.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elsa Cortes-Montero, Maria Rodriguez-Munoz, M. Carmen Ruiz-Cantero, Enrique J. Cobos, Pilar Sanchez-Blazquez, Javier Garzon-Nino
Summary: TRPA1 channels are involved in nociceptive signaling, forming functional associations with MORs and NMDARs to promote pain transmission and modulate analgesic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Lukas Gorecki, Anna Misiachna, Jiri Damborsky, Rafael Dolezal, Jan Korabecny, Lada Cejkova, Kristina Hakenova, Marketa Chvojkova, Jana Zdarova Karasova, Lukas Prchal, Martin Novak, Marharyta Kolcheva, Stepan Kortus, Karel Vales, Martin Horak, Ondrej Soukup
Summary: Research shows that tacrine and its derivatives have clinical benefits for neurodegenerative diseases, potentially due to their NMDAR-antagonizing activity. Evaluation of 30 tacrine derivatives revealed varying blocking efficacy on different receptors, pointing towards subtype-specific inhibition of NMDARs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Anesthesiology
Erick J. Rodriguez-Palma, Yarim E. De la Luz-cuellar, Ana M. Islas-Espinoza, Adalberto E. Felix-Leyva, Stephanie Shiers, Guadalupe Garcia, Jorge E. Torres-Lopez, Rodolfo Delgado-Lezama, Janet Murbartian, Theodore J. Price, Vinicio Granados-Soto
Summary: The loss of GABAergic inhibition contributes to neuropathic pain. Activation of GABA(A) receptors can help reduce neuropathic pain. This study explores the role of the spinal a(6)-containing GABA(A) receptor in neuropathic pain and its potential as a treatment target. Results show that blocking or silencing the a(6)-containing GABA(A) receptor induces hypersensitivity and pain in female rats. The a(6) subunit is expressed in certain neurons and its expression is reduced after nerve injury. Positive allosteric modulators of the a(6)-containing GABA(A) receptor can alleviate allodynia and nociceptive behaviors in female rats. The a(6) subunit is also found in humans. These findings suggest that the spinal a(6)-containing GABA(A) receptor has a sex-specific antinociceptive role and may be a potential target for neuropathic pain treatment.
Article
Biochemistry & Molecular Biology
Ronald Melki
Summary: This review explores the link between protein aggregates and neurodegenerative diseases, as well as the reason why the aggregation of the same protein leads to different pathologies.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Surgery
Mohammadreza Tabary, Armin Aryannejad, Nafise Noroozi, Setare Iranshahi, Razieh Mohammad Jafari, Baharnaz Mashinchi, Seyed Mohammad Tavangar, Farnaz Araghi, Ahmad Reza Dehpour
Summary: The study demonstrates that colchicine can significantly improve skin flap survival in rats through the glutamate pathway and NMDA receptors, suggesting a potential application value of colchicine in preventing flap necrosis.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Rosa Rodriguez-Rodriguez, Nieves Hernandez-Leon, Lucio Diaz-Flores Jr, Jose Luis Carrasco
Summary: This study focuses on CD34+ stromal cells/telocytes in pathological skin, exploring their characteristics and distribution in various skin diseases and tumors. CD34+ stromal cells play different roles in normal and diseased skin, impacting the pathophysiology of fibrosing/sclerosing diseases, metabolic degenerative processes, dermatitis, skin tumors, and more. Their presence, absence, or altered expression levels can serve as important markers for diagnosing and understanding different skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao Xu
Summary: The study demonstrates that mGluR5 expressed in the NAc can modulate pain and social avoidance behavior induced by chronic social defeat stress. Overexpression of mGluR5 prevents the development of depressive-like behaviors and pain in susceptible mice, while knockdown of mGluR5 exacerbates these symptoms. Additionally, mGluR5-mediated eCB production in the NAc relieves stress-induced depressive-like behaviors and pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Serena Notartomaso, Serena Boccella, N. Antenucci, Flavia Ricciardi, Francesco Fazio, F. Liberatore, P. Scarselli, M. Scioli, Giada Mascio, V. Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Sabatino Maione, Livio Luongo
Summary: Cinnabarinic acid (CA), a trace metabolite of kynurenine, activates mGlu4 and Ah receptors and has analgesic effects on inflammatory and neuropathic pain. This study demonstrates that the modulation of pain thresholds by CA depends on the recruitment of mGlu4 and Ah receptors.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Geehoon Chung, Yeong-Chan Yun, Chae Young Kim, Sun Kwang Kim, Sang Jeong Kim
Summary: This study found that the levels of mGluR5 in the S1DZ were significantly upregulated in a rat model of neuropathic pain. Pharmacological deactivation of mGluR5 ameliorated the symptoms of neuropathic allodynia and reduced the behavioral response to cold stimuli. In addition, this treatment also relieved the tonic-aversive state of chronic neuropathic pain.
Article
Medicine, General & Internal
Julia Stuhlreyer, Marie Schwartz, Till Friedheim, Christian Zollner, Regine Klinger
Summary: This article introduces the severity of chronic lower back pain (CLBP) and the current ineffective treatments. The authors propose three promising treatment possibilities and hypothesize that treatment expectations can be influenced through social observation to improve treatment outcome. A clinical trial will be conducted to test this hypothesis.
Article
Health Care Sciences & Services
Paul Perkins, Anne Parkinson, Rob Hebdon, Ralph K. Akyea
Summary: This study investigated how and why patients take their strong opioids as unmeasured sips. The results showed that only a small number of patients were taking the correct dose, while many adjusted the dose based on the severity of their pain. Convenience, confusion about the correct dose, and issues with spoons were the main reasons for choosing to sip. Understanding patients' behavior and reasons for sipping can help clinicians better manage their pain.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Review
Neurosciences
Jinyue Liu, Shilin Jia, Fang Huang, Hongwen He, Wenguo Fan
Summary: This study reviewed the mechanisms of peripheral glutamate-mediated orofacial pain, the regulation of glutamate in the periphery, and the translation of these findings into pain treatments.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Optics
Young-Hoon Kim, Sungjin Kim, Arvin Kakekhani, Jinwoo Park, Jaehyeok Park, Yong-Hee Lee, Hengxing Xu, Satyawan Nagane, Robert B. Wexler, Dong-Hyeok Kim, Seung Hyeon Jo, Laura Martinez-Sarti, Peng Tan, Aditya Sadhanala, Gyeong-Su Park, Young-Woon Kim, Bin Hu, Henk J. Bolink, Seunghyup Yoo, Richard H. Friend, Andrew M. Rappe, Tae-Woo Lee
Summary: In this study, a one-dopant alloying strategy was employed to enhance electroluminescence efficiencies of metal halide perovskite nanocrystals (PNCs) by reducing defect formation and enhancing charge carrier confinement. Surface-stabilizing agents and bromide vacancy healing agents were utilized to decrease defect density and improve carrier confinement, resulting in significant enhancement in performance.
Article
Physics, Multidisciplinary
Yu Wang, Peng Tan, Zhongxiang Zhou, Xiaolin Huang, Chengpeng Hu, Xiangda Meng, Fei Huang, Jing Wang, Hao Tian
Summary: The study focused on regulating and controlling the space-charge field based on Mn-doped KTN single crystal using digital holographic microscopy, achieving beam deflection. The realized deflector has a maximum deflection angle of 0.3 degrees and maintains good frequency-response characteristics up to 50 kHz. This work provides guidance for optical functional devices based on engineering distribution of a space-charge field.
NEW JOURNAL OF PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Yu Wang, Peng Tan, Xiangda Meng, Zhongxiang Zhou, Xiaolin Huang, Chengpeng Hu, Fei Huang, Jing Wang, Hao Tian
Summary: This study investigates the effects of Mn doping on local heterogeneity and piezoelectric properties in KTN, showing that Mn doping can enhance the piezoelectric performance by increasing local heterogeneity and reducing domain sizes. The results provide valuable insights for optimizing and designing material properties based on the impact of Mn dopants on KTN properties.
Article
Thermodynamics
Tianlun Huang, Penghui Tan, Yun Zhang, Zhigao Huang, Huamin Zhou
Summary: The floatation nozzle is a key component for manufacturing high-performance substrates. Increasing heat transfer uniformity can improve product quality, and the revised uniformity indicator has increased accuracy. Factors affecting heat transfer and pressure uniformity include edge effects, turbulent intermittence, and interaction between adjacent jets. The floatation nozzle with effusion holes shows better comprehensive performance compared to other types.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Engineering, Electrical & Electronic
P. T. Ng, F. Rivai, A. C. T. Quah, P. K. Tan, S. L. Ting, K. Menon
Summary: This paper proposes a systematic two-step isolation approach using nanoprobing techniques to effectively localize IPO defects. By utilizing inter-poly leakage characterization and Electron Beam Absorbed Current (EBAC) analysis, IPO defects can be accurately located at the nanoscale level.
MICROELECTRONICS RELIABILITY
(2021)
Article
Optics
Jing Wang, Peng Tan, Shuai Li, Guanchao Wang, Wenpeng Guo, Zhongxiang Zhou, Hao Tian
Summary: This study presents a tunable polarization-independent plasmon-induced transparency (PIT) metasurface based on connected half-ring and split-ring resonators, working in the terahertz band. By connecting the ring resonators and split-ring resonators, magnetic attenuation is avoided and a stronger PIT effect is achieved. The design could provide significant guidance in multifunctional active devices for terahertz communication.
Article
Optics
Zhou Yuan, Peng Lixin, Tan Peng, Zhang Zhiguo
Summary: The LIR thermometry based on CaWO4:Tb3+ utilizes a combination of ground and excited states absorptions to measure temperature by analyzing the luminescence intensity ratio under specific wavelengths, achieving high sensitivity and accuracy.
Article
Plant Sciences
Ke Teng, Penghui Tan, Jin Guan, Di Dong, Lingyun Liu, Yidi Guo, Weier Guo, Yue Yuesen, Xifeng Fan, Juying Wu
Summary: ZjNYC1 gene encodes a chlorophyll b reductase responsible for catalyzing chlorophyll b degradation and maintaining photosystem stability. Overexpression of ZjNYC1 accelerates chlorophyll degradation, promotes senescence, and negatively affects photosystem integrity and functionality.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Xiaolin Huang, Peng Tan, Yu Wang, Yao Zhang, Xing Wen, Guanchao Wang, Zhongxiang Zhou, Hao Tian
Summary: This study provides an effective approach to improving the EC performance of ferroelectrics with pronounced anisotropy by investigating the impact of anisotropic domain responses on the electrocaloric effect.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Multidisciplinary Sciences
Xin Liu, Peng Tan, Xue Ma, Danyang Wang, Xinyu Jin, Yao Liu, Bin Xu, Liao Qiao, Chaorui Qiu, Bo Wang, Weigang Zhao, Chaojie Wei, Kexin Song, Haisheng Guo, Xudong Li, Sean Li, Xiaoyong Wei, Long-Qing Chen, Zhuo Xu, Fei Li, Hao Tian, Shujun Zhang
Summary: By synergistically designing the ferroelectric phase, crystal orientation, and poling technique, we developed crystals with extremely high electro-optic coefficients and eliminated light-scattering domain walls, achieving high transmittance and superior electro-optic performance.
Article
Optics
Wenpeng Guo, Peng Tan, Jing Wang, Li Li, Shuai Li, Guanchao Wang, Zhongxiang Zhou, Hao Tian
Summary: This study proposes a terahertz band polarization conversion metasurface based on dislocation-induced anisotropy. Numerical simulations demonstrate the successful conversion between orthogonal linearly polarized light and orthogonal circularly polarized light, as well as between linearly polarized light and circularly polarized light. Additionally, multifunctional polarization conversion can be achieved by different structures of the bilayer metasurface. The proposed design shows significant potential for applications in terahertz communications.
Article
Physics, Applied
Xing Wen, Yu Wang, Xiangda Meng, Xiaolin Huang, Bohan Xing, Xinyu Jin, Zuoren Xiong, Chengpeng Hu, Peng Tan, Hao Tian
Summary: High-performance electro-optic (EO) crystals, such as potassium tantalate niobate (KTN), with ultrahigh quadratic electro-optic coefficient and wide transparency range, have excellent QEO properties due to polar nanoregion (PNR)-related polar units. However, the relationship between strain behavior and QEO properties in nanodisordered KTN crystals has rarely been studied. This research establishes the coupling relation between strain behavior and QEO properties, showing that strain-induced QEO response significantly affects the QEO properties. The response of PNRs is shown to be an important reason for the enhancement of the QEO response of KTN crystals.
APPLIED PHYSICS LETTERS
(2023)
Proceedings Paper
Computer Science, Information Systems
Mohit K. Sharma, Tan Peng Hui, Ernest Kurniawan, Sun Sumei
Summary: In this work, a reinforcement learning based model-free approach is developed to minimize packet drop probability in joint packet scheduling and rate adaptation. Through simulations, it is observed that the policy learned using prioritized experience replay leads to a 3-5% lower packet drop probability compared to basic reinforcement learning methods.
2021 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS WORKSHOPS (ICC WORKSHOPS)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
P. K. Tan, S. L. Ting, Y. L. Pan, N. Y. Xu, D. Nagalingam, H. H. W. Thoungh, H. Kyaw, H. Tan, K. Menon, R. Fransiscus, A. Quah, P. T. Ng, S. M. Parab, C. Q. Chen
Summary: With the scaling down of semiconductor devices, physical failure analysis becomes more challenging, especially on vertical short failures in new processes and technology nodes. Vertical shorts in Back-End-of-Line on new products are more common in development stages than in mature production devices. This paper discusses failure analysis on different types of vertical short failures found in production wafers.
2021 IEEE INTERNATIONAL SYMPOSIUM ON THE PHYSICAL AND FAILURE ANALYSIS OF INTEGRATED CIRCUITS (IPFA)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Amnart Boonkajay, Peng Hui Tan, Lee Kee Goh, Syed Naveen Altaf Ahmed, Sumei Sun
Summary: This paper proposes a method to enhance the resilience of Wi-SUN AMI network by deploying NB-IoT interface and using ResiLite as an emergency gateway, with an algorithm considering path diversity and cluster closeness. Simulation results show that optimal ResiLite placement significantly improves network resilience.
2021 IEEE 93RD VEHICULAR TECHNOLOGY CONFERENCE (VTC2021-SPRING)
(2021)
