期刊
ANALYTICAL CHEMISTRY
卷 87, 期 19, 页码 9752-9760出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b01915
关键词
-
资金
- National Natural Science Foundation of China [31470971, 21375106, 21175107, 31100726]
- China Scholarship Council [201208610047]
- Ministry of Education of the People's Republic of China
- Northwest AF University
The development and application of miniaturized platforms with the capability for microscale and dynamic control of biornimetic and high-throughput three-dimensional (3D) culture plays a crucial role in biological research. In this study, pneumatic microstructure-based microfluidics was used to systematically demonstrate 3D tumor culture under various culture conditions. We also demonstrated the reusability of the fabrication-optimized pneumatic device for high-throughput cell manipulation and 3D tumor culture. This microfluidic system provides remarkably long-term (over 1 month) and cyclic stability. Furthermore, temporal and high-throughput monitoring of tumor response to evaluate the therapeutic efficacy of different chemotherapies, was achieved based on the robust culture. This advancement in microfluidics has potential applications in the fields of tissue engineering, tumor biology, and clinical medicine; it also provides new insight into the construction of high-performance and recyclable microplatforms for cancer research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据