期刊
BRIEFINGS IN BIOINFORMATICS
卷 15, 期 3, 页码 419-430出版社
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbt078
关键词
epigenetics; nucleosome; DNA sequence; alignment-free method; machine learning
资金
- NIH [HG005085]
Epigenetic mechanisms play an important role in the regulation of cell type-specific gene activities, yet how epigenetic patterns are established and maintained remains poorly understood. Recent studies have supported a role of DNA sequences in recruitment of epigenetic regulators. Alignment-free methods have been applied to identify distinct sequence features that are associated with epigenetic patterns and to predict epigenomic profiles. Here, we review recent advances in such applications, including the methods to map DNA sequence to feature space, sequence comparison and prediction models. Computational studies using these methods have provided important insights into the epigenetic regulatory mechanisms.
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