期刊
BRIEFINGS IN BIOINFORMATICS
卷 11, 期 1, 页码 142-152出版社
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbp038
关键词
computational biology; multi-scale modelling; molecular dynamics; cellular automata; complex networks
资金
- European Commission [033664, 027446]
The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.
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