Article
Oncology
Maha S. Al-Keilani, Roba Bdeir, Rana I. Elstaty, Mohammad A. Alqudah
Summary: This study investigates the prognostic significance of Substance P (SP) and Pyruvate Kinase M2 (PKM2) in combination with Neurokinin 1 receptor (NK1R) and Ki-67 in hormone receptor negative (HR-ve) breast cancer. The results show that SP is associated with NK1R and Ki-67 expression levels, and PKM2 is associated with SP expression level. The combined expression of these markers can predict survival in HR-ve breast cancer patients.
Article
Oncology
Zhihua Li, Fang Li, Cheng Pan, Zhicheng He, Xianglong Pan, Quan Zhu, Weibing Wu, Liang Chen
Summary: Ki-67 expression varied significantly across histological subtypes of LUAD, with solid-predominant adenocarcinoma (SPA) showing the highest expression level. Ki-67 expression level and tumor size contributed to the survival differences between LUAD histological subtypes.
Article
Pediatrics
Hsin-Ju Lee, Chun-Chun Gau, Wan-Fang Lee, Wen- Lee, Jing-Long Huang, Shih-Hsiang Chen, Ho-Yu Yeh, Chi-Jou Liang, Shih-Hang Fu
Summary: This study aimed to investigate whether non-radioactive assays can be used to quantitatively detect lymphocyte proliferation, establishing normal ranges of mitogen-stimulated lymphocyte proliferation for comparison and diagnosis references.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Omaditya Khanna, Anahita Fathi Kazerooni, Sherjeel Arif, Aria Mahtabfar, Arbaz A. Momin, Carrie E. Andrews, Karim Hafazalla, Michael P. Baldassari, Lohit Velagapudi, Jose A. Garcia, Chiharu Sako, Christopher J. Farrell, James J. Evans, Kevin D. Judy, David W. Andrews, Adam E. Flanders, Wenyin Shi, Christos Davatzikos
Summary: In this study, the authors identified multiparametric MRI radiomic signatures of meningiomas using Ki-67 as a prognostic marker of clinical outcomes. They developed a machine learning algorithm to stratify meningiomas based on Ki-67 indices and found that the Ki-67 proliferation index can serve as a surrogate marker of increased meningioma aggressiveness independent of WHO grade. Machine learning using radiomic feature analysis may be used for the preoperative prediction of meningioma Ki-67, providing enhanced analytical insights to help improve diagnostic classification and guide patient-specific treatment strategies.
NEUROSURGICAL FOCUS
(2023)
Article
Medicine, General & Internal
Reiki Nishimura, Tomofumi Osako, Yasuhiro Okumura, Masahiro Nakano, Hiroko Otsuka, Mamiko Fujisue, Nobuyuki Arima
Summary: Menopausal status significantly correlates with breast cancer subtypes. TNBC is more frequently seen in postmenopausal patients. Premenopausal TNBC patients are more likely to have overexpression of p53 protein, a higher Ki-67 index value, and a higher nuclear grade. Menopausal status, nodal status, and tumor size are significant factors for DFS in TNBC cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Rosa Patruno, Giuseppe Passantino, Carmelo Laface, Antonella Tinelli, Alfredo Zito, Roberta Ruggieri, Francesco Luposella, Pietro Gadaleta, Mariarita Laforgia, Luca Lacitignola, Michele Ammendola, Girolamo Ranieri, Nicola Zizzo
Summary: The study focused on the correlation among microvascular density (MVD), endothelial area (EA), and Ki-67 proliferative index in tissue samples from cats affected by post-injection fibrosarcomas, aiming to demonstrate that cats may be a useful animal model for studying human diseases.
Review
Oncology
Brian S. Finkelman, Huina Zhang, David G. Hicks, Bradley M. Turner
Summary: The discovery of the Ki-67 antibody has played a significant role in determining breast cancer recurrence risk and response to chemotherapy. However, inconsistent results between pathologists have limited its use as a prognostic and predictive marker. This review highlights the historical evolution of Ki-67 in breast cancer and discusses its future as a clinical marker, emphasizing the need for standardization and consensus.
Article
Medicine, General & Internal
Sevket Baris Morkavuk, Murat Guner, Serdar Culcu, Aydan Eroglu, Sancar Bayar, Ali Ekrem Unal
Summary: The study evaluated the relationship between LVI and molecular subtypes in invasive breast cancers, finding that LVI may impact molecular subtypes and suggesting that histopathological factors can influence tumor biology in a heterogeneous disease like breast cancer.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Iva Busic-Pavlek, Ivo Dumic-Cule, Lucija Kovacevic, Milan Milosevic, Petra Delimar, Lea Korsa, Zlatko Marusic, Maja Prutki
Summary: The calcium-sensing receptor (CaSR) is important in maintaining calcium balance and altered signaling through CaSR is associated with the development of various tumors including colorectal and breast tumors. A retrospective study involving 79 patients with invasive breast carcinoma explored the expression of CaSR in breast cancer. The study found that higher CaSR expression was correlated with larger tumor size, presence of HER2 receptors, lymph node involvement, distant metastasis, and increased Ki-67 proliferation index. This suggests that higher CaSR expression may indicate a poor prognosis and treatment outcome in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Review
Cell Biology
Nuria Andres-Sanchez, Daniel Fisher, Liliana Krasinska
Summary: Ki-67 is a cell proliferation biomarker widely used in histopathology. Although its expression and localization throughout the cell cycle have been well characterized, its function and molecular mechanisms are not fully understood. Recent studies have revealed that Ki-67 plays important roles in localizing nucleolar material to the mitotic chromosome periphery and structuring perinucleolar heterochromatin, and it is also implicated in cancer development. However, its mechanisms of action remain unclear.
JOURNAL OF CELL SCIENCE
(2022)
Article
Clinical Neurology
Hirotaka Fudaba, Yasutomo Momii, Hiroyuki Matsuta, Kouhei Onishi, Yukari Kawasaki, Kenji Sugita, Tsuyoshi Shimomura, Minoru Fujiki
Summary: Pulsed arterial spin-labeling, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy are useful for predicting glioma survival, particularly the parameters obtained in 3-Tesla MRI, including the rCBF ratio and Ki-67 labeling index. High rCBF ratios and Ki-67 labeling indices are associated with shorter overall survival durations in patients with cerebral glioblastomas.
WORLD NEUROSURGERY
(2021)
Article
Cell Biology
Koji Okudela, Tetsukan Woo, Yusuke Saigusa, Hiromasa Arai, Mai Matsumura, Hideaki Mitsui, Misaki Sugiyama, Motoki Sekiya, Yoshihiro Ishikawa, Hisashi Oshiro, Yoichi Kameda, Kenichi Ohashi
Summary: This study optimized a procedure for measuring the Ki-67 index in lung adenocarcinoma and established the best cut-off value. Using the SP6 antibody for immunohistochemical staining, they successfully developed an optimal procedure for determining the Ki-67 labeling index. They identified an optimal cut-off value of 0.12 and achieved a coverage probability >70% and a confidence interval of <0.05 in over 90% of cases.
Article
Immunology
Tiina Vesterinen, Jenni Saila, Sami Blom, Mirkka Pennanen, Helena Leijon, Johanna Arola
Summary: A deep learning-based Ki-67 PI algorithm (KAI) was developed to objectively calculate the Ki-67 proliferation index in neuroendocrine tumors (NETs). The algorithm yields results similar to human observers and can assist in the assessment of Ki-67 PI in NETs.
Article
Medicine, Research & Experimental
Adem Deligonul, Serkan Yazici, Mine Ozsen, Sibel Kahraman Cetintas, Ulviye Yalcinkaya, Ahmet Bilgehan Sahin, Ozgur Tanriverdi, Sibel Oyucu Orhan, Birol Ocak, Erdem Cubukcu, Ramazan Kahveci, Turkkan Evrensel
Summary: This study retrospectively analyzed data from 45 patients with DFSP and found that the Ki-67 proliferation index was the only independent predictor for RFS, highlighting its potential usefulness in identifying DFSP patients at a higher risk of disease recurrence.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Surgery
R. Lewis, B. Forman, M. Preston, E. Heidel, B. Alvoid-Preston, B. Ramshaw
Summary: This study attempted to improve abdominal wall reconstruction surgery by using a resorbable synthetic scaffold. The results showed that there were no mesh-related complications and no mesh removals required, indicating an improvement in value and a durable repair.
Article
Dentistry, Oral Surgery & Medicine
Mina D. Fahmy, Devin Clegg, Alexandra Belcastro, Blaine D. Smith, R. Eric Heidel, Eric R. Carlson, Benjamin Hechler
Summary: This study aimed to determine the association between pain complaints and perineural invasion in patients with oropharyngeal squamous cell carcinoma. The results showed that otalgia is a preoperative predictor of perineural invasion and there is an increased occurrence of perineural invasion in patients with pain symptoms.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Information Science & Library Science
Kelsey Leonard Grabeel, R. Eric Heidel, Sandy Oelschlegel, Rima Rudd
Summary: A librarian-led task force at the University of Tennessee Medical Center evaluated the health literacy attributes of their medical center using a widely-used tool, which ultimately led to the tool's update. The collaborative process of updating the HLEHHC tool involved an extensive literature review, editing, and formulating changes to better assess the organization's accommodation of low health literacy patients. The assessment conducted by the task force is playing a role in shaping changes within the organization.
HEALTH INFORMATION AND LIBRARIES JOURNAL
(2022)
Article
Health Care Sciences & Services
R. Steve McCallum, Baileigh A. Kirkpatrick, Robert E. Heidel, Louis Rocconi, Chelsea N. Price, Kaylan N. Gee, James M. Lewis
Summary: This study constructed and validated a scale of emotional intelligence (EI) for the medical field, called SEF:MED. The scale was developed through surveys of resident physicians and found to have a three-factor solution. The SEF:MED scale provides valuable data for physicians and other medical professionals to consider their own well-being and its impact on patient care.
EVALUATION & THE HEALTH PROFESSIONS
(2022)
Article
Surgery
Skyler Brown, James McLoughlin, Andrew Russ, Mark Casillas, Jason Buehler, Robert E. Heidel, John R. Yates
Summary: This study retrospectively analyzed patients undergoing colorectal surgery and found that the use of alvimopan and lidocaine significantly improved gastrointestinal recovery time and reduced length of hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Sarah A. King, Christopher Harper, Lou M. Smith, David Crismon, Robert E. Heidel, Genevieve Hall, Zachary Beam, Brian J. Daley
Summary: This study retrospectively analyzed pain management and opioid use in patients with rib fractures. The study found that prescriber factors can affect the duration of opioid use, while lidocaine infusion can reduce dependence. It is recommended that prescribers pay attention to the daily equivalent opioid dose and number of pills in prescriptions, and early lidocaine infusion is recommended to reduce post-discharge opioid use.
Article
Primary Health Care
Rebecca K. Kemmet, Gregory H. Blake, Robert E. Heidel, G. Anthony Wilson
Summary: This study aimed to provide milestones for academic physicians and found significant associations between academic titles and competency domains, which could guide faculty development and mentorship.
Article
Substance Abuse
Rachel E. Barenie, Brian L. Winbigler, R. Eric Heidel, James S. Wheeler
Summary: This study assessed the accuracy of publicly-listed locator information for waivered practitioners and OTPs in the US. The findings showed that it was difficult to reach these practitioners and programs via phone, but they were easily found online and on state licensing board websites. When reached via phone, their contact information was very accurate.
Article
Microbiology
Petra Cerna, Ashley Ayoob, Caroline Baylor, Erin Champagne, Sandra Hazanow, Robert E. Heidel, Kimberly Wirth, Alfred M. Legendre, Danielle A. Gunn-Moore
Summary: Feline infectious peritonitis remains a challenge in feline medicine. Treatment with Polyprenyl Immunostimulant shows promise in enhancing the immune response. However, persistently low hematocrit and albumin:globulin ratio indicate a negative prognosis. Further studies are needed to establish optimal treatment protocols.
Article
Psychology, Clinical
Brett Salomon, Amy Howk, Robert Heidel, Catherine Lyndsay McKnight
Summary: This study aimed to investigate the impact of the COVID-19 pandemic on the presentation patterns and outcomes of trauma patients in East Tennessee. The results showed that after the stay-home orders, the trauma population was younger, more likely to be male, and had a higher rate of penetrating injuries. Additionally, patients were more likely to be admitted from the emergency department and less likely to be discharged directly to home.
Article
Pharmacology & Pharmacy
Blake R. Johnson, Andrea S. Franks, Laura N. Bullock, Danielle L. Dennis, R. Eric Heidel, Timothy H. Self
Summary: Pharmacist-led inhaler technique education leads to sustained improvements in inhaler administration skills among acute care pulmonary nursing staff.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
Article
Information Science & Library Science
Alexandria Quesenberry Wilson, Courtney Wombles, R. Eric Heidel, Kelsey Leonard Grabeel
Summary: This study examines the characteristics of health literacy publications authored by librarians from 2000 to 2020. Results show that librarian involvement in health literacy research has exponentially increased over the past two decades, particularly after 2014. Librarians demonstrate high productivity, multidisciplinary collaboration efforts, and consistent growth in their literature. However, further research is needed to explore the impact of librarians on health literacy that may not be reflected in well-indexed, peer-reviewed publications.
JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION
(2022)
Meeting Abstract
Critical Care Medicine
N. Sharma, M. K. Bhagat, T. M. Dudney, R. Dhand, B. T. Bevill, P. R. Branca, M. T. McCormack, R. E. Heidel, J. W. Green, F. J. Soto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Amy Weisman, Emily Martin, Robert Eric Heidel, Timothy G. Perk, Deepak Behera, Stephen Kennel, Jonathan Wall
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Education & Educational Research
Luci Olewinski, M. Alison Brooks, John Wilson, R. Eric Heidel, Andrew Watson
Summary: Most collegiate athletes do not wear helmets while riding scooters or mopeds, but helmet use is higher when there are coach's rules or laws in place.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2022)
