Article
Immunology
Zhongyun Chen, Yan Zhang, Lili Cui, Huijin Huang, Weibi Chen, Yingying Su
Summary: The study found that 34.2% of anti-NMDAR encephalitis patients were positive for anti-thyroid antibodies, which were more common in severe cases and correlated with poor prognosis and higher incidence of certain symptoms.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Piyu Parth Naik, Syed Nadir Farrukh
Summary: Alopecia Areata is an inflammatory disorder characterized by patchy non-scarring hair loss, likely caused by genetic susceptibility, autoimmunity, and stress. It has episodes of recurrent patterns and a strong association with hypothyroidism and Vitiligo.
POSTGRADUATE MEDICINE
(2021)
Article
Endocrinology & Metabolism
A. Brancatella, L. Torregrossa, N. Viola, D. Sgro, M. Casula, F. Basolo, G. Materazzi, M. Marino, C. Marcocci, F. Santini, F. Latrofa
Summary: The purpose of this study is to correlate laboratory and ultrasound characteristics of Graves' disease with its pathological features. The results showed that thyroid volume was positively correlated with levels of thyroid hormones, autoantibodies, and lymphocytic infiltration, but not with follicular hyperplasia.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Immunology
Tianyu Zhang, Feifei Hou, Dan Liu, Hangfan Zhou, Yutong Sun, Xiaoting Deng, Yiming Xu, Yanxuan Xiao, Xianwen Wang, Chuanji Wu, Yang Meng, Peiyang Yuan, Xuemei Qiu, Lu Ye, Yuye Liang, Wei Wei, Lu Jiang
Summary: This study found that the prevalence of Hashimoto's thyroiditis was higher in patients with oral lichen planus, especially in females. Female patients also had higher levels of auto-anti-thyroid antibodies. However, the clinical manifestations of oral lichen planus were not significantly correlated with the development of Hashimoto's thyroiditis or auto-anti-thyroid antibody levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Meng, Jing Lin, Jianxia Fan
Summary: This study aimed to identify the pregnancy-specific cutoff values for TPOAb positivity and TSH concentration associated with preterm delivery and develop a nomogram for risk prediction. The results showed that factors such as maternal age, history of premature delivery, elevated TSH concentration, and TPOAb positivity were associated with an increased risk of preterm delivery. The nomogram showed moderate discrimination and good calibration, indicating its potential as a clinical decision-making tool for predicting premature delivery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Nuria Chic, Francesco Schettini, Fara Braso-Maristany, Esther Sanfeliu, Barbara Adamo, Maria Vidal, Debora Martinez, Patricia Galvan, Blanca Gonzalez-Farre, Javier Cortes, Joaquin Gavila, Cristina Saura, Mafalda Oliveira, Sonia Pernas, Olga Martinez-Saez, Jesus Soberino, Eva Ciruelos, Lisa A. Carey, Montserrat Munoz, Charles M. Perou, Tomas Pascual, Meritxell Bellet, Aleix Prat
Summary: Chemotherapy has different biological effects on patients with hormone receptor-positive breast cancer with different menopausal statuses. Specific estrogen-regulated genes exhibited varied expression levels under different treatment regimens in these patients.
Article
Endocrinology & Metabolism
Dorina Ylli, Steven J. Soldin, Brian Stolze, Bin Wei, Girum Nigussie, Hung Nguyen, Damodara Rao Mendu, Mihriye Mete, Di Wu, Cristiane J. Gomes-Lima, Joanna Klubo-Gwiezdzinska, Kenneth D. Burman, Leonard Wartofsky
Summary: This study found that biotin intake can lead to variations in thyroid-related laboratory test results, especially in data measured on the Roche Cobas 6000 and Siemens IMMULITE 2000 platforms. Taking 10 mg of biotin per day can interfere with the measurement results of specific indices such as TSH, fT4, TT3, and Tg.
Article
Medicine, General & Internal
Hashem O. Zahra, Gamal A. Omran, Ahmed G. Gewely, Ahmed Fathy Eldehn, Walied Abdo, Ehab Kotb Elmahallawy, Tarek M. Okda
Summary: This study investigated the treatment methods and prognostic factors of WDTC patients, concluding that TG and TGAb are the most successful predictive factors.
Article
Medicine, General & Internal
Nan Jiang, Benzheng Jiao, Laney Zhang, Jialong Li, Yungeng Li, Chenghe Lin
Summary: This study investigates the diagnostic value of thyroglobulin (Tg) and anti-thyroglobulin antibody (anti-TgAb) combined with emission computed tomography (ECT) in the adjuvant diagnosis of differentiated thyroid carcinoma (DTC). The results show that the combination of Tg, anti-TgAb, and ECT has higher consistency and accuracy in DTC diagnosis, effectively improving the diagnostic accuracy and reducing the missed diagnosis rate.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Giovanna Rotondo Dottore, Marenza Leo, Roberta Ricciardi, Michelangelo Maestri, Ilaria Bucci, Marco Lucchi, Franca Melfi, Melania Guida, Anna De Rosa, Loredana Petrucci, Ilaria Ionni, Giulia Lanzolla, Francesca Nicoli, Michele Mantuano, Debora Ricci, Francesco Latrofa, Stefano Mariotti, Claudio Marcocci, Michele Marino
Summary: This study investigated the role of the thymus in thyroid autoimmunity and found that the prevalence of serum anti-thyroid autoantibodies significantly decreased in patients who underwent thymectomy, suggesting a potential role of the thymus in maintaining humoral thyroid autoimmunity.
EUROPEAN THYROID JOURNAL
(2021)
Review
Endocrinology & Metabolism
Timothy M. Ullmann, Maria Papaleontiou, Julie Ann Sosa
Summary: This review discusses the controversies and difficult decisions in the management of low-risk differentiated thyroid cancer (DTC) and provides recommendations. While overdiagnosis is a concern, the true incidence of DTC has also increased. Treatment options vary, and personalized and nuanced treatment decisions are necessary for clinicians and patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Clinical Neurology
Lianfeng Chen, Wenlin Wu, Yang Tian, Yiru Zeng, Chi Hou, Haixia Zhu, Kelu Zheng, Yani Zhang, Yuanyuan Gao, Bingwei Peng, Sida Yang, Xiuying Wang, Shuyao Ning, Yinting Liao, Haisheng Lin, Kaili Shi, Xiaojing Li, Wen-Xiong Chen
Summary: In pediatric anti-NMDAR encephalitis, high rates of ATA antibody positivity, thyroid function abnormalities, and NTIS are common. The treatment course can improve thyroid antibody and hormone abnormalities. Patients with ATA antibody positivity may exhibit different clinical characteristics.
FRONTIERS IN NEUROLOGY
(2021)
Review
Endocrinology & Metabolism
Tommaso Piticchio, Francesco Frasca, Pasqualino Malandrino, Pierpaolo Trimboli, Nunzia Carrubba, Andrea Tumminia, Federica Vinciguerra, Lucia Frittitta
Summary: This meta-analysis examines the effect of a gluten-free diet (GFD) on TgAb, TPOAb, TSH, FT4, and FT3 levels in patients with Hashimoto's thyroiditis (HT) and no symptoms or histology of celiac disease (CD). The results indicate that GFD can reduce antibody levels, decrease TSH levels, and increase FT4 levels in HT patients, but has no significant effect on FT3 levels. However, current evidence is not sufficient to recommend this dietary approach to all patients with a diagnosis of HT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Genetics & Heredity
Yingxin Fang, Tingting Liu, Huimin Hou, Zhihong Wang, Zhongyan Shan, Yanli Cao, Xiaochun Teng
Summary: Resistance to thyroid hormone beta (RTHb) is a rare hereditary disorder that is difficult to diagnose. Recent studies have suggested a connection between THRB mutations and human cancers. This study reports two cases of RTHb coexisting with papillary thyroid carcinoma (PTC), and follow-up results show no recurrence of cancer.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Nils Marechal, Banyuhay P. Serrano, Xinyan Zhang, Charles J. Weitz
Summary: Thyroid hormones play vital roles in metabolism, development, and growth, but the process of their formation is still poorly understood. By analyzing the cryo-EM structure of native bovine thyroglobulin, scientists have identified local structural rearrangements during the formation of nascent thyroid hormones, providing insights into the mechanisms underlying hormone formation and stabilization.
NATURE COMMUNICATIONS
(2022)
Review
Gastroenterology & Hepatology
Federica Gagliardi, Augusto Lauro, Domenico Tripodi, Maria Ida Amabile, Piergaspare Palumbo, Filippo Maria Di Matteo, Giorgio Palazzini, Flavio Forte, Stefano Frattaroli, Simone Khouzam, Ignazio R. Marino, Vito D'Andrea, Salvatore Sorrenti, Daniele Pironi
Summary: Mesenteric cysts are abdominal cystic lesions that are often asymptomatic and diagnosed incidentally. Symptomatic patients present with nonspecific gastrointestinal symptoms. Treatment options include surgery and interventional radiology.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Health Care Sciences & Services
Enke Baldini, Augusto Lauro, Domenico Tripodi, Daniele Pironi, Maria Ida Amabile, Iulia Catalina Ferent, Eleonora Lori, Federica Gagliardi, Maria Irene Bellini, Flavio Forte, Patrizia Pacini, Vito Cantisani, Vito D'Andrea, Salvatore Sorrenti, Salvatore Ulisse
Summary: Epidemiological studies have shown an association between thyroid diseases and extra-thyroidal malignancies, particularly breast cancer. Patients with autoimmune thyroiditis have an increased risk of breast cancer, although the risk is lower for those who are thyroid autoantibody-positive. The molecular links between thyroid autoimmunity and breast cancer remain uncertain.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Surgery
Giulio Illuminati, Priscilla Nardi, Daniele Fresilli, Salvatore Sorrenti, Augusto Lauro, Giulia Pizzardi, Massimo Ruggeri, Salvatore Ulisse, Vito Cantisani, Vito D'Andrea
Summary: This study evaluates the preliminary results of a fully ultrasound-assisted endovascular repair (EVAR) without iodine contrast administration. The results show that this method is safe, feasible, and reliable, eliminating the need for iodine contrast medium and reducing radiation exposure.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Enke Baldini, Dario Presutti, Pasqualino Favoriti, Simonetta Santini, Giuliana Papoff, Chiara Tuccilli, Raffaella Carletti, Cira Di Gioia, Eleonora Lori, Iulia Catalina Ferent, Federica Gagliardi, Antonio Catania, Daniele Pironi, Domenico Tripodi, Vito D'Andrea, Salvatore Sorrenti, Giovina Ruberti, Salvatore Ulisse
Summary: Increased expression of urokinase-type plasminogen activator (uPA) system is associated with aggressive traits of cancer. A specific uPA inhibitor, WX-340, showed reduced cell adhesion and invasiveness in vitro and in vivo. However, it may not have significant therapeutic effects on the growth of anaplastic thyroid carcinoma (ATC).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Rossella Tozzi, Davide Masi, Fiammetta Cipriani, Savina Contini, Elena Gangitano, Maria Elena Spoltore, Ilaria Barchetta, Sabrina Basciani, Mikiko Watanabe, Enke Baldini, Salvatore Ulisse, Carla Lubrano, Lucio Gnessi, Stefania Mariani
Summary: This study evaluated the relationship between SIRT1 and sclerostin with bone mass and quality, finding a negative correlation between SIRT1 and bone density, and a negative correlation between sclerostin and bone mass. The results suggest that blood measurement of SIRT1 and sclerostin, taking into account weight and adiposity, can provide a more accurate assessment of bone health.
Review
Biochemistry & Molecular Biology
Salvatore Ulisse, Enke Baldini, Daniele Pironi, Federica Gagliardi, Domenico Tripodi, Augusto Lauro, Sabino Carbotta, Danilo Tarroni, Matteo D'Armiento, Aldo Morrone, Flavio Forte, Flaminia Frattaroli, Severino Persechino, Teresa Odorisio, Vito D'Andrea, Eleonora Lori, Salvatore Sorrenti
Summary: There is evidence suggesting a relationship between thyroid diseases and melanoma, with hypothyroidism potentially promoting melanoma spread and thyroid hormones playing a protective role. Other hormonal factors in the hypothalamic-pituitary-thyroid (HPT) axis may also affect melanoma cell behavior. Further research is needed to understand the precise action of HPT hormones on melanoma cells, which could lead to improved and personalized clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Federica Gagliardi, Enke Baldini, Eleonora Lori, Silvia Cardarelli, Daniele Pironi, Augusto Lauro, Domenico Tripodi, Piergaspare Palumbo, Eleonora D'Armiento, Giuseppe Cavallaro, Andrea Polistena, Valerio D'Orazi, Simone Sibio, Poupak Fallahi, Alessandro Antonelli, Vito D'Andrea, Salvatore Ulisse, Salvatore Sorrenti
Summary: Benign and malignant thyroid diseases are linked to the occurrence of extrathyroidal malignancies, including colorectal cancers. Understanding the relationship between these diseases can provide insights into their etiology and/or progression, as well as potential shared genetic and environmental factors. Exploring the underlying molecular mechanisms can lead to improved clinical management and increased surveillance for patients with thyroid diseases at a higher risk of developing extrathyroidal malignancies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Vincenzo Dolcetti, Eleonora Lori, Daniele Fresilli, Giovanni Del Gaudio, Chiara Di Bella, Patrizia Pacini, Vito D'Andrea, Fabrizio Maria Frattaroli, Giulia Giordana Vallone, Piero Liberatore, Daniele Pironi, Gian Luigi Canu, Pietro Giorgio Calo, Vito Cantisani, Salvatore Sorrenti
Summary: To reduce bleeding-related morbidity in thyroid surgery, new techniques and devices for controlling bleeding have been introduced. The study aimed to describe the ultrasound appearance of topical hemostatics in patients undergoing thyroidectomy. The study evaluated the advantages and disadvantages of different hemostatic agents, including oxidized regenerated cellulose and fibrin glue.
Editorial Material
Oncology
Salvatore Sorrenti, Pietro Giorgio Calo
Article
Nutrition & Dietetics
Vincenzo Spina, Enke Baldini, Silvia Cardarelli, Cosimo Oliva, Stefano Venarubea, Franca Faraoni, Giovanni Pastore, Rachele Tittoni, Angela Musella, Antonia Squarcella, Eleonora Lori, Elisabetta Renzi, Roberta Feroci, Flavia Mastrodonato, Fabiola Ciferri, Camilla Virili, Marco Centanni, Cristina Fabiani, Rocco Rago, Michele Carlo Schiavi, Pierluigi Palazzetti, Eleonora D'Armiento, Vito Cantisani, Salvatore Sorrenti, Salvatore Ulisse
Summary: Adequate iodine intake is crucial in pregnancy, and pregnant women and their fetuses are still exposed to iodine deficiency. The consumption of iodine-containing supplements should be recommended in pregnancy.
Article
Medicine, General & Internal
Angela Gurrado, Alessandro Pasculli, Nicola Avenia, Rocco Bellantone, Marco Boniardi, Isabella Merante Boschin, Pietro Giorgio Calo, Michele Camandona, Giuseppe Cavallaro, Fabio Cianchi, Giovanni Conzo, Vito D'Andrea, Carmela De Crea, Loredana De Pasquale, Paolo Del Rio, Giovanna Di Meo, Gianlorenzo Dionigi, Chiara Dobrinja, Giovanni Docimo, Fausto Fama, Attilio Galimberti, Laura Giacomelli, Giuseppa Graceffa, Maurizio Iacobone, Nadia Innaro, Celestino Pio Lombardi, Gabriele Materazzi, Fabio Medas, Barbara Mullineris, Luigi Oragano, Nicola Palestini, Giuliano Perigli, Angela Pezzolla, Francesco Paolo Prete, Marco Raffaelli, Giuseppina Renzulli, Lodovico Rosato, Gregorio Scerrino, Lucia Ilaria Sgaramella, Salvatore Sorrenti, Carlotta Testini, Massimiliano Veroux, Guido Gasparri, Mario Testini
Summary: This multicenter study aimed to describe the clinical characteristics and differentiate parathyroid cancer (PC) from atypical parathyroid tumour (APT). The study found significant differences between PC and APT in terms of bone involvement, abdominal and neurological symptoms, and ultrasound diameter.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Noemi Zorzetti, Augusto Lauro, Manuela Cuoghi, Marco La Gatta, Ignazio R. Marino, Salvatore Sorrenti, Vito DAndrea, Andrea Mingoli, Giuseppe Giovanni Navarra
Summary: This article introduces the use of ICG-FA in evaluating patients with acute appendicitis undergoing laparoscopic appendectomy. This new method provides intraoperative information on tissue and organ perfusion, guiding surgical decisions and techniques.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Gian Luigi Canu, Federico Cappellacci, Ahmed Abdallah, Islam Elzahaby, David Figueroa-Bohorquez, Eleonora Lori, Julie A. Miller, Sergio Zuniga Pavia, Pilar Pinillos, Atcharaporn Pongtippan, Saleh Saleh Saleh, Salvatore Sorrenti, Chutintorn Sriphrapradang, Pietro Giorgio Calo, Fabio Medas
Summary: This study evaluated the management of indeterminate thyroid nodules across different regions, finding that the Asian region leans towards active surveillance while Eastern regions have a more aggressive approach. Current clinical practice diverges from guidelines, particularly regarding fine-needle aspiration cytology indications. The study highlights the need for homogenous guidelines and new tools to assess the actual risk of malignancy in patients with indeterminate thyroid nodules.