Article
Oncology
Sarah M. Bernhardt, Pallave Dasari, Danielle J. Glynn, Amanda R. Townsend, Timothy J. Price, Wendy V. Ingman
Summary: This study showed that estrogen and progesterone have similar effects on mRNA and protein biomarker expression in hormone-responsive breast cancer xenografts, but there may be differences between cell lines. Further research is needed to investigate the concordance between protein and mRNA biomarkers in premenopausal breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Mana Miyamoto, Kenichi Shibuya
Summary: This study aimed to examine potential variations in nutritional intake among female athletes during their menstrual cycle. The findings indicated that there were no notable disparities in nutritional intake across the three phases of the menstrual cycle, suggesting that female athletes may experience comparatively smaller variations in nutrient intake related to their menstrual cycle.
Article
Oncology
Daniela Nahmias-Blank, Ofra Maimon, Amichay Meirovitz, Kim Sheva, Tamar Peretz-Yablonski, Michael Elkin
Summary: Postmenopausal, obese women have a higher risk of developing estrogen receptor-positive (ER+) breast tumors, which are resistant to therapies. The relationship between obesity and breast cancer differs in pre-menopausal and post-menopausal women. Elucidation of the molecular mechanisms behind obesity-related breast tumors is critical for disease prevention and treatment. Understanding these mechanisms could potentially prevent and intervene in the promotion of breast cancer associated with excess adiposity.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Behavioral Sciences
Zahira Z. Cohen, Neta Gotlieb, Offer Erez, Arnon Wiznitzer, Oded Arbel, Devorah Matas, Lee Koren, Avishai Henik
Summary: The menstrual cycle affects cognition through fluctuations in estradiol and progesterone. This study examined the performance of naturally cycling women and women using oral contraceptives using the ANT-I test. The results showed that naturally cycling women had different performance in the follicular and luteal phases, while women using oral contraceptives performed consistently at both time points.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Endocrinology & Metabolism
Manon Dubol, C. Neill Epperson, Julia Sacher, Belinda Pletzer, Birgit Derntl, Rupert Lanzenberger, Inger Sundstrom-Poromaa, Erika Comasco
Summary: Increasing evidence suggests that ovarian hormones influence the brain structure, chemistry, and function of women in their reproductive age, potentially shaping their behavior and mental health. Specifically, these hormones fluctuations appear to have modulatory effects on the reactivity and structure of cortico-limbic brain regions.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Katja M. Schmalenberger, Hafsah A. Tauseef, Jordan C. Barone, Sarah A. Owens, Lynne Lieberman, Marc N. Jarczok, Susan S. Girdler, Jeff Kiesner, Beate Ditzen, Tory A. Eisenlohr-Moul
Summary: Despite decades of research, there is still confusion in the methodology of studying the physiological and psychological effects of the menstrual cycle. A set of guidelines and tools offered in this paper aims to improve the meaningfulness and replicability of study results.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Oncology
Yi Jiang, Qinli Xie, Rong Chen
Summary: Hormone replacement therapy is associated with increased risk of breast cancer, especially for slim postmenopausal women.
CLINICAL BREAST CANCER
(2022)
Review
Endocrinology & Metabolism
Qianying Zuo, Shoham Band, Mrinali Kesavadas, Zeynep Madak Erdogan
Summary: Obesity is a potential risk factor for various cancers, including hormone-dependent breast cancer in postmenopausal women. This review summarizes recent research on the impact of obesity on postmenopausal women's health and discusses several proposed mechanisms for increasing the risk of breast carcinogenesis.
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Physiology
Beatriz Rael, Laura Barba-Moreno, Nuria Romero-Parra, Victor M. Alfaro-Magallanes, Eliane A. Castro, Rocio Cupeiro, Ana B. Peinado
Summary: The study found that postmenopausal women had lower peak heart rate and VO2 values compared to eumenorrheic females in maximal aerobic exercise testing, while there were no differences in respiratory variables at peak values. Monophasic oral contraceptive pills did not impact the cardiorespiratory response in endurance-trained females.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Erin E. Maher, Ashley M. Strzelecki, Jessica J. Weafer, Cassandra D. Gipson
Summary: Clinically, women may have a higher susceptibility to certain aspects of substance use disorders, and this may be influenced by the steroid hormones 17 beta-estradiol (E2) and progesterone (Pg). This review examines the effects of cycling ovarian hormones on nicotine, cocaine, and opioid-related behaviors, and also explores the potential influence of synthetic steroid hormone use. It further investigates the interactions of E2 and Pg in brain reward pathways and their impact on drug-related behaviors, emphasizing the importance of studying women-specific factors in addiction research.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Ludmila Dos Anjos, Fabio Rodrigues, Sofia Scataglini, Rafael Reimann Bapista, Paula Lobo da Costa, Marcus Fraga Vieira
Summary: The purpose of this study was to investigate how generalized fatigue and hormonal changes throughout the menstrual cycle affect trunk variability and local dynamic stability during gait. The results showed that after the incremental test, variability increased and local dynamic stability decreased. Women showed a faster recovery rate compared to men, but the luteal phase had significantly lower local dynamic stability than the follicular phase.
Article
Oncology
Chuner Jiang, Peng Wu, Xiangming He, Jianfen Ni, Xiaowen Ding, Xiaohong Xu, Fangzheng Wang, Dehong Zou
Summary: This study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. The results showed that decreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer.
FRONTIERS IN ONCOLOGY
(2022)