Review
Oncology
Jin Wu, Guanting Lu, Xinjiang Wang
Summary: MDM4, originally named MDMX, is an oncogene that plays critical roles in promoting cancer cell growth and inhibiting apoptosis by blocking the p53 pathway. Different splicing isoforms of MDM4 show potential therapeutic value in cancer treatment, making them attractive targets for therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xu Dong, Jiabao Xing, Qingchun Liu, Mao Ye, Zhen Zhou, Yantao Li, Rongqin Huang, Zhenhui Li, Qinghua Nie
Summary: In this study, a circRNA-miRNA-mRNA interaction network was identified in chicken primary myoblasts' myogenesis. The circPLXNA2-gga-miR-12207-5P-MDM4 axis was found to play a critical role in regulating myogenesis by inhibiting apoptosis and promoting cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Peng Huang, Yibing Zhang, Fengjun Wang, Meng Qin, Jiulong Ma, Jiahua Ji, Dexian Wei, Liqun Ren
Summary: This study aimed to investigate the effect and mechanism of miR-494-3p on THP-induced cardiomyocytes. The results showed that miR-494-3p could reduce cell viability, increase oxidative damage, and promote cell apoptosis. It also inhibited the expression of MDM4, promoted the activation of p53, and promoted the expression of apoptosis-related proteins.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Article
Oncology
Javier Octavio Mejia-Hernandez, Dinesh Raghu, Franco Caramia, Nicholas Clemons, Kenji Fujihara, Thomas Riseborough, Amina Teunisse, Aart G. Jochemsen, Lars Abrahmsen, Giovanni Blandino, Andrea Russo, Cristina Gamell, Stephen B. Fox, Catherine Mitchell, Elena A. Takano, David Byrne, Panimaya Jeffreena Miranda, Reem Saleh, Heather Thorne, Shahneen Sandhu, Scott G. Williams, Simon P. Keam, Ygal Haupt, Sue Haupt
Summary: Prostate cancer is a common male cancer, and high levels of MDM4 are associated with an increased risk of prostate cancer. Inhibiting MDM4 may serve as a novel treatment approach for prostate cancer.
Article
Medicine, Research & Experimental
Qianru Mei, Zhenhua Yang, Zhengkai Xiang, He Zuo, Zijing Zhou, Xiaochuan Dong, Ludan Zhang, Wenhui Song, Yi Wang, Qinghua Hu, Yong Zhou, Jing Qu
Summary: This study evaluated the efficacy of XI-011, a small molecular inhibitor of MDM4, for treating lung fibrosis. XI-011 significantly reduced MDM4 expression and increased the expression of p53. XI-011 treatment resulted in the resolution of lung fibrosis in mice with no notable impact on normal fibroblast death or the morphology of healthy lungs. Therefore, XI-011 might be a promising therapeutic drug candidate for treating pulmonary fibrosis.
Article
Cell Biology
Rossella Luca, Maria Rita Assenza, Fabio Maiullari, Luisa Pieroni, Silvia Maiullari, Giulia Federici, Federica Marini, Roberto Rizzi, Andrea Urbani, Silvia Soddu, Fabiola Moretti
Summary: MDM4 impairs the metastatic process of EOC by inhibiting mTOR activity, reducing cell migration. High levels of MDM4 expression are associated with significantly increased 15-year survival rate and negative impact on the efficacy of mTOR inhibitors.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Agne Bartnykaite, Aiste Savukaityte, Rasa Ugenskiene, Monika Dauksaite, Erika Korobeinikova, Jurgita Gudaitiene, Elona Juozaityte
Summary: The study found specific SNPs in MDM2 and MDM4 are closely associated with estrogen receptor status, HER2 status, and estrogen/progesterone receptor status in breast cancer, providing potential genetic markers for disease assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Youqin Xu, Wancheng Chen, Jing Liang, Xiaoqi Zeng, Kaiyuan Ji, Jianlong Zhou, Shijun Liao, Jiexian Wu, Kongyang Xing, Zilong He, Yang Yang, Qianzhen Liu, Pingyi Zhu, Yuchang Liu, Li Li, Minfeng Liu, Wenxiao Chen, Wenhua Huang
Summary: In this study, it was shown that GOLPH3L plays a crucial role in breast cancer tumorigenesis. Knockdown of GOLPH3L suppressed tumorigenic activities, while overexpression promoted aggressive behavior. The miRNA-GOLPH3L-SERPINE1 pathway was identified as a potential therapeutic target for human breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Hui Yang, Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Linping Xu, Chunhua Song
Summary: The study revealed an association between MIR2052HG gene polymorphism and breast cancer susceptibility, particularly showing that the MIR2052HG rs34841297 A/- genotype may affect the proliferation, invasion, and migration of breast cancer cells by modulating interactions with miR-4456.
Article
Chemistry, Medicinal
Shiyan Zhang, Ziqin Yan, Yafang Li, Yang Gong, Xilin Lyu, Jianfeng Lou, Daizhou Zhang, Xiangjing Meng, Yujun Zhao
Summary: A new small-molecule inhibitor, 31 (YL93), was designed and synthesized to target both MDM2 and MDM4, resulting in stronger antitumor activities in wild-type p53 and MDM4-overexpressing cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Maral Jamshidi, Rainer Fagerholm, Taru A. Muranen, Sippy Kaur, Swapnil Potdar, Sofia Khan, Eliisa Netti, John-Patrick Mpindi, Bhagwan Yadav, Johanna Kiiski, Kristiina Aittomaki, Paivi Heikkila, Jani Saarela, Ralf Butzow, Carl Blomqvist, Heli Nevanlinna
Summary: A comprehensive study on the role of the miR-30 family in breast cancer revealed that high miR-30d expression is associated with improved survival in aggressive tumor phenotypes. Drug sensitivity analysis showed that ectopic expression of miR-30 family members sensitized breast cancer cell lines to treatment. Pathway analysis suggested that the miR-30 family may inhibit pathways contributing to EMT and metastasis in breast cancer.
Article
Health Care Sciences & Services
Ling Pan, Wenya Liu, Hao Zhao, Bin Chen, Xuandi Yue
Summary: This study found that miR-191-5p is highly expressed in breast cancer cells and promotes epithelial-mesenchymal transition and malignant progression of breast cancer through targeting KLF6. Moreover, significantly elevated levels of miR-191-5p were observed in the blood exosomes of breast cancer patients, suggesting that miR-191-5p and KLF6 could be potential biomarkers for breast cancer.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Chemistry, Medicinal
Shiyan Zhang, Jianfeng Lou, Yafang Li, Feilong Zhou, Ziqin Yan, Xilin Lyu, Yujun Zhao
Summary: This study summarized inhibitors of MDM4/p53 interactions, including small molecules and peptide-based compounds. Recent research suggests that concurrent inhibition of MDM4 and MDM2 might be more beneficial than only targeting MDM2, providing a reference for further development of MDM4 inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Margarida Espadinha, Elizabeth A. Lopes, Vanda Marques, Joana D. Amaral, Daniel J. V. A. dos Santos, Mattia Mori, Simona Daniele, Rebecca Piccarducci, Elisa Zappelli, Claudia Martini, Cecilia M. P. Rodrigues, Maria M. M. Santos
Summary: MDM2 and MDM4 are important negative regulators of p53, and inhibiting their protein-protein interactions can reactivate the tumor suppressor function of p53. Spiropyrazoline oxindole compounds have been developed as potential inhibitors, with compound 3b showing promise as an anti-osteosarcoma agent. Compounds 2a, 2q, and 3f also have potential as dual MDM2/4 inhibitors and p53 activators.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wanxue Lv, Boqiang Fu, Manli Li, Yu Kang, Shouli Bai, Chao Lu
Summary: A simple, sensitive, and repeatable D2O-single cell Raman spectroscopy method was developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC50 values obtained from A549 cells incubated with cisplatin and taxol are comparable with the results of CCK-8 and ATP luminescent cell viability assays.
CHEMICAL COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Jintao Fu, Ting Liu, Xiaoqian Feng, Yixian Zhou, Minglong Chen, Wenhao Wang, Yiting Zhao, Chao Lu, Guilan Quan, Jianfeng Cai, Xin Pan, Chuanbin Wu
Summary: Engineered black phosphorus (BP) nanosheets with epsilon-poly-l-lysine (ε-PL) have been developed to enhance antibacterial activity and achieve in situ hyperthermia under near-infrared irradiation. The BP@ε-PL complex can effectively disinfect Methicillin-resistant Staphylococcus aureus (MRSA) within 15 minutes in vitro and achieve a 99.4% antibacterial rate in an MRSA skin infection model in vivo, with minimal toxicity.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yang Liu, Jiaojiao Zheng, Wencai Liu, Zhiqin Yuan, Chao Lu
Summary: This review focuses on the recent advances and applications of steady-state and dynamic bioanalysis based on carbon quantum dots (CQDs) as luminescent probes. The synthesis and luminescence mechanism of CQDs are first introduced, followed by the discussion of sensing principles and tactics in CQD-based luminescent bioanalysis. Steady-state bioanalysis systems and dynamic bioanalysis platforms are discussed, and challenges and future trends are also addressed.
Article
Chemistry, Physical
Jintao Fu, Yixian Zhou, Ting Liu, Wenhao Wang, Yiting Zhao, Ying Sun, Yiming Zhang, Wenxuan Qin, Zhongwei Chen, Chao Lu, Guilan Quan, Chuanbin Wu, Xin Pan
Summary: The research team constructed antibacterial nanoreactors that achieved efficient sterilization by overcoming the limitations of pH and H2O2, and combined photothermal therapy and photodynamic therapy to enhance bactericidal efficiency and broaden the antibacterial spectrum, alleviating antibiotic resistance issues.
Article
Engineering, Environmental
Xiaoqian Feng, Dongyi Xian, Jintao Fu, Rui Luo, Wenhao Wang, Yuwei Zheng, Qing He, Zhan Ouyang, Shaobin Fang, Wancong Zhang, Daojun Liu, Shijie Tang, Guilan Quan, Jianfeng Cai, Chuanbin Wu, Chao Lu, Xin Pan
Summary: A vanadium-based MXene composite nanosheet, 4 K10@V2C, was constructed for disease treatment. It integrates membranolytic, photothermal, and photocatalytic abilities, demonstrating efficient bacteria-killing of focal infections. The nanosheets achieved synergistic membranolytic-photothermal effects against biofilm bacteria and showed impressive in vitro antimicrobial activity. The transdermal delivery of the nanosheets eradicated skin infections with high efficacy and minimal toxicity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Maochao Zheng, Xiaolei Wu, Chao Lu, Wancong Zhang, Shijie Tang, Ying Luo, Daojun Liu
Summary: The development of alternative antimicrobial therapeutics is needed due to the emergence of antibiotic resistance in bacterial pathogens. Polypept(o)ide-based bactericides, which mimic antimicrobial host defense peptides, have shown promise in the treatment of antibiotic-resistant and recurring infections. This review summarizes recent advances in membrane-active polypept(o)ide-based bactericides, focusing on their ability to disrupt bacterial cell walls/membranes and combat acquired antibiotic resistance and biofilm formation.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jingwen Deng, Dongyi Xian, Xiaopeng Cai, Shaoxia Liao, Siqin Lei, Fengyan Han, Yandong An, Qing He, Guilan Quan, Chuanbin Wu, Tingting Peng, Chao Lu, Honghe Zhang
Summary: A surface-engineered vanadium carbide MXene nanoenzyme (MXenzyme) with amino functionalization and gallium doping (Ga/V2C-NH2) is developed to inhibit the development of colitis-associated colorectal cancer and provide an efficient anticancer therapy. MXenzymes have shown great potential to decrease excessive reactive oxygen species and inhibit proinflammatory cytokines, resulting in good anti-inflammatory effects on dextran sulfate sodium-induced acute colitis. Moreover, gallium-doped MXene with an amino-functionalized surface can mediate improved MXene-tumor interactions and inhibitory effects on cell proliferation, achieving precise and efficient chemo-photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Maochao Zheng, Qianqian Yang, Chao Lu, Xiaolei Wu, Wei Yan, Daojun Liu
Summary: In this article, promising opportunities in the field of aggregate science for the discovery of novel disease phototheranostics are highlighted. By employing aggregology and the Jablonski energy level diagram, photosensitizer aggregates with adjustable photophysical properties can be formed, leading to customizable diagnosis and treatment modalities. The review focuses on recent advances in the formation of nanostructured organic photosensitizer aggregates, their photophysical processes, and their applications in disease phototheranostics such as fluorescence imaging, photothermal therapy, photoacoustic imaging, and photodynamic therapy. This comprehensive summary is expected to provide guidance for the construction of nanostructured organic photosensitizer aggregates, establishment of aggregation-photophysical property relationships, and development of novel disease phototheranostic nanomedicines.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Multidisciplinary
Dan Yang, Minglong Chen, Ying Sun, Chaonan Shi, Wenhao Wang, Wanchen Zhao, Ting Wen, Ting Liu, Jintao Fu, Chao Lu, Chuanbin Wu, Guilan Quan, Xin Pan
Summary: Despite obstacles in vaccination, a new antitumor vaccine patch called TCV-DMNs has been developed. It effectively suppresses melanoma and promotes regression of established malignancies. This is achieved through the transdermal delivery of GM-CSF and Tat-beclin 1, which recruit dendritic cells and enhance their antigen presentation capabilities through autophagy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Miao Pan, Chao Lu, Wancong Zhang, Huan Huang, Xingyu Shi, Shijie Tang, Daojun Liu
Summary: Anticancer peptides and polymers can interact with tumor cells to overcome multidrug resistance. In this study, PLO-b-PLF block copolypeptides were prepared and self-assembled into polymeric micelles. The cationic micelles interacted with cancer cells via electrostatic interactions and killed them via membrane lysis. To reduce cytotoxicity, anionic PLO(DCA)-b-PLF was designed to recover anticancer activity in the acidic tumor microenvironment. These PLO-based polypeptides have potential applications in drug-free tumor treatment.
Article
Pharmacology & Pharmacy
Ling Jiang, Huan Huang, Xingyu Shi, Jian Wu, Juexian Ye, Qian Xu, Shaobin Fang, Chuanbin Wu, Rui Luo, Chao Lu, Daojun Liu
Summary: With the increasing awareness of food safety, the use of biocompatible antimicrobials to replace toxic pesticides has become a trend. This study introduces a biocontrol microneedle (BMN) system to expand the application of the food-grade preservative e-PL in fruit preservatives. The e-PL-based microneedle patch has good mechanical properties and high drug loading capacity, allowing for enhanced antimicrobial activity in citrus fruit pericarps and reducing the incidence of invasive fungal infections.
Article
Pharmacology & Pharmacy
Minmin Zhang, Beibei Yang, Xuanyu Luan, Ling Jiang, Chao Lu, Chuanbin Wu, Xin Pan, Tingting Peng
Summary: Dissolving microneedles (MNs) have been developed to improve drug-loading and transdermal delivery efficiency, combining the advantages of injection and transdermal preparations. This study systematically investigated the effects of mold production technologies, micromolding technologies, and formulation parameters on the quality of gas-propelled MNs. The optimized gas-propelled MNs achieved higher drug loading and cumulative transdermal permeability compared to passive MNs. These findings provide detailed guidance for preparing high-quality MNs with enhanced productivity and delivery efficiency.
Article
Nanoscience & Nanotechnology
Xinyi Gao, Fapeng Zhang, Yao Huang, Wanshan Hu, Yangyan Chen, Ling Jiang, Xin Pan, Chuanbin Wu, Chao Lu, Tingting Peng
Summary: This study developed a microneedle-mediated open-loop therapy for the management of psoriasis-diabetes comorbidity. By inhibiting the NF-kappa B signaling pathway, this therapy disrupts the crosstalk between inflammation and insulin resistance, resulting in dual anti-inflammatory and antihyperglycemic properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Ling Jiang, Jiaying Chi, Jiahui Wang, Shaobin Fang, Tingting Peng, Guilan Quan, Daojun Liu, Zhongjie Huang, Chao Lu
Summary: An amphiphilic copolymer, PCPZL, was developed to encapsulate SPIO nanocrystals effectively, forming highly loaded SPIO nanoclusters. PCPZL demonstrated enhanced stability and magnetic properties, making it a promising MRI contrast agent for diagnosing liver diseases and cancers.
Article
Materials Science, Multidisciplinary
Meihong Zhang, Yixian Zhou, Biyuan Wu, Chao Lu, Guilan Quan, Zhengwei Huang, Chuanbin Wu, Xin Pan
Summary: Photodynamic therapy selectively kills tumor cells using reactive oxygen species (ROS), but traditional methods lack sufficient ROS. Metal organic frameworks (MOFs) can convert hydrogen peroxide in tumor tissues into ROS and improve efficiency through their unique pores. Furthermore, MOFs can co-deliver photosensitizers and chemotherapeutic drugs for synergistic tumor cell killing.
MATERIALS ADVANCES
(2023)