Article
Biotechnology & Applied Microbiology
Siqi Geng, Qiang Feng, Chujie Wang, Ying Li, Jiaying Qin, Mingsheng Hou, Jiedong Zhou, Xiaoyu Pan, Fei Xu, Baoru Fang, Ke Wang, Zhangsen Yu
Summary: Photothermal therapy (PTT) is a promising clinical application for cancer treatment, but it is difficult to eliminate tumor cells completely, leading to recurrence and metastasis. Chemo-photothermal synergistic therapy can overcome these limitations by killing residual tumor cells through chemotherapy. In this study, polydopamine nanoparticles (PDA) were used as a carrier for the chemotherapeutic drug doxorubicin (DOX) to construct a versatile nanoplatform for chemo-photothermal synergistic therapy against breast cancer and to attenuate DOX-induced cardiotoxicity (DIC). The PDA(DOX) nanoparticles showed excellent photothermal properties for tumor ablation and simultaneously alleviated DIC due to PDA's antioxidant enzyme activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gabriel Mendez-Valdes, Francisca Gomez-Hevia, Maria Chiara Bragato, Jose Lillo-Moya, Catalina Rojas-Sole, Luciano Saso, Ramon Rodrigo
Summary: Breast cancer is the most common malignant neoplastic disease in women, and its treatment depends on patient and tumor characteristics. The overexpression of the HER2 receptor, found in 15-25% of tumors, is associated with aggressive behavior and poor prognosis. Trastuzumab, a monoclonal antibody used as targeted therapy against HER2 receptor overexpression, has a major concern of cardiotoxicity. This review aims to explore the use of antioxidants as adjuvant therapy to prevent trastuzumab-induced cardiac toxicity and improve its safety profile.
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi
Summary: ROS play a crucial role in cellular processes, with Keap1-Nrf2 pathway acting as a master antioxidant mechanism. While activation of Nrf2 benefits cells in early stages by reducing ROS levels, hyperactivation can support the survival of healthy and cancer cells against oxidative stress and treatments. Understanding the dual role of Nrf2 in cancer cells can be important in cancer treatment strategies.
Article
Oncology
Parth Sharma, Josh Thomas Georgy, Anand George Andrews, Ajoy Oommen John, Anjana Joel, Raju Titus Chacko, Prasanna Samuel Premkumar, Ashish Singh
Summary: This study investigated the prevalence of chemotherapy-related anemia and the associated risk factors in Indian breast cancer patients receiving dose-dense chemotherapy. The results showed that anemia is a common complication of dose-dense chemotherapy, leading to treatment delay and increased cost. Low-grade tumor, grade 3 or 4 thrombocytopenia, and grade 2 or higher anemia after two cycles of chemotherapy were identified as risk factors for blood transfusions during treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Biochemistry & Molecular Biology
Lidija Milkovic, Ana Cipak Gasparovic
Summary: Breast cancer remains a leading cause of female mortality, with aquaporins AQP3 and AQP5 playing significant roles in its development. Researchers are exploring the potential of targeting these aquaporins for new therapies in breast cancer treatment.
Review
Biochemistry & Molecular Biology
Jing Zhang, Doug W. Chan, Shiaw-Yih Lin
Summary: Proliferating cells depend on DNA replication for accurate genome duplication. Cancer cells, including breast cancer cells, experience increased replication stress (RS) due to uncontrolled oncogenic activation, loss of key tumor suppressors, and defects in DNA repair machinery. Targeting RS in breast cancer shows promising efficacy in preclinical and early clinical trials, but the challenge lies in balancing drug toxicity and clinical efficacy, as well as the need for biomarkers to guide patient selection.
Article
Oncology
Jiatong Lu, Shaoyu Guan, Jiajun Luo, Jingwen Yuan, Junfeng Yan, Chen Yang, Qiang Tong
Summary: The relationship between oxidative stress and treatment response in gastric cancer patients undergoing neoadjuvant chemotherapy was investigated in this study. Blood samples were collected from 108 patients and 108 healthy subjects. The results showed a decrease in antioxidant index and an increase in peroxide index in the patients compared to the normal group. However, after chemotherapy, the antioxidant index increased and the peroxide index decreased. Furthermore, an increased antioxidant index was associated with good treatment responsiveness.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Xavier Pivot
Summary: The study confirms the efficacy of pembrolizumab combined with chemotherapy in prolonging overall survival of patients with advanced triple-negative breast cancer, providing a breakthrough therapeutic treatment for this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Supriya Bevinakoppamath, Adel Mohammed Saleh Ahmed, Shobha Chikkavaddaraguddi Ramachandra, Prashant Vishwanath, Akila Prashant
Summary: Obesity is a significant risk factor for various cancers, including breast cancer, due to the increased levels of inflammatory cytokines driving pro-proliferative pathways. The association of obesity with breast cancer is mainly attributed to elevated estrogen levels and oxidative stress caused by chronic low-grade inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jen-Yang Tang, Jun-Ping Shiau, Ming-Feng Hou, Chia-Hung Yen, Fu Ou-Yang, Chung-Yi Chen, Hsueh-Wei Chang
Summary: Gin A, a compound isolated from ginger, has been found to inhibit proliferation and induce senescence of breast cancer cells through oxidative stress. It decreases cellular ATP content and cell viability, and delays the G2/M response in breast cancer cells. Additionally, Gin A induces oxidative stress and senescence responses by increasing reactive oxygen species, mitochondrial superoxide, and beta-galactosidase activity, and upregulates senescence-associated gene expressions. Gin A also induces DNA damage responses. These findings suggest the potential anticancer effects of Gin A on breast cancer cells.
Article
Nutrition & Dietetics
Luiza Kuhnen Reitz, Jaqueline Schroeder, Giana Zarbato Longo, Brunna Cristina Bremer Boaventura, Patricia Faria Di Pietro
Summary: The study found that intake of antioxidants may help reduce oxidative stress in women undergoing adjuvant treatment for breast cancer. Increasing dietary antioxidant capacity can lower oxidative stress levels and mitigate adverse changes in oxidation and antioxidant biomarkers.
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Chia-Hung Yen, Ming-Feng Hou, Yuan-Bin Cheng, Chih-Wen Shu, Hsueh-Wei Chang
Summary: The study demonstrates that PHA can induce autophagy in breast cancer cells, and autophagy inhibitors can enhance the cytotoxic effects of PHA. Furthermore, PHA increases ROS levels, while ROS scavenger NAC decreases PHA-induced autophagy activity. Autophagy inhibitors also enhance PHA-induced apoptosis, while NAC blocks apoptosis. This suggests that autophagy induced by PHA plays an antioxidant and anti-apoptotic role in breast cancer cells.
Article
Chemistry, Multidisciplinary
Mengjiao Zhou, Minjian Yuan, Yilan Jin, Qianqian Zhou, Yuting Yu, Jianan Li, Xing Dai, Xiaohua Zheng, Haijun Yu, Weiqi Wang
Summary: Ferroptosis, characterized by iron-dependent lipid peroxidation, plays a critical role in tumor regression. This study developed a self-assembled vitamin B2-ferric nanocomplex to regulate ferroptosis. The nanocomplex effectively delivered therapeutic agents to tumor sites and cancer cells, and synergistically promoted ferroptosis through the production of reactive oxygen species. Additionally, the use of metformin further disrupted the antioxidant system and enhanced the ferroptotic effect. This novel strategy showed promising antitumor efficacy with minimal adverse effects, providing a potential treatment option for breast carcinoma.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ran Ding, Qiwei Liu, Jing Yu, Yongkang Wang, Honglei Gao, Hongxing Kan, Yinfeng Yang
Summary: This study aimed to identify breast cancer (BC) subtype clusters and crucial gene classifier prognostic signatures by integrating genomic analysis with the tumor immune microenvironment (TME). The results showed that TCGA-BC samples could be divided into three subtype clusters, with S2 having a poorer prognosis and S1 and S3 having better prognoses. Three key pathways and 10 crucial prognostic-related gene signatures were screened. Single-cell analysis revealed that S1 samples showed the most types of immune cells, S2 samples were more sensitive to tumor treatment drugs and enriched with more neutrophils, while more multilymphoid progenitor cells were involved in subtype cluster S3. The findings provide a basis for the clinical precision treatment of BC.
Article
Oncology
Mohd Fazirul Mustafa, Suhainizam Muhamad Saliluddin, Sharida Fakurazi, Nur Maya Sabrina Tizen Laim, Suria Hayati Md Pauzi, Nik Hasimah Nik Yahya, Navarasi S. Raja Gopal, Maizaton Atmadini Abdullah, Sandra Maniam
Summary: This study measured autophagy, mitophagy, oxidative stress, and apoptosis levels in invasive breast carcinoma tissues using immunohistochemistry. Positive staining scores of Beclin-1 and Parkin were significantly higher in tumor tissues compared to other markers. Positive associations were also observed between BNIP-3 and Beclin-1, as well as LC-3 and cleaved caspase-3 immunostaining. The findings suggest potential new cancer biomarkers and the application of anti-autophagy therapies for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Emanuele Gustani Gustani-Buss, Carlos E. Buss, Luciane R. Cavalli, Carolina Panis, Felipe F. Tuon, Joao P. Telles, Franciele A. C. Follador, Guilherme W. Wendt, Leia C. Lucio, Lirane E. D. Ferreto, Isabela M. de Oliveira, Emerson Carraro, Lualis E. David, Andrea N. C. Simao, Angelica B. W. Boldt, Maria Luiza Petzl-Erler, Wilson A. Silva, David L. A. Figueiredo
Summary: This study evaluated the prediction factors of COVID-19 mortality in the Brazilian state of Parana. Male gender and age over 35 were associated with increased mortality in different levels of clinical severity. Dyspnea, as well as neurological disorders, neoplastic diseases, and kidney diseases, were linked to higher mortality rates.
Article
Oncology
Janaina Carla da Silva, Thalita Basso Scandolara, Rodrigo Kern, Hellen dos Santos Jaques, Jessica Malanowski, Fernanda Mara Alves, Daniel Rech, Guilherme Ferreira Silveira, Carolina Panis
Summary: This study examines the immunological changes induced by pesticide exposure in breast cancer patients and finds that occupational exposure to pesticides alters the molecular behavior of the disease, which should be considered in risk assessment for breast cancer patients.
Article
Medicine, Research & Experimental
Marcelo Marcos Opolski, Vitor Teixeira Maito, Aedra Carla Bufalo Kawassaki, Janaina Carla da Silva, Rodrigo Kern, Daniel Rech, Stefania Tagliari de Oliveira, Pamela Lonardoni Micheletti, Carolina Panis, Sabrina Grassiolli
Summary: This study evaluated the levels of TNF-alpha in the saliva and plasma of breast cancer and benign breast disease patients, finding higher levels in saliva than in plasma. However, these levels did not correlate with tumor features, indicating that TNF-alpha is not a useful salivary marker for breast cancer patients.
PRECISION MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Isis Salviano Soares de Amorim, Isabelle Xavier Dias, Daphne Pinheiro, Simone Nunes de Carvalho, Pedro Nicolau-Neto, Juliana Alves Rodrigues, Priscyanne Barreto Siqueira, Matheus da Silva Oliveira, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Summary: In breast cancer, hypoxia is associated with poor prognosis. The tumor suppressor SAV1 is downregulated in cancer cells, but its expression profile and importance in BC are limited. This study aimed to investigate SAV1 expression under normoxia and hypoxia, and its potential in BC prognosis. The results showed that SAV1 expression is lower in BC samples and tumor cell lines compared to normal samples. Lower levels of SAV1 were associated with worse survival curves and may be a risk factor for BC.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Camila Amaral Coracini, Matheus Felipe Zazula, Mariane Okamoto Ferreira, Janaina Carla da Silva, Suellen Ribeiro da Silva Scarton, Carolina Panis, Taciane Stein da Silva Leal, Gladson Ricardo Flor Bertolini
Summary: Gouty arthritis is an inflammatory disease causing pain and joint stiffness. This study aimed to evaluate the effects of photobiomodulation on gouty arthritis using rats as an experimental model. The results showed that photobiomodulation therapy reduced edema, improved joint function, increased pain threshold, activated the antioxidant system, and enhanced the inflammatory response. Therefore, photobiomodulation can be an effective therapeutic option for improving functional status in joint diseases.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Rodrigo Kern, Janaina Carla da Silva, Fabio Negretti, Mariane Okamoto Ferreira, Matheus Iago Oliveira Coletto, Stefania Tagliari de Oliveira, Fernanda Mara Alves, Thalita Basso Scandolara, Daniel Rech, Carolina Panis
Summary: Recent evidence suggests that CTLA-4 expression is a poor prognosis factor in breast cancer. This study investigated the implications of CTLA-4 expression on circulating inflammatory mediators in breast cancer patients. The results showed that CTLA-4 expression in tumor-infiltrating leukocytes (TILs) correlated with triple-negative breast tumors and was associated with lower levels of IL-12 in plasma. CTLA-4 expression in both tumor and TILs affected the systemic inflammatory status and correlated with more aggressive disease.
Article
Medicine, Research & Experimental
Ellen Mayara Souza Cruz, Virginia Marcia Concato, Juliana Maria Bitencourt de Morais, Taylon Felipe Silva, Fabricio Seidy Ribeiro Inoue, Milena de Souza Cremer, Danielle Lazarin Bidoia, Rayanne Regina Beltrame Machado, Luiz Gustavo de Almeida Chuffa, Mario Sergio Mantovani, Carolina Panis, Wander Rogerio Pavanelli, Fabio Rodrigues Ferreira Seiva
Summary: This study investigated the antitumor effects of melatonin on hepatocellular carcinoma (HCC) using HuH 7.5 cells. The results showed that melatonin reduced cell motility, caused changes in cell structure, and inhibited the Warburg effect by regulating lactate dehydrogenase activity. These findings suggest that melatonin could be a promising candidate for adjuvant therapy in HCC treatment.
Article
Developmental Biology
Fernanda Mithie Ogo, Glaucia Eloisa Munhoz Lion Siervo, Ana Maria Praxedes, Henrique Rodrigues Vieira, Suellen Ribeiro da Silva Scarton, Ana Tereza Guimaraes Bitencourt, Arielle Cristina Arena, Andrea Name Colado Simao, Marina Trevizan Guerra, Paulo Cesar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes
Summary: This study aimed to evaluate the impact of maternal exposure to continuous light during pregnancy on the adult reproductive system in female offspring. The results showed that continuous light exposure during the intrauterine period resulted in reduced LH levels and increased progesterone levels, uterine injuries, increased number of endometrial glands, and reduced antioxidant enzyme activity in the uterus of female offspring.
BIRTH DEFECTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Maria Beatriz Madureira, Virginia Marcia Concato, Ellen Mayara Souza Cruz, Juliana Maria Bitencourt de Morais, Fabricio Seidy Ribeiro Inoue, Natalia Concimo Santos, Manoela Daniele Goncalves, Milena Cremer de Souza, Thalita Basso Scandolara, Mariane Fontana Mezoni, Murilo Galvani, Fabio Rodrigues Ferreira Seiva, Carolina Panis, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: Citrus fruits are important sources of bioactive compounds with antioxidant properties, such as flavonoids. Naringenin and hesperidin are emerging compounds with potential anticancer effects, particularly for breast cancer. This review discusses the mechanisms by which naringenin and hesperidin can serve as therapeutic tools and alternative treatment sources for breast cancer.
Article
Medicine, Research & Experimental
Pamella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, Thalita Basso Scandolara, Janoario Athanazio de Souza, Daniel Rech, Janaina Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, Danielle Venturini, Carolina Panis
Summary: This study compared eutrophic and overweight/obese breast cancer patients to investigate the clinical significance of systemic nitric oxide metabolites (NOx) and the factors determining disease prognosis. Plasma samples from 61 women with breast cancer were analyzed using the cadmium-copper-Griess method. The results showed that NOx levels were significantly higher in overweight patients with Luminal B tumors compared to eutrophic patients with the same subtype. Eutrophic postmenopausal patients had significantly lower NOx levels compared to overweight postmenopausal patients. Additionally, eutrophic patients with tumor sizes between 2 and 5 cm had lower NOx levels compared to overweight patients with tumors of the same size range. These findings highlight the impact of trophic-adipose status and prognostic factors on circulating NOx levels in breast cancer patients.
PRECISION MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Ruan Gabriel Soares da Silva, Mariane Okamoto Ferreira, Isabella Mitsu Suo Komori, Henrique Rodrigues Menezes Oliveira, Murilo Galvani Machado, Julia Fernandes Gois Orrutea, Fernanda Mara Alves, Hellen dos Santos Jaques, Janaina Carla da Silva, Janoario Athanazio de Souza, Daniel Rech, Carolina Panis
Summary: Studies have shown a high incidence of various tumors, including breast cancer, in populations exposed to pesticides. This exposure is not only associated with direct DNA damage but also with epigenetic modifications and inflammation mediators, indicating genomic instability. The present study analyzed the inflammatory changes in the breast tissue of occupationally exposed women without cancer and found an inflammatory signature associated with pesticide exposure, which may trigger genetic mutations and breast carcinogenesis.
FRONTIERS IN PUBLIC HEALTH
(2023)
Meeting Abstract
Clinical Neurology
B. L. Fadel, N. Woldmar, G. Poralla, J. Fontes, L. Giacomin, M. Figueiredo, J. Evaristo, F. Nogueira, C. Panis, A. Rosso, L. Pizzatti
MOVEMENT DISORDERS
(2023)
Article
Biology
M. Camiccia, L. Z. P. Candiotto, S. C. Gaboardi, C. Panis, L. B. M. Kottiwitz
Summary: The aim of this study was to investigate the presence of glyphosate in breast milk and maternal environmental exposure. The study found that glyphosate was detected in all breast milk samples and in drinking water samples from both urban and rural areas. The study also estimated a significant amount of glyphosate ingested by breastfeeding babies in a 6-month period, indicating that the studied population was exposed to glyphosate through the environment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Thalita Basso Scandolara, Janaina Carla da Silva, Fernanda Mara Alves, Jessica Malanowski, Stefania Tagliari de Oliveira, Vitor Teixeira Maito, Daniel Rech, Carolina Panis, Cibele Bonvicino
Summary: This study investigated the levels of lipid peroxidation (LPO) in tumor and plasma samples from breast cancer patients, and found that high LPO levels were associated with poor prognosis parameters.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2022)
