Article
Oncology
Julieta Leone, Rachel A. Freedman, Nancy U. Lin, Sara M. Tolaney, Carlos T. Vallejo, Bernardo A. Leone, Eric P. Winer, Jose Pablo Leone
Summary: This study revealed significant differences in survival outcomes by tumor subtype among male breast cancer patients. Specifically, triple-negative tumor subtype had the worst survival outcomes. Stage, tumor subtype, and race were found to be significantly associated with overall survival and breast cancer-specific survival.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
F. Schettini, O. Martinez-Saez, C. Falato, I. De Santo, B. Conte, I. Garcia-Fructuoso, R. Gomez-Bravo, E. Segui, N. Chic, F. Braso-Maristany, L. Pare, M. Vidal, B. Adamo, M. Munoz, T. Pascual, E. Ciruelos, C. M. Perou, L. A. Carey, A. Prat
Summary: This study conducted a trial-level meta-analysis on hormone receptor-positive metastatic breast cancer and found that non-LumA disease is associated with poorer progression-free survival and overall survival compared to LumA disease, regardless of HER2, treatment, and menopausal status.
Article
Oncology
Gabriela Bezerra Nobrega, Bruna Salani Mota, Gabriela Boufelli de Freitas, Jonathan Yugo Maesaka, Rosa Maria Salani Mota, Rodrigo Goncalves, Angela Francisca Trinconi, Marcos Desiderio Ricci, Jose Roberto Piato, Jose Maria Soares-Jr, Edmund Chada Baracat, Jose Roberto Filassi
Summary: BCS is associated with superior OS rates compared to MS in patients with LABC following NAT. Lower BMI, lower pretreatment stage, and achieving PCR were associated with improved survival outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yujiao Deng, Hongtao Li, Yi Zheng, Zhen Zhai, Meng Wang, Shuai Lin, Yizhen Li, Bajin Wei, Peng Xu, Ying Wu, Xinyue Deng, Si Yang, Jun Lyu, Jingjing Hu, Huaying Dong, Zhijun Dai
Summary: Patients with locally advanced breast cancer (LABC) who underwent postoperative radiotherapy showed improved overall survival compared to those who received preoperative radiotherapy, indicating that preoperative radiotherapy did not present a better survival outcome than postoperative radiotherapy for LABC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Fangxu Yin, Song Wang, Chong Hou, Yiyuan Zhang, Zhenlin Yang, Xiaohong Wang
Summary: This study developed two accurate prediction models for survival outcomes in locally advanced breast cancer patients, which were more accurate than conventional TNM staging. These models can guide clinical decision-making and treatment planning for these patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Alexandra Moisand, Mathilde Madery, Thomas Boyer, Charlotte Domblides, Celine Blaye, Nicolas Larmonier
Summary: Breast cancers are a heterogeneous group of diseases with varying responses to current therapies. Hormone receptor-positive breast cancers can benefit from endocrine therapies, but metastatic disease remains a challenge. Immunotherapies have had limited success in breast cancer, only benefiting patients with hormone receptor-negative tumors. Current research focuses on the role of hormone receptor signaling in the sensitivity of breast cancer cells to anti-tumor immune responses and the potential of hormone therapy agents to enhance immune-based interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Joel S. Parker, Michael Mullins, Maggie C. U. Cheang, Samuel Leung, David Voduc, Tammi Vickery, Sherri Davies, Christiane Fauron, Xiaping He, Zhiyuan Hu, John F. Quackenbush, Inge J. Stijleman, Juan Palazzo, J. S. Marron, Andrew B. Nobel, Elaine Mardis, Torsten O. Nielsen, Matthew J. Ellis, Charles M. Perou, Philip S. Bernard
Summary: This study developed a risk model that incorporates gene expression-based intrinsic subtypes for breast cancer prognosis and prediction of chemotherapy benefit. The intrinsic subtypes showed significant prognostic significance and remained significant even when standard parameters were incorporated. The model can be used to predict prognosis for node-negative breast cancer and assess the likelihood of efficacy from neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Luczynska, Tomasz Piegza, Joanna Szpor, Sylwia Heinze, Tadeusz Popiela, Jaromir Kargol, Wojciech Rudnicki
Summary: With breast cancer being the most common malignant neoplasm globally, there is a greater demand for new techniques for early detection. This study explores the link between radiology and pathology, aiming to determine if tumor types can be identified through contrast-enhanced mammography and whether this knowledge can contribute to precision medicine.
Article
Oncology
Masanori Oshi, Shipra Gandhi, Yoshihisa Tokumaru, Li Yan, Akimitsu Yamada, Ryusei Matsuyama, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
Summary: In ER-positive/HER2-negative breast cancer, high EGFR expression is associated with improved survival and an anti-cancer immune microenvironment; conversely, TNBC with higher EGFR expression has lower immune cell infiltration.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Lin Wang, Qian Li, Vasily N. Aushev, Alfred Neugut, Regina M. Santella, Susan Teitelbaum, Jia Chen
Summary: This study suggests that additional PAM50-based subtyping can provide better prognostic stratification and improve disease management, especially for HR+ patients, particularly those who are HR+/HER2-.
Article
Oncology
Liubov A. Tashireva, Nataliya O. Popova, Anna Yu. Kalinchuk, Viktor E. Goldberg, Elena I. Kovalenko, Elena V. Artamonova, Aleksey G. Manikhas, Dmitriy M. Ponomarenko, Nataliya V. Levchenko, Elena I. Rossokha, Svetlana Yu. Krasilnikova, Marina A. Zafirova, Evgeniy L. Choynzonov, Vladimir M. Perelmuter
Summary: This study reveals that evaluating the composition of immune cells in the tumor microenvironment can predict the effectiveness of eribulin treatment and overall survival in patients with locally advanced or metastatic triple-negative breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Mengjia Hu, Virginia Brown, Joshua M. Jackson, Harshani Wijerathne, Harsh Pathak, Devin C. Koestler, Emily Nissen, Mateusz L. Hupert, Rolf Muller, Andrew K. Godwin, Malgorzata A. Witek, Steven A. Soper
Summary: Extracellular vesicles (EVs) have the potential to be used as a minimally invasive liquid biopsy marker for precision medicine, as they carry RNA cargo associated with the cell-of-origin. Researchers have developed an EV microfluidic affinity purification (EV-MAP) chip, made from plastic for high-scale production, which can isolate EV subpopulations. They demonstrated the utility of this chip in molecular subtyping breast cancer patients, isolating two subpopulations of EVs that better recapitulate the tumor microenvironment. The EV-MAP provided high recovery and specificity based on exosomal mRNA and PCR results, and the EV subpopulations showed potential for prognostication using the PAM50 test.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Zahra Hayati, Vahid Montazeri, Nitin Shivappa, James R. Hebert, Saeed Pirouzpanah
Summary: This study explored the association between diet-associated inflammation and the risk of different molecular subtypes of breast cancer in Iranian women. The results showed that a proinflammatory diet, indicated by higher E-DII scores, significantly increased the risk of breast cancer, especially for lobular carcinoma. Women with the highest intake of proinflammatory foods were also three times more likely to have triple-negative breast cancer compared to luminal A breast cancer.
Article
Multidisciplinary Sciences
Manuela Gago-Dominguez, Carmen M. Redondo, Manuel Calaza, Marcos Matabuena, Maria A. Bermudez, Roman Perez-Fernandez, Maria Torres-Espanol, Angel Carracedo, J. Esteban Castelao
Summary: The study revealed an association between LIPG and breast cancer, particularly in specific conditions including pre-menopausal breast cancer, Luminal A breast cancers, HER2-negative breast cancers, women with high total cholesterol levels, non-postpartum breast cancer, and grades II and III breast cancers.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Galia Jacobson, Orit Kaidar-Person, Ory Haisraely, Shira Galper, Tatiana Rabin, Ilanit Dromi Shahadi, Yaacov Richard Lawrence, Zvi Symon, Merav Akiva Ben-David
Summary: Both single fraction and fractionated radiation therapy were effective for palliative treatment, with fractionated therapy showing a more durable response. As a result of equivalent palliative outcomes, there has been an increasing trend towards using single fraction radiation therapy for palliation during the COVID-19 pandemic.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Raffit Hassan, Anish Thomas, John J. Nemunaitis, Manish R. Patel, Jaafar Bennouna, Franklin L. Chen, Jean-Pierre Delord, Afshin Dowlati, Samith T. Kochuparambil, Matthew H. Taylor, John D. Powderly, Ulka N. Vaishampayan, Claire Verschraegen, Hans Juergen Grote, Anja von Heydebreck, Kevin Chin, James L. Gulley
Editorial Material
Oncology
Vincent Vinh-Hung, Nam P. Nguyen, Claire Verschraegen
Meeting Abstract
Oncology
Bhavana Konda, Sherise C. Rogers, Cassandra Natalie Grenade, Claire F. Verschraegen, Ye Zhou, Ashima Goyal, Mona Natwa, Chadwick Wright, Akram Hussein, Hallie Barr, Dramane Konate, Andrew Brown, Rochelle Batdorf, Bonnie Williams, Songzhu Zhao, Lai Wei, Manisha H. Shah
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Vincent Vinh-Hung, Kadiatou Diakite, Clarisse Joachim, Stefanos Bougas, Cristina Ioana Furtos, Jean-Marc Rakotonarivo, Wadah Lababidi, Eva Papadopoulou, Patrick Escarmant, Jacqueline Veronique-Baudin, Claire F. Verschraegen
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Mingjia Li, Daniel Spakowicz, Jarred Burkart, Sandip Patel, Marium Husain, Kai He, Erin M. Bertino, Peter G. Shields, David P. Carbone, Claire F. Verschraegen, Carolyn J. Presley, Gregory A. Otterson, Kari Kendra, Dwight H. Owen
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
April M. Averill, Hibba Tul Rehman, Joseph W. Charles, Timothy A. Dinh, Karamatullah Danyal, Claire F. Verschraegen, Gary S. Stein, Wolfgang R. Dostmann, Jon E. Ramsey
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Oncology
Ming Yin, Jing Zhao, Paul Monk, Douglas Martin, Edmund Folefac, Monika Joshi, Ning Jin, Amir Mortazavi, Claire Verschraegen, Steven Clinton
Article
Multidisciplinary Sciences
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D'Alessandro, Mercedes Rincon
Summary: Chemotherapy is the standard treatment for most cancers worldwide, but chemoresistance due to ABC transporters is a significant challenge. The study highlights the role of mitochondrial respiration in supplying ATP for ABC transporters, and how inhibiting mitochondrial respiration can overcome chemoresistance. Development of MCJ mimetics offers a potential alternative strategy for treating multiple cancers by targeting this mechanism.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Hugo Arias-Pulido, Ashley Marie Cimino-Mathews, Nabila Chaher, Clifford Ray Qualls, Nancy Joste, Cecile Colpaert, Jonathan Douglas Marotti, Mary Dickinson Chamberlin, Maxwell Gabriel Foisey, Eric Robert Prossnitz, Leisha Ann Emens, Steven Fiering
Summary: This study evaluated epidemiologic and immune factors associated with pCR, BCSS, and DFS outcomes in IBC and LABC patients. High TILs, PD-L1(+) carcinoma cells, and combined CD20(+) and PD-L1(+) carcinoma cells were correlated with pCR in both IBC and LABC patients, with pCR correlating with improved BCSS and DFS outcomes.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F. Steinmetz, Maria Suarez-Redondo, Johannes Vom Berg, Laura Pena, Hugo Arias-Pulido
Summary: In situ eCPMV immunotherapy has demonstrated anti-tumor efficacy and improved survival in IMC patients, suggesting its potential as a groundbreaking immunotherapy for both canine IMC and human IBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Cell Biology
Daniel Alonso-Miguel, Steven Fiering, Hugo Arias-Pulido
Summary: Inflammatory breast cancer (IBC) is a highly metastatic form of breast cancer with no specific treatments. Recent research shows that combining immune therapy with chemotherapy can improve the prognosis of IBC patients. Direct injection of immunostimulatory agents into the tumor is proposed as a safe, effective, and cost-effective option for improving outcomes in IBC patients.
Article
Cell Biology
Guillermo Valdivia, Daniel Alonso-Miguel, Maria Dolores Perez-Alenza, Anna Barbara Emilia Zimmermann, Evelien Schaafsma, Fred W. Kolling, Lucia Barreno, Angela Alonso-Diez, Veronique Beiss, Jessica Fernanda Affonso de Oliveira, Maria Suarez-Redondo, Steven Fiering, Nicole F. Steinmetz, Johannes vom Berg, Laura Pena, Hugo Arias-Pulido
Summary: This study explores a novel immunotherapy approach and shows that intratumoral immunotherapy with eCPMV can effectively reduce tumor volume in breast cancer without any adverse effects. The results suggest that this method has the potential to improve treatment outcomes for breast cancer patients.
Meeting Abstract
Oncology
B. Hrinczenko, D. Spigel, N. Iannotti, H. P. Safran, M. H. Taylor, J. Bennouna, S. Goel, J. Leach, D. J. Wong, K. Kelly, C. Verschraegen, M. Bajars, J. Manitz, M. Ruisi, J. L. Gulley
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
Daniel Spakowicz, Marium Husain, Gabriel Tinoco, Sandip H. Patel, Jarred Thomas Burkart, Claire F. Verschraegen, Kari Lynn Kendra, Sarah Hoffman, Jennifer Philippon, Dionisia Marie Quiroga, Gregory Alan Otterson, Dwight Hall Owen
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Letter
Medicine, General & Internal
Ming Yin, Vincent Vinh-Hung, Claire Verschraegen
NEW ENGLAND JOURNAL OF MEDICINE
(2019)