Review
Genetics & Heredity
F. Isabella Zampeta, Ben Distel, Ype Elgersma, Rik Iping
Summary: This study reviews the development of Angelman syndrome research over the past 50 years using a bibliometric approach. The results reveal a shift in research focus towards genetic therapies for Angelman syndrome and provide insights into changes in funding sources, publishing journals, and international collaborations.
Review
Immunology
Maoyu Wang, Zhensheng Zhang, Zhizhou Li, Yasheng Zhu, Chuanliang Xu
Summary: With the increasing incidence of bladder cancer, there has been a focus on understanding its mechanism and developing new treatment strategies. The introduction of immune checkpoint inhibitor-based immunotherapy has shown great promise in treating advanced bladder cancer and improving patients' survival. The ubiquitin-proteasome system, which plays a crucial role in various biological processes, has been found to be involved in bladder cancer. This review summarizes the recent progress in understanding the role of E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and highlights their implications for bladder cancer immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Xiu Yin, Qingbin Liu, Fen Liu, Xinchen Tian, Tinghao Yan, Jie Han, Shulong Jiang
Summary: This review summarizes the role of ubiquitination in tumorigenesis and related signaling pathways, aiming to provide a reference for future exploration of ubiquitination and potential targets for cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Angel S. N. Ng, Shibo Zhang, Victor C. Y. Mak, Yuan Zhou, Yin Yuen, Rakesh Sharma, Yiling Lu, Guanglei Zhuang, Wei Zhao, Herbert H. Pang, Lydia W. T. Cheung
Summary: In this study, it is discovered that loss of AKTIP on 16q12.2 drives tumorigenesis of estrogen receptor alpha (ERa)-positive breast cancer and is associated with poor prognosis. Loss of AKTIP leads to increased ERa protein level and activity, as well as activation of JAK2-STAT3 pathway as alternative survival signal when ERa is inhibited. AKTIP loss also confers resistance to ERa antagonists in breast cancer cells, which can be overcome by co-inhibition of JAK2/STAT3.
Article
Biochemistry & Molecular Biology
Xin Bai, Jianming Tang
Summary: This article provides a comprehensive review of the roles and molecular mechanisms of tripartite motif (TRIM) proteins in breast cancer. It highlights their importance in breast cancer treatment and suggests that TRIM proteins may be ideal targets for breast cancer therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yayun Gu, Huanyao Gao, Huan Zhang, August John, Xiujuan Zhu, Suganti Shivaram, Jia Yu, Richard M. Weinshilboum, Liewei Wang
Summary: The TRAF4-SMURF2 complex is identified as a potential mechanism for maintaining HER2 signaling in HER2-positive breast cancer cells during Trastuzumab treatment. Knockdown of TRAF4 reduces HER2 stability and improves Trastuzumab sensitivity.
Review
Endocrinology & Metabolism
Zhen Ye, Jingru Yang, Hanming Jiang, Xianquan Zhan
Summary: Malignant lung cancer has a high incidence and poor prognosis, while the ubiquitination enzyme pathway plays a crucial role in protein degradation. Ubiquitination of proteins has different effects, and multiple short chains of ubiquitination residues are favorable for protein degradation. The balance between protein ubiquitination and deubiquitination is beneficial to the health of the organism, and imbalances in these pathways are associated with diseases such as lung cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caiyue Li, Hyemin Lee, Ji Hoon Jung, Yiwei Zhang, Jieqiong Wang, Chang Liu, Roger L. Sheffmaker, Allyson M. Segall, Shelya X. Zeng, Hua Lu
Summary: This study discovered that CCDC3 acts as a tumor suppressor in breast cancer by enhancing p53 activity and inhibiting cell proliferation and tumor growth. High levels of CCDC3 are associated with higher overall survival and lower cancer relapse in patients. This mechanism provides a potential therapeutic target for breast cancer treatment.
Article
Biochemistry & Molecular Biology
Ran Sun, Jin He, Qin Xiang, Yixiao Feng, Yijia Gong, Yijiao Ning, Chaoqun Deng, Kexin Sun, Mingjun Zhang, Zhaobo Cheng, Xin Le, Qi Xiong, Fengsheng Dai, Yongzhong Wu, Tingxiu Xiang
Summary: Breast cancer metastasis can occur even with a small primary tumor. Neurotrophin 4 (NTF4) has been found to play a dual role in breast cancer by promoting proliferation and metastasis. High levels of NTF4, especially in early stages, are associated with poor clinical outcomes, emphasizing the importance of metastasis in breast cancer mortality. Mechanistically, NTF4 activates specific pathways to promote epithelial-mesenchymal transition and cell motility, while inhibiting cell proliferation and promoting apoptosis. These findings suggest that NTF4 could be a prognostic marker and potential therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Yalong Yang, Jinxuan Hou, Jiuyang Liu, Sudhanshu Bhushan, Gaosong Wu
Summary: Macrophage is an important sentinel cell type of the innate immune system and plays a critical role in antigen presentation and bridging the innate and adaptive immune responses. Tumor-associated macrophages (TAMs) have been shown to have potential opposite functions in different tumor models, highlighting the importance of repolarizing TAM subtypes in cancer treatment. In breast cancer, the localization of resident macrophages determines their cell markers and functions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Virology
Pankaj Chaudhary, Jessica Proulx, In -Woo Park
Summary: UBE3A is a ubiquitin-protein ligase involved in regulating protein degradation and has been found to play a role in viral pathology and human diseases. It regulates the stability of viral proteins in infected cells and is also associated with neurodevelopmental disorders and transcriptional coactivation of steroid hormone receptors. These diverse functions highlight the importance of UBE3A in disease formation and virus regulation.
Article
Biochemistry & Molecular Biology
Hang Chen, Rui Yang, Lei Xing, Bin Wang, Dawei Liu, Xiaoqiang Ou, Yumei Deng, Rong Jiang, Junxia Chen
Summary: This study identified a novel hypoxia-induced circRNA, circPFKFB4, and demonstrated its role in promoting breast cancer progression. The study revealed an interaction between circPFKFB4 and the CRL4DDB2 E3 ubiquitin ligase and suggested circPFKFB4 as a potential biomarker and therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Laura A. Hehl, Brenda A. Schulman
Summary: Tsai et al.1 and Mark et al.2 show that the E3 ligase UBR5 mediates broad regulation by selectively targeting agonist-bound nuclear hormone receptors, MYC, and other transcriptional regulators not incorporated into active gene expression complexes.
Article
Cell Biology
Zhe Zhao, Mei Meng, Jun Yao, Hao Zhou, Yu Chen, Juntao Liu, Jie Wang, Yuxi Liu, Yingnan Qiao, Mengli Zhang, Jindan Qi, Tong Zhang, Zhou Zhou, Tao Jiang, Bingxue Shang, Quansheng Zhou
Summary: Expression of the long non-coding RNA KRT7-AS is downregulated in breast and lung cancers, leading to increased tumorigenesis and decreased apoptosis. Silencing of KRT7-AS in lung cancer cells enhances oncogenic Keratin-7 levels and tumorigenesis, while overexpression of KRT7-AS inhibits tumorigenesis. KRT7-AS also increases cancer cell sensitivity to cisplatin and promotes apoptosis. The RXRa-KRT7-AS-PTEN signaling axis controls carcinogenesis and apoptosis, and may provide a new therapeutic target for cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Gwen R. Buel, Xiang Chen, Wazo Myint, Olumide Kayode, Varvara Folimonova, Anthony Cruz, Katarzyna A. Skorupka, Hiroshi Matsuo, Kylie J. Walters
Summary: The E3 ligase E6AP/UBE3A has a specific binding site in the 26S proteasome provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Based on RAZUL sequence similarity, it is demonstrated that E6AP AZUL transiently binds to the UBA domain of proteasomal shuttle factor UBQLN1/2. Despite weak affinity, E6AP AZUL is recruited to UBQLN2 biomolecular condensates in vitro and interacts with UBQLN1/2 in cells, indicating the AZUL:UBA interaction mediates E6AP recruitment.