期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 131, 期 1, 页码 321-324出版社
SPRINGER
DOI: 10.1007/s10549-011-1784-8
关键词
Gene expression profile; Microarray; Dual-species; Cross-hybridization; Xenograft model; Tumor stroma; Tumor microenvironment
类别
Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.
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