Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Oncology
Sara P. Lester, Aparna S. Kaur, Suneela Vegunta
Summary: This review examines emerging evidence for the association of modifiable factors on mammographic breast density (MBD) and the influence of MBD on breast cancer risk, recommending that patients be counseled on modifiable risk factors to tailor breast cancer prevention strategies.
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Article
Medical Laboratory Technology
Ann Vissing Landgrebe, Morten Asp Vonsild Lund, Ulrik Lausten-Thomsen, Christine Frithioff-Bojsoe, Cilius Esmann Fonvig, Johanne Lind Plesner, Louise Aas Holm, Thomas Jespersen, Torben Hansen, Jens Christian Holm
Summary: Concentrations of PTH, vitamin D, calcium, and phosphate in children and adolescents vary with age, sex, and season, which should be taken into consideration when screening for and treating imbalances in bone metabolism.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Maria Phylactou, Alexander N. Comninos, Ahmed Salih, Marina Labib, Pei Chia Eng, Sophie A. Clarke, Pope Moore, Tricia Tan, Jaimini Cegla, Waljit S. Dhillo, Ali Abbara
Summary: Background: TCa is commonly adjusted for albumin using established formulae to estimate Ca2+. This study derived a novel formula and compared its performance to existing formulae in predicting Ca2+. Conclusion: The newly derived formula showed improved prediction of Ca2+ compared to established formulae, indicating the need for further studies to optimize TCa adjustment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Article
Endocrinology & Metabolism
David Gillis, Ari Hefter, Shalom Edri, David Strich
Summary: The aim of this study was to determine the optimal pediatric levels of 25-hydroxy-vitamin D (25OHD) for bone health. The study analyzed a large dataset of 49,935 25OHD tests from children sampled between 2009 and 2019. Significant correlations were found between 25OHD levels and parathyroid hormone (PTH) and calcium, indicating that increasing 25OHD levels up to at least 100 nmol/l can improve bone mineralization.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Ning Xie, Jiale Xie, Ziwei Wang, Qiuai Shu, Haitao Shi, Jinhai Wang, Na Liu, Feng Xu, Jian Wu
Summary: This study utilized a two-sample Mendelian randomization (MR) analysis to explore the causal effects among calcium, vitamin D (Vit-D), parathyroid hormone (PTH), and irritable bowel syndrome (IBS). The results did not find any causal relationship between serum calcium, Vit-D levels, and the risk of IBS. However, there was an association between genetic predisposition to IBS and decreased levels of PTH.
Review
Endocrinology & Metabolism
Ignacio Portales-Castillo, Petra Simic
Summary: Bone-mineral ion regulators, such as PTH, FGF23, Klotho, and 1,25(OH)2 vitamin D, play important roles in calcium and phosphate metabolism and cell signaling. These factors are tightly regulated through genetic, epigenetic, and post-translational mechanisms. Epigenetic mechanisms, including DNA methylation and histone modification, have been found to affect the function of these regulators.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Nahid Tabibzadeh, Angelo Karaboyas, Bruce M. Robinson, Philipp A. Csomor, David M. Spiegel, Pieter Evenepoel, Stefan H. Jacobson, Pablo-Antonio Urena-Torres, Masafumi Fukagawa, Issa Al Salmi, Xinling Liang, Ronald L. Pisoni, Eric W. Young
Summary: The study found that patients with higher PTH levels before starting hemodialysis were more likely to be prescribed active vitamin D and calcimimetics during the first year of hemodialysis. Additionally, these patients had a higher risk of having PTH levels greater than 600pg/mL 9-12 months after starting hemodialysis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Oncology
Shadi Azam, Mikael Eriksson, Arvid Sjolander, Marike Gabrielson, Roxanna Hellgren, Kamila Czene, Per Hall
Summary: The study revealed that mammographic microcalcification clusters are an independent risk factor for breast cancer, with a higher estimated risk in premenopausal women. For postmenopausal women, microcalcification clusters and mammographic density have a similar influence on breast cancer risk, and there is no interaction between the two factors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Surgery
Reshi Suthakaran, Imeshi Indigahawela, Krinal Mori, Kiat Lim, Ahmad Aly
Summary: This study investigated the variations in serum calcium, vitamin D, and parathyroid hormone levels following Roux-en-Y Gastric bypass (RYBP) and Sleeve Gastrectomy (SG), finding significant improvements in calcium and vitamin D levels postoperatively for both procedures. However, higher parathyroid hormone (PTH) levels were observed following RYBP compared to SG, indicating the need for tailored supplementation protocols for patients with high preoperative PTH levels undergoing RYBP to prevent deficiencies.
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Oncology
Ellie Darcey, Nina McCarthy, Eric K. Moses, Christobel Saunders, Gemma Cadby, Jennifer Stone
Summary: This study systematically assessed mammographic breast density as an endophenotype for breast cancer and confirmed its association with disease risk and heritability in two independent samples.
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Allergy
Howard H. F. Tang, Anna Lang, Shu Mei Teo, Louise M. Judd, Ronald Gangnon, Michael D. Evans, Kristine E. Lee, Rose Vrtis, Patrick G. Holt, Robert F. Lemanske, Daniel J. Jackson, Kathryn E. Holt, Michael Inouye, James E. Gern
Summary: The developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses are associated with the risk of childhood asthma. A Staphylococcus-dominant microbiome in early infancy is linked to an increased risk of recurrent wheezing and persistent asthma, while detection of rhinoviruses and predominance of Moraxella during wheezing illnesses are associated with asthma that persists throughout later childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Mathematical & Computational Biology
Junho Lee, Maria E. Kamenetsky, Ronald E. Gangnon, Jun Zhu
Summary: This article proposes a varying coefficient regression method for spatio-temporal data, which can identify clusters of regression coefficients over space and time, extending from spatial-only data. The methodology is validated through a simulation study and applied to a cancer mortality dataset in the Southeast of the U.S.
STATISTICS IN MEDICINE
(2021)
Article
Critical Care Medicine
Timothy Choi, Mark Devries, Leonard B. Bacharier, William Busse, Carlos A. Camargo, Robyn Cohen, Gregory P. Demuri, Michael D. Evans, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Petra LeBeau, Kristine E. Lee, Peter N. Le Souef, Andrew Liu, David T. Mauger, Carole Ober, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Ronald Gangnon, Daniel J. Jackson, Robert F. Lemanske, James E. Gern, Yury A. Bochkov
Summary: This study analyzed longitudinal data to investigate the impact of age and other factors on susceptibility to RV-C infections. The results showed that while RV-A and RV-C infections were similar in infancy, RV-C detection decreased with age while neutralizing antibody prevalence increased. The ratio of RV-C to RV-A detection during illnesses was found to be related to age, genetics, and wheezing illnesses, indicating potential factors influencing susceptibility to RV-C.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Chunling Hu, Steven N. Hart, Rohan Gnanaolivu, Hongyan Huang, Kun Y. Lee, Jie Na, Chi Gao, Jenna Lilyquist, Siddhartha Yadav, Nicholas J. Boddicker, Raed Samara, Josh Klebba, Christine B. Ambrosone, Hoda Anton-Culver, Paul Auer, Elisa V. Bandera, Leslie Bernstein, Kimberly A. Bertrand, Elizabeth S. Burnside, Brian D. Carter, Heather Eliassen, Susan M. Gapstur, Mia Gaudet, Christopher Haiman, James M. Hodge, David J. Hunter, Eric J. Jacobs, Esther M. John, Charles Kooperberg, Allison W. Kurian, Loic Le Marchand, Sara Lindstroem, Tricia Lindstrom, Huiyan Ma, Susan Neuhausen, Polly A. Newcomb, Katie M. O'Brien, Janet E. Olson, Irene M. Ong, Tuya Pal, Julie R. Palmer, Alpa V. Patel, Sonya Reid, Lynn Rosenberg, Dale P. Sandler, Christopher Scott, Rulla Tamimi, Jack A. Taylor, Amy Trentham-Dietz, Celine M. Vachon, Clarice Weinberg, Song Yao, Argyrios Ziogas, Jeffrey N. Weitzel, David E. Goldgar, Susan M. Domchek, Katherine L. Nathanson, Peter Kraft, Eric C. Polley, Fergus J. Couch
Summary: This study provides population-based estimates of the prevalence and risk of breast cancer associated with pathogenic variants in known cancer-predisposition genes. The results highlight the varying levels of risk associated with different genes, such as high risk for BRCA1 and BRCA2 and moderate risk for PALB2, as well as associations with specific subtypes of breast cancer for genes like RAD51C and RAD51D.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Jessica Gorzelitz, Erin Costanzo, Ronald Gangnon, Kelli Koltyn, Amy Trentham Dietz, Ryan J. Spencer, Joanne Rash, Lisa Cadmus-Bertram
Summary: The study aimed to determine the feasibility of home-based muscle strengthening activity for endometrial cancer survivors. The results showed that the home-based program was feasible, with high participant satisfaction.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Health Care Sciences & Services
Patricia A. Zrelak, Garth H. Utter, Kathryn M. McDonald, Robert L. Houchens, Sheryl M. Davies, Halcyon G. Skinner, Pamela L. Owens, Patrick S. Romano
Summary: This study successfully reweighted the Patient Safety Indicator Composite (PSI 90) by incorporating excess harm, resulting in a more clinically meaningful distribution of component weights. The reweighted PSI 90 showed satisfactory reliability and discrimination, demonstrating the feasibility of using harm-based weights in patient safety evaluations.
HEALTH SERVICES RESEARCH
(2022)
Article
Engineering, Manufacturing
Sait Tunc, Oguzhan Alagoz, Elizabeth S. Burnside
Summary: Overdiagnosis of breast cancer is a significant problem that results in high costs for the U.S. healthcare system. This study focuses on optimizing breast cancer diagnostic decisions based on cancer types using a large-scale finite-horizon Markov decision process model. The results show that this model can reduce overdiagnosis rates by 20%.
PRODUCTION AND OPERATIONS MANAGEMENT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mai A. Elezaby, Lu Mao, Elizabeth S. Burnside, Margarita L. Zuley, Wendie A. Berg, Mythreyi Bhargavan-Chatfield, Cindy S. Lee
Summary: This study analyzed data from the ACR National Mammography Database and found that the utilization rate of BI-RADS 3 in diagnostic mammography was 15.5%, with a cancer yield of 0.91%. Calcifications, age over 70, and presence of prior comparisons were significantly associated with a higher likelihood of malignancy.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2022)
Article
Oncology
Jessica R. Schumacher, Heather B. Neuman, Menggang Yu, David J. Vanness, Yajuan Si, Elizabeth S. Burnside, Kathryn J. Ruddy, Ann H. Partridge, Deborah Schrag, Stephen B. Edge, Ying Zhang, Elizabeth A. Jacobs, Jeffrey Havlena, Amanda B. Francescatti, David P. Winchester, Daniel P. McKellar, Patricia A. Spears, Benjamin D. Kozower, George J. Chang, Caprice C. Greenberg
Summary: This study evaluated the association between different methods of detecting distant recurrence in breast cancer patients and survival rates, finding that asymptomatic imaging detection was associated with better outcomes for patients with estrogen receptor and progesterone receptor negative, HER2 negative or HER2 positive cancers. However, no association was observed in patients with estrogen receptor or progesterone receptor positive, HER2 negative cancers.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Elizabeth S. S. Burnside, Sarina Schrager, Lori DuBenske, Jon Keevil, Terry Little, Amy Trentham-Dietz, Betsy Rolland, Dhavan Shah, Oguzhan Alagoz
Summary: This study successfully developed a shared decision-making tool for breast cancer screening using interdisciplinary team science methods and quality improvement principles. Two iterative cycles of plan-do-study-act were conducted to develop and improve the tool, and patient and physician feedback and data supported its implementation. This study demonstrates the importance of team science and quality improvement in improving breast cancer screening.
JCO ONCOLOGY PRACTICE
(2023)
Article
Medical Informatics
Yan Liu, Rachel Kornfield, Ellie Fan Yang, Elizabeth Burnside, Jon Keevil, Dhavan V. V. Shah
Summary: This study examines how patterns of verbal communication and system use of a decision aid predict patients' satisfaction with shared decision making for screening mammography. The results suggest that providers' use of quantitative language and patients' question-asking are associated with different levels of satisfaction, and looping through the decision aid improves satisfaction.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Review
Medicine, Research & Experimental
Allan R. Brasier, Elizabeth S. Burnside, Betsy Rolland
Summary: A translational team is a type of interdisciplinary team that aims to improve human health. Understanding how to promote team performance in the areas of affect, communication, management, collaborative problem-solving, and leadership is essential. This study conducted a literature review to identify key competencies that enhance team performance and develop strategies for training interventions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Primary Health Care
Sarina Schrager, Brenna Bomcamp, Elizabeth Burnside
JOURNAL OF FAMILY PRACTICE
(2022)
Article
Medicine, Research & Experimental
Betsy Rolland, Linda Scholl, Sainath Suryanarayanan, Peggy Hatfield, Kate Judge, Christine Sorkness, Elizabeth Burnside, Allan R. Brasier
Summary: This study aims to intervene in cross-disciplinary translational teams through Collaboration Planning to improve team collaboration and management skills. The research found issues such as unclear member invitation, confusing questions, and lack of communication plans in the teams.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Natalie Guerrero, Ronald Gangnon, Marah A. Curtis, Carmen R. Valdez, Deborah B. Ehrenthal, Elizabeth A. Jacobs
Summary: The study found that maternal depression at a child's age of two has a negative impact on the child's internalizing and externalizing behavior, especially at the age of nine. Race/ethnicity did not moderate this relationship.
MATERNAL AND CHILD HEALTH JOURNAL
(2021)