Review
Oncology
Laura Garcia-Estevez, Javier Cortes, Silvia Perez, Isabel Calvo, Isabel Gallegos, Gema Moreno-Bueno
Summary: Breast cancer is the most common tumor in women globally, and the relationship between obesity and breast cancer risk is closely related to menopausal status. Obesity increases the risk of breast cancer in postmenopausal women but appears to be protective in premenopausal women.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Maret L. Maliniak, Jasmine Miller-Kleinhenz, Deirdre P. Cronin-Fenton, Timothy L. Lash, Keerthi Gogineni, Emiel A. M. Janssen, Lauren E. McCullough
Summary: Obesity is a known risk factor for postmenopausal breast cancer, especially hormone receptor-positive breast cancers, and is associated with poorer prognosis. Crown-like structures in breast adipose tissue (CLS-B) have been identified as a marker of local inflammation, with evidence linking their presence to metabolic and inflammatory factors contributing to breast cancer development and progression. However, further research is needed to determine the clinical utility of CLS-B as a marker for breast cancer risk or prognosis.
Review
Biochemistry & Molecular Biology
Yuan Wu, Xu Li, Qiong Li, Chienshan Cheng, Lan Zheng
Summary: The review examines mechanistic evidence for the connection between obesity and breast cancer, exploring the factors that promote tumor development or metastasis. It highlights the role of adipokines, metabolic pathways, inflammatory microenvironment, adipose stem cells, and miRNAs in breast cancer progression. The review also discusses possible therapeutic directions and the risks associated with autologous breast remodeling and fat transplantation. Furthermore, it explores the causes of the obesity paradox and the impact of enhanced immunity. Evaluating the balance between inflammation and immunity in obesity-induced breast cancer warrants further investigation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Ankita Deb, Bhavana Deshmukh, Pranay Ramteke, Firoz Khan Bhati, Manoj Kumar Bhat
Summary: Resistin, a small secretory molecule, is implicated in insulin resistance development under obese conditions. It is associated with metabolic disorders, cardiovascular diseases, and cancers. Studies suggest it plays a pivotal role in cancer cell proliferation, metastasis, inflammation, and metabolism.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karolina Hanusek, Jakub Karczmarski, Anna Litwiniuk, Katarzyna Urbanska, Filip Ambrozkiewicz, Andrzej Kwiatkowski, Lidia Martynska, Anita Domanska, Wojciech Bik, Agnieszka Paziewska
Summary: Obesity is associated with an increased risk of breast cancer through mechanisms involving inflammation, cell metabolism disorders, and hormonal metabolism disturbances. MicroRNAs may play a role in regulating these processes and could serve as potential biomarkers and targets for anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Noshin Mubtasim, Lauren Gollahon
Summary: Obesity-induced changes in secretory factors of white adipocytes enhance the motility and invasiveness of breast cancer cells. Phosphorylated FAK activates downstream effector proteins beta-catenin and MMP9, increasing breast cancer cell migration and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Daniela Nahmias-Blank, Ofra Maimon, Amichay Meirovitz, Kim Sheva, Tamar Peretz-Yablonski, Michael Elkin
Summary: Postmenopausal, obese women have a higher risk of developing estrogen receptor-positive (ER+) breast tumors, which are resistant to therapies. The relationship between obesity and breast cancer differs in pre-menopausal and post-menopausal women. Elucidation of the molecular mechanisms behind obesity-related breast tumors is critical for disease prevention and treatment. Understanding these mechanisms could potentially prevent and intervene in the promotion of breast cancer associated with excess adiposity.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Immunology
Elise Semerena, Alessio Nencioni, Krzysztof Masternak
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell metabolism and can also function in the extracellular space. Elevated levels of extracellular NAMPT have been associated with various inflammatory and metabolic disorders. This review summarizes the current knowledge on the biology of extracellular NAMPT, its proposed roles in disease pathogenesis, and its potential as a disease biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jianchun Wu, Kaitrin Kramer, David l L. Crowe
Summary: Obesity is the primary preventable cause of breast cancer, and the expression of the nuclear receptor PPAR & gamma; is altered in obese mice, leading to an increased risk of breast cancer. The increased expression of PPAR & gamma; in mammary epithelium of obese mice is associated with higher expression of solute carrier proteins, which contributes to the development of breast cancer.
Review
Endocrinology & Metabolism
Ximena M. Bustamante-Marin, Jenna L. Merlino, Emily Devericks, Meredith S. Carson, Stephen D. Hursting, Delisha A. Stewart
Summary: The global prevalence of obesity and overweight has tripled since 1975, with over 42.5% of adults in the United States being obese. Individuals with obesity often exhibit multiple metabolic disturbances, which are associated with an increased risk of many cancers, including breast cancer. In an obese state, interactions between adipocytes, immune cells, and breast epithelial cells via obesity-associated hormones, angiogenic factors, cytokines, and other mediators can enhance the risk and progression of breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Thu-Thi Pham, Katharina Nimptsch, Krasimira Aleksandrova, Mazda Jenab, Robin Reichmann, Kana Wu, Anne Tjonneland, Cecilie Kyro, Matthias B. Schulze, Rudolf Kaaks, Verena Katzke, Domenico Palli, Fabrizio Pasanisi, Fulvio Ricceri, Rosario Tumino, Vittorio Krogh, Jeanine Roodhart, Jesus Castilla, Maria-Jose Sanchez, Sandra Milena Colorado-Yohar, Justin Harbs, Martin Rutegard, Keren Papier, Elom K. Aglago, Niki Dimou, Ana-Lucia Mayen-Chacon, Elisabete Weiderpass, Tobias Pischon
Summary: This study found no association between pre-diagnostic circulating resistin concentrations and the risk of colorectal cancer (CRC). However, a marginal association was observed among cases diagnosed within the first two years of follow-up. Resistin is more likely a marker of existing tumors than a risk factor for CRC.
Article
Multidisciplinary Sciences
Nadia Obi, Audrey Y. Jung, Tabea Maurer, Marianne Huebner, Theron Johnson, Sabine Behrens, Stefanie Jaskulski, Heiko Becher, Jenny Chang-Claude
Summary: The study aimed to assess the role of post-diagnosis circulating adipokines on long-term prognosis in breast cancer patients. Overall, post-diagnosis adipokines were not associated with long-term outcomes, but higher concentrations of adiponectin in patients with ERPR negative tumors may be associated with increased breast cancer specific mortality.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
David N. Danforth
Summary: Chronic inflammation plays a significant role in breast cancer development, with factors like adipose tissue and obesity affecting early stages of carcinogenesis. The microbiome and genomic changes also contribute to inflammation, suggesting a role in the initiation, development, and progression of breast cancer.
Article
Multidisciplinary Sciences
Yen-Yun Wang, Amos C. Hung, Yi-Chia Wu, Steven Lo, Huan-Da Chen, Yuk-Kwan Chen, Ya-Ching Hsieh, Stephen Chu-Sung Hu, Ming-Feng Hou, Shyng-Shiou F. Yuan
Summary: This study demonstrated that resistin-stimulated ADSCs can interact with breast cancer cells in the tumor microenvironment by secreting CXCL5, leading to increased malignancy in breast cancer cells.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Masanori Oshi, Yoshihisa Tokumaru, Fernando A. Angarita, Lan Lee, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: Adipogenesis in breast cancer, particularly in triple negative breast cancer (TNBC), is associated with poorer survival, different tumor metabolism, and an unfavorable tumor immune microenvironment, which is distinct from the abundance of adipocytes.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Tein-Yao Chang, Bo-Jun Huang, Jun-Ren Sun, Cherng-Lih Perng, Ming-Chin Chan, Cheng-Ping Yu, Tzong-Shi Chiueh
MICROBIOLOGICAL RESEARCH
(2016)
Article
Oncology
Jar-Yi Ho, Ren-Jun Hsu, Jui-Ming Liu, Szu-Chi Chen, Guo-Shiou Liao, Hong-Wei Gao, Cheng-Ping Yu
Article
Biochemistry & Molecular Biology
Jhih-Liang Huang, Yijie Tang, Cheng-Ping Yu, Dev Sanyal, Xinglin Jia, Xinyu Liu, Yisong Guo, Wei-chen Chang
Article
Chemistry, Multidisciplinary
Cheng-Ping Yu, Yijie Tang, Lide Cha, Sergey Milikisiyants, Tatyana I. Smirnova, Alex I. Smirnov, Yisong Guo, Wei-chen Chang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Environmental Sciences
Chien-Yu Lin, Kuo-Sen Tseng, Jui-Ming Liu, Heng-Chang Chuang, Chi-Hone Lien, Yi-Chih Chen, Chun-Ying Lai, Cheng-Ping Yu, Ren-Jun Hsu
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Oncology
Jui-Ming Liu, Cheng-Ping Yu, Heng-Chang Chuang, Chun-Te Wu, Ren-Jun Hsu
PROSTATE CANCER AND PROSTATIC DISEASES
(2019)
Article
Oncology
Jean Ching-Yuan Fann, King-Jen Chang, Chen-Yang Hsu, Amy Ming-Fang Yen, Cheng-Ping Yu, Sam Li-Sheng Chen, Wen-Hung Kuo, Laszlo Tabar, Hsiu-Hsi Chen
Article
Oncology
Chun-Jung Cho, Ching-Wei Yang, Chia-Lun Wu, Jar-Yi Ho, Cheng-Ping Yu, Sheng-Tang Wu, Dah-Shyong Yu
Article
Cell Biology
Cheng-Shuo Huang, Jar-Yi Ho, Jung-Hwa Chiang, Cheng-Ping Yu, Dah-Shyong Yu
Article
Medicine, Research & Experimental
Chun-Jung Cho, Cheng-Ping Yu, Chia-Lun Wu, Jar-Yi Ho, Ching-Wei Yang, Dah-Shyong Yu
Summary: The study demonstrated that capsaicin has the strongest synergistic cytotoxic effect with gemcitabine on T24-GCB cells, while quercetin, curcumin, and resveratrol have additive effects. Different phytochemicals have varying mechanisms when combined with gemcitabine for the treatment of bladder cancer.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Article
Oncology
Ying-Si Wu, Jar-Yi Ho, Cheng-Ping Yu, Chun-Jung Cho, Chia-Lun Wu, Cheng-Shuo Huang, Hong-Wei Gao, Dah-Shyong Yu
Summary: The study demonstrated that TGF-beta/Smad-induced EMT contributes to GCB resistance in bladder cancer by reducing GCB influx, and elucidated the novel mechanisms of ellagic acid-mediated inhibition of TGF-beta/Smad-induced EMT to overcome GCB resistance. The findings suggest further investigation of ellagic acid as an effective therapeutic adjuvant agent for overcoming GCB resistance in bladder cancer.
Article
Oncology
Cheng-Shuo Huang, Chen-Hua Tsai, Cheng-Ping Yu, Ying-Si Wu, Ming-Fong Yee, Jar-Yi Ho, Dah-Shyong Yu
Summary: This study demonstrates that LINC02470 plays a crucial role in promoting TGF-beta-induced EMT through the miR-143-3p/SMAD3 axis, thus aggravating bladder cancer progression. The findings suggest that LINC02470 could be a potential prognostic marker for bladder cancer.
Article
Medicine, General & Internal
Chien-Peng Huang, Ming-Shen Dai, Chien-Chang Kao, Wen-Chiuan Tsai, Cheng-Ping Yu
Summary: Oncocytic adrenal cortical neoplasms, including oncocytoma, oncocytic neoplasms of uncertain malignant potential, and oncocytic adrenal cortical carcinomas, are rare cases. We present a case of oncocytic adrenal cortical carcinoma with scalp metastasis, which is the first reported case of its kind. Our case highlights the limitations of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) in determining the malignant potential of oncocytic adrenal cortical neoplasms.
MEDICINA-LITHUANIA
(2022)
Article
Oncology
Dah-Shyong Yu, Yi-Ting Chen, Chia-Lun Wu, Cheng-Ping Yu
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2017)