Review
Immunology
Minghui Zheng, Jing Li, Weizhen Fang, Ling Luo, Rui Ding, Hua Zeng, Hong Luo, Xianghua Lin, Chaohui Duan
Summary: A meta-analysis explored the association between specific polymorphisms in the IFN-γ and TNF-α genes and the incidence of LC. The results showed that rs361525 is associated with LC in alcoholic liver cirrhosis and HBV-related cirrhosis, while rs2430561 is associated with LC in the Asian population and in the context of HBV-related cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jiebing Gu, Jing Sun, Yingyu Zhang, Xiaoshuang Wang, Lingling Fu, Linfang Li, Di Wang, Xiuting Wang, Le Yu, Xuemei Han
Summary: This meta-analysis found a marginally significant association between the IFNG +874AT genotype and high risk of MS, but no significant association between TNFA and TNFB gene polymorphisms and MS risk. Further studies with larger samples are needed for more conclusive results about the contribution of other polymorphisms to the risk of MS.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Clinical Neurology
Xiao-Yan Chen, Ko Ling Chan, Camilla K. M. Lo, Frederick K. Ho, Wing Cheong Leung, Patrick Ip
Summary: This meta-analysis examined the association between childhood and adulthood victimization and inflammation, highlighting a significant positive correlation. The effect size was found to be small, with childhood victimization showing a stronger effect on inflammation compared to adulthood victimization. Prevention of childhood victimization may be necessary to reduce inflammatory responses.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Multidisciplinary Sciences
Sepehr Sadafi, Ali Ebrahimi, Masoud Sadeghi, Omid Emami Aleagha
Summary: This study examined the relationship between tumor necrosis factor-alpha (TNF-a) polymorphisms and the risk of psoriasis. The results showed that the -238 G/A rs361525 polymorphism and the -857C/T rs1799724 polymorphism were associated with an increased risk of psoriasis. The study recommends future well-designed studies with larger sample sizes to confirm these results.
Article
Chemistry, Medicinal
Ahmed A. H. Abdellatif, Mansour Alsharidah, Osamah Al Rugaie, Hesham M. Tawfeek, Nahla Sameh Tolba
Summary: The study found that silver nanoparticles reduced with ethyl cellulose polymer (AgNPs-EC) have an inhibitory effect on TNF-alpha expression in breast cancer cells, with low cytotoxicity. This suggests the potential use of AgNPs-EC in the development of novel, safe approaches for cancer treatment in the future.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Dermatology
Lijuan Wang, Hongying Zhou
Summary: This meta-analysis revealed significant associations between specific TNF-alpha polymorphisms and psoriasis, especially in high-risk Caucasian and East Asian populations.
Article
Engineering, Chemical
Qiulan Luo, Hui Zhu, Yun Li, Qinghan Wu, Junjun Sun, Fei Zhou
Summary: In this study, it was found that BIRC3 is abundantly expressed in esophageal cancer (ESCA) cells and plays a crucial role in maintaining their survival. The expression of BIRC3 was up-regulated by the proinflammatory cytokines TNF alpha and IL-1 beta through the NF-kappa B signaling pathway. These findings provide potential targets for the prevention and treatment of esophageal cancer.
Article
Clinical Neurology
Nour Hamad, Karem H. Alzoubi, Samer F. Swedan, Omar F. Khabour, Khalid El-Salem
Summary: The study found a significant association between rs1800629 and rs1799724 variants in the TNF alpha gene and migraine in the Jordanian population. The A allele in rs1800629 was associated with a higher risk of migraine in both male and female subjects.
NEUROLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Yinhao Wei, Zhongyi Zhao, Zhonghao Wang, Keyi Zhang, Zhuoyun Tang, Chuanmin Tao
Summary: The study identified associations between IL-1 beta, TNF-alpha gene polymorphisms and HBV infection, with IL-1 beta rs1143634, TNF-alpha rs1799724, and rs1799964 potentially serving as genetic biomarkers in HBV infection.
Article
Endocrinology & Metabolism
Jing Liu, Guang Song, Ge Zhao, Tao Meng
Summary: The meta-analysis found a significant association between TNF-alpha rs1800629 and GDM risk in the Asian population, while no association was observed for rs361525 and rs1799724. Further multi-ethnic and larger sample size studies are needed to confirm these findings.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Baotian Wang, Fan Wang, De Wu, Xiaoyan Xu, Li Yang, Jing Zhu, Jinjing Yuan, Jiulai Tang
Summary: The meta-analysis found an association between blood TNF-alpha levels and the risk of cerebral palsy in children, confirming the correlation between the two. Further investigation is needed to explore the exact relationship between TNF-alpha and cerebral palsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Wei Lin, Chung-Hwan Chen, Meng-Hsing Wu, Fong-Ming Chang, Lin Kang
Summary: This study investigated the association between two promoter polymorphisms in the TNF genes and preeclampsia (PE). It found that the polymorphism at the -308 position in the TNF-a gene promoter region is associated with severe PE in Taiwanese Han populations.
Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Article
Endocrinology & Metabolism
P. Zhu, X. Wu, J. Zhou, K. Wie, Y. Lu
Summary: This meta-analysis suggests that TNF-alpha rs1800629, IL-1A rs1800587, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in overall population. Moreover, TNF-alpha rs1800629 and IL-6 rs1800795 polymorphisms may influence the risk of Graves' disease in Caucasians, while IL-1A rs1800587, IL-1B rs16944, IL-6 rs1800795 and IL-6 rs1800796 polymorphisms may influence the risk of Graves' disease in Asians.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Cristina Maria Sabo, Mohamed Ismaiel, Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Simona Grad, Dan L. L. Dumitrascu
Summary: In this study, the levels of tumor necrosis factor-alpha (TNF-a) in the colon were evaluated in patients with diverticular disease (DD). The results showed no significant difference in mucosal TNF-a levels between symptomatic uncomplicated DD and asymptomatic DD patients. However, TNF-a levels were significantly higher in DD patients compared to irritable bowel syndrome (IBS) patients. These findings suggest that TNF-a may play a key role in the pathogenesis of DD and could be a potential target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Qiuyan Li, Rongwei Guan, Yuandong Qiao, Chang Liu, Ning He, Xuelong Zhang, Xueyuan Jia, Haiming Sun, Jingcui Yu, Lidan Xu
Article
Biochemistry & Molecular Biology
Lei Li, Xiao Li, Xin Huang, Weilai Jiang, Letian Liu, Chunning Hou, Yanqing Yang, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Guolin Li, Haiming Sun, Limin Mao
BIOSCIENCE REPORTS
(2018)
Meeting Abstract
Oncology
Anthony M. Musolf, Haiming Sun, Bilal A. Moiz, Diptasri Mandal, Mariza de Andrade, Colette Gaba, Ping Yang, Yafang Li, Ming You, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson
Article
Genetics & Heredity
Qingguo Jiao, Haiming Sun, Haoya Zhang, Ran Wang, Suting Li, Dan Sun, Xiu-An Yang, Yan Jin
Article
Infectious Diseases
Chang Liu, Yuandong Qiao, Lidan Xu, Jiawei Wu, Qingbu Mei, Xuelong Zhang, Kaili Wang, Qiuyan Li, Xueyuan Jia, Haiming Sun, Jie Wu, Wenjing Sun, Songbin Fu
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Anthony M. Musolf, Winson S. C. Ho, Kyle A. Long, Zhengping Zhuang, Davis P. Argersinger, Haiming Sun, Bilal A. Moiz, Claire L. Simpson, Elena G. Mendelevich, Enver Bogdanov, Joan E. Bailey-Wilson, John D. Heiss
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Cell Biology
Chenlong Li, Hongshan Zheng, Weiliang Hou, Hongbo Bao, Jinsheng Xiong, Wanli Che, Yifei Gu, Haiming Sun, Peng Liang
CELL DEATH & DISEASE
(2019)
Article
Oncology
Anthony M. Musolf, Bilal A. Moiz, Haiming Sun, Claudio W. Pikielny, Yohan Bosse, Diptasri Mandal, Mariza de Andrade, Colette Gaba, Ping Yang, Yafang Li, Ming You, Ramaswamy Govindan, Richard K. Wilson, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Hui Zhao, Ying Guo, Yanan Ma, Yunping Chen, Haiming Sun, Donglin Sun, Nan Wu, Yan Jin
Summary: The study introduced a method to robustly analyze single-cell RNA sequencing data by considering all genes annotated to specific functional modules, achieving reliable function identification and dimensionality reduction while avoiding random disturbance of individual genes.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Electrochemistry
Xiwei Zhuang, Xueqiong Yang, Bo Cao, Haiming Sun, Xiaoyan Lv, Chijia Zeng, Fugang Li, Bin Qu, H. Susan Zhou, Feiyun Cui, Qin Zhou
Summary: The CRISPR/Cas system has gained attention for its gene-editing capabilities. The reported trans-cleavage activity of Cas proteins has increased the system's diagnostic ability. When applied in electrochemical biosensors, the CRISPR/Cas system provides high specificity, low detection limits, and meets point-of-care testing requirements. This review introduces the history, advantages, and applications of EC biosensors based on the CRISPR/Cas system, and proposes future prospects.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Cell Biology
Dongmei Zhang, Yunzhen Zhou, Yanan Ma, Ping Jiang, Hongchao Lv, Sijia Liu, Yu Mu, Chong Zhou, Shan Xiao, Guohua Ji, Peng Liu, Ning Zhang, Donglin Sun, Haiming Sun, Nan Wu, Yan Jin
Summary: In hepatocellular carcinoma (HCC), the overexpression of ribosomal protein L22-like1 (RPL22L1) is associated with malignancy and poor patient survival. RPL22L1 promotes cell proliferation, migration, invasion, and sorafenib resistance through activating ERK and inducing atypical epithelial-to-mesenchymal transition. The use of an ERK inhibitor enhances the efficacy of sorafenib in HCC patients with high RPL22L1 expression.
CELL DEATH DISCOVERY
(2022)
Article
Biotechnology & Applied Microbiology
Xuelong Zhang, Xi Wang, Han Mo, Yuanting Hu, Yi Yang, Xun Yang, Jiawei Wu, Bangquan Liu, Lidan Xu, Haiming Sun, Xueyuan Jia, Ping Wang, Kaili Wang, Wenjing Sun, Songbin Fu, Yuandong Qiao
Summary: The study suggests that NHEJ gene polymorphisms are associated with HIV-1 infection and AIDS progression among MSM in northern China.
Article
Engineering, Environmental
Feiyun Cui, Haiming Sun, Xueqiong Yang, Hang Zhou, Yiqi Wu, Jing Li, Hongxia Li, Jianlei Liu, Chijia Zeng, Bin Qu, Jufan Zhang, Qin Zhou
Summary: Non-enzymatic glucose sensors were developed using Au@CuO or Au@CuO/V2CTx MXene nanocomposites modified on disposable laser-induced graphene (LIG) electrode. Results showed that Au@CuO/LIG had excellent electrocatalytic activity for glucose oxidation, making it preferred for glucose testing. The sensor demonstrated good selectivity, stability, and affordable price, making it suitable for clinical use.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Infectious Diseases
Jiawei Wu, Lidan Xu, Bangquan Liu, Wenjing Sun, Yuanting Hu, Yi Yang, Keer Guo, Xueyuan Jia, Haiming Sun, Jie Wu, Yun Huang, Wei Ji, Songbin Fu, Yuandong Qiao, Xuelong Zhang
Summary: Genetic variants of G2/M checkpoint genes are associated with HIV-1 infection and AIDS progression in a northern Chinese MSM population.
AIDS RESEARCH AND THERAPY
(2023)
Meeting Abstract
Oncology
Anthony Musolf, Haiming Sun, Bilal A. Moiz, Claudio W. Pikielny, Mariza De Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Yafang Li, Ming You, Richard K. Wilson, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Ramaswamy Govindan, Joan E. Bailey-Wilson