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Evidences for association of the CASP8-652 6N del promoter polymorphism with age at diagnosis in familial breast cancer cases

BREAST CANCER RESEARCH AND TREATMENT (2009)

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BREAST CANCER RESEARCH AND TREATMENT
卷 113, 期 3, 页码 607-608

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SPRINGER
DOI: 10.1007/s10549-008-9963-y

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Oncology

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  1. Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom

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Article Oncology

Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores

Daniel R. Barnes, Valentina Silvestri, Goska Leslie, Lesley McGuffog, Joe Dennis, Xin Yang, Julian Adlard, Bjarni A. Agnarsson, Munaza Ahmed, Kristiina Aittomaki, Irene L. Andrulis, Adalgeir Arason, Norbert Arnold, Bernd Auber, Jacopo Azzollini, Judith Balmana, Rosa B. Barkardottir, Daniel Barrowdale, Julian Barwell, Muriel Belotti, Javier Benitez, Pascaline Berthet, Susanne E. Boonen, Ake Borg, Aniko Bozsik, Angela F. Brady, Paul Brennan, Carole Brewer, Joan Brunet, Agostino Bucalo, Saundra S. Buys, Trinidad Caldes, Maria A. Caligo, Ian Campbell, Hayley Cassingham, Lise Lotte Christensen, Giulia Cini, Kathleen B. M. Claes, Jackie Cook, Anna Coppa, Laura Cortesi, Giuseppe Damante, Esther Darder, Rosemarie Davidson, Miguel de la Hoya, Kim De Leeneer, Robin de Putter, Jesus Del Valle, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Alan Donaldson, Jacqueline Eason, Ros Eeles, Christoph Engel, D. Gareth Evans, Lidia Feliubadalo, Florentia Fostira, Megan Frone, Debra Frost, David Gallagher, Andrea Gehrig, Sophie Giraud, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Helen Gregory, Eva Gross, Eric Hahnen, Ute Hamann, Thomas V. O. Hansen, Helen Hanson, Julia Hentschel, Judit Horvath, Louise Izatt, Angel Izquierdo, Paul A. James, Ramunas Janavicius, Uffe Birk Jensen, Oskar Th Johannsson, Esther M. John, Gero Kramer, Lone Kroeldrup, Torben A. Kruse, Charlotte Lautrup, Conxi Lazaro, Fabienne Lesueur, Adria Lopez-Fernandez, Phuong L. Mai, Siranoush Manoukian, Zoltan Matrai, Laura Matricardi, Kara N. Maxwell, Noura Mebirouk, Alfons Meindl, Marco Montagna, Alvaro N. Monteiro, Patrick J. Morrison, Taru A. Muranen, Alex Murray, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Tu Nguyen-Dumont, Dieter Niederacher, Edith Olah, Olufunmilayo Olopade, Domenico Palli, Michael T. Parsons, Inge Sokilde Pedersen, Bernard Peissel, Pedro Perez-Segura, Paolo Peterlongo, Annabeth H. Petersen, Pedro Pinto, Mary E. Porteous, Caroline Pottinger, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Johanna Rantala, Mark Robson, Mark T. Rogers, Karina Ronlund, Andreas Rump, Ana Maria Sanchez de Abajo, Payal D. Shah, Saba Sharif, Lucy E. Side, Christian F. Singer, Zsofia Stadler, Linda Steele, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Alex Teule, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Stefania Tommasi, Angela Toss, Alison H. Trainer, Vishakha Tripathi, Virginia Valentini, Christi J. van Asperen, Marta Venturelli, Alessandra Viel, Joseph Vijai, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Anna Whaite, Ines Zanna, Kenneth Offit, Mads Thomassen, Fergus J. Couch, Rita K. Schmutzler, Jacques Simard, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Laura Ottini

Summary: The study assessed the associations of polygenic risk scores with breast and prostate cancer risks for male BRCA1 and BRCA2 carriers, finding strong associations between the risk scores and the respective cancer risks. The estimated breast cancer odds ratios were larger after adjusting for family history of female relative breast cancer.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2022)

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