Article
Surgery
Keerthini Muthuswamy, Rebecca Fisher, Stella Mavroveli, Fotis Petrou, Sabrina Khawar, Ashik Amlani, George B. Hanna, Dimitri J. Hadjiminas, Paul T. R. Thiruchelvam, Daniel R. Leff
Summary: A simulator has been designed to safely practice and assess axillary lymph node dissection (ALND), and its face, content, and construct validity has been investigated. The study found that the simulator demonstrated construct validity for ALND assessment and could be a useful tool for skills training and assessments.
Article
Oncology
James Sun, Brittany J. Mathias, Christine Laronga, Weihong Sun, Jun-Min Zhou, William J. Fulp, John Kiluk, M. Catherine Lee
Summary: The study found that completion axillary lymph node dissection (CLND) after mastectomy did not significantly reduce recurrence or improve overall survival (OS) in clinically node-negative, sentinel lymph node (SLN)-positive breast cancer patients. However, completion of postmastectomy radiotherapy was associated with improved OS.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Biology
Shawn Sun, Simukayi Mutasa, John Nemer, Mary Sun, Maham Siddique, Elise Desperito, Sachin Jambawalikar, Richard S. Ha
Summary: It is feasible to predict axillary lymph node metastasis from breast cancer ultrasound images using a convolutional neural network, which can potentially aid nodal staging in patients with breast cancer.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Ya Qiu, Xiang Zhang, Zhiyuan Wu, Shiji Wu, Zehong Yang, Dongye Wang, Hongbo Le, Jiaji Mao, Guochao Dai, Xuwei Tian, Renbing Zhou, Jiayi Huang, Lanxin Hu, Jun Shen
Summary: The MRI-clinical-radiomics nomograms developed in this study showed high predictive performance in determining axillary NSLN status in SLN-positive breast cancer patients, reducing overtreatment and optimizing personalized surgical strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ji Young You, Eun Sook Lee, Siew Kuan Lim, Youngmee Kwon, So-Youn Jung
Summary: According to the study, performing sentinel lymph node biopsy (SLNB) without axillary lymph node dissection (ALND) may be a reasonable treatment option for patients with positive lymph nodes after breast cancer surgery. There was no significant difference in the loco-regional recurrence rates between SLNB with ALND and SLNB alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Eline E. F. Verreck, Julia E. C. van Steenhoven, Anne Kuijer, Marissa C. van Maaren, Janine M. Simons, Sabine Siesling, Thijs van Dalen
Summary: A study found that the frequency of ALND in SLN+ breast cancer patients undergoing mastectomy significantly decreased over time, while the frequency of PMRT increased. Factors such as age, tumor subtype, N stage, and hospital type affected the likelihood of patients undergoing ALND.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Julia Caroline Radosa, Erich-Franz Solomayer, Martin Deeken, Peter Minko, Julia Sarah Maria Zimmermann, Askin Canguel Kaya, Marc Philipp Radosa, Lisa Stotz, Sarah Huwer, Carolin Mueller, Maria Margarete Karsten, Gudrun Wagenpfeil, Christoph Georg Radosa
Summary: This study aimed to evaluate the accuracy of preoperative sonographic staging in predicting axillary disease in early-stage breast cancer patients, and identify factors associated with high accuracy. The results showed that preoperative ultrasound had high accuracy in predicting limited axillary disease for patients with one metastatic lymph node, but lower accuracy for patients with two suspicious nodes. Additionally, the number of suspicious lymph nodes was found to be inversely associated with the accuracy of prediction.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xi'E Hu, Jingyi Xue, Shujia Peng, Ping Yang, Zhenyu Yang, Lin Yang, Yanming Dong, Lijuan Yuan, Ting Wang, Guoqiang Bao
Summary: This study developed a nomogram to preoperatively predict the risk of SLN metastasis in breast cancer patients, demonstrating high predictive performance and clinical usefulness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sophie H. H. Chung, Susanna W. L. de Geus, Grant Shewmaker, Kelsey S. S. Romatoski, Frederick T. T. Drake, Naomi Y. Y. Ko, Andrea L. L. Merrill, Ariel E. E. Hirsch, Jennifer F. F. Tseng, Teviah E. E. Sachs, Michael R. R. Cassidy
Summary: This study compared the survival outcomes of men with positive sentinel lymph nodes after either sentinel lymph node biopsy (SLNB) alone or complete axillary dissection (ALND) in breast cancer. The results showed that ALND was associated with superior survival compared to SLNB alone in early-stage male breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yu Liu, Ying Wang, Senwen Feng, Zeyan Xu, Mengxia Yao, Xiaomei Huang, Pinxiong Li, Lei Wu, Chunling Liu, Xin Chen, Changhong Liang, Zaiyi Liu
Summary: The study aimed to determine whether post-NAT axillary ultrasound (AUS) could reduce the false-negative rate (FNR) of sentinel lymph node biopsy (SLNB) and improve patient selection for SLNB. The results showed that using negative post-NAT AUS could decrease the FNR of SLNB, especially in certain subgroups.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Xunxi Lu, Mengting He, Luoting Yu, Zongchao Gou
Summary: This cohort study found that receiving surgical axillary staging was associated with better survival for patients with ipsilateral breast tumor recurrence, and repeat sentinel lymph node biopsy had a similar long-term survival outcome as axillary lymph node dissection. Therefore, repeat sentinel lymph node biopsy may be considered for surgical axillary staging in patients with ipsilateral breast tumor recurrence after lumpectomy and initial sentinel lymph node biopsy.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Editorial Material
Dermatology
Sophie Stoneham, Bronwyn Hughes, Avi Agrawal
Summary: This is a case report of a 62-year-old woman with cord-like tethering to her left breast after axillary sentinel lymph node biopsy for a 1.0-mm melanoma. The presentation, investigations, and the likely underdiagnosed nature of this condition are discussed.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)