期刊
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 47, 期 4, 页码 817-823出版社
UNIV SAO PAULO, CONJUNTO QUIMICAS
DOI: 10.1590/S1984-82502011000400019
关键词
Nasal drug/delivery systems; Midazolam hydrochloride/bioavailability; Linum usitatissimum L./pharmacognosy; Linum usitatissimum L./mucoadhesive agent; Natural mucilage/nasal gel
Nasal drug delivery systems prepared from natural materials are gaining importance in the field of pharmaceutical technology. Mucilage isolated from Linum usitatissimum L. (LUM) seeds was reported to be an effective natural mucoadhesive agent. The present study deals with a comparison of various characteristics of nasal gels containing midazolam hydrochloride (HCl) prepared from mucoadhesive agent extracted from Linum usitatissimum L. seeds and synthetic polymers like HPMC and Carbopol 934P in terms of texture profile analysis, mucoadhesive strength, and in vivo drug absorption profiles. It was observed that gels formulated with the natural mucilage showed better results than the synthetic gels in all aspects like hardness, adhesiveness, cohesiveness and mucoadhesive strength. The absolute bioavailability of midazolam hydrochloride from the natural gel was 97.55% whereas that of synthetic gels was 57.33% and 76.81% respectively.
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