Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

(2015) Genevieve L. Weber et al.   Oncotarget

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

(2011) Stephen Jamieson et al.   BIOCHEMICAL JOURNAL

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

(2011) Meiju Ji et al.   BMC CANCER

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes

(2011) Edwin Choy et al.   CANCER

A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas

(2011) Meghan L. Rudd et al.   CLINICAL CANCER RESEARCH

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma

(2011) Sohei Yamamoto et al.   JOURNAL OF PATHOLOGY

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms

(2011) Pixu Liu et al.   NATURE MEDICINE

RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells

(2011) Xin-Ke Zhou   WORLD JOURNAL OF GASTROENTEROLOGY

Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers

(2010) Yoshifumi Baba et al.   CANCER

Identification of Novel Gene Amplifications in Breast Cancer and Coexistence of Gene Amplification with an Activating Mutation of PIK3CA

(2009) M. Kadota et al.   CANCER RESEARCH

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Mutational Analyses of Multiple Oncogenic Pathways in Intraductal Papillary Mucinous Neoplasms of the Pancreas

(2009) Frank Schönleben et al.   PANCREAS

Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis

(2008) Martha Lilia Tena-Suck et al.   Annals of Diagnostic Pathology

PIK3CA Mutations and BRCA1 Expression in Breast Cancer: Potential Biomarkers for Chemoresistance

(2008) Mariacarmela Santarpia et al.   CANCER INVESTIGATION

Targeting the PI3K p110  Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration

(2008) A. S. Guerreiro et al.   CLINICAL CANCER RESEARCH

Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors

(2008) Yong Lin et al.   ENDOCRINE-RELATED CANCER