Article
Infectious Diseases
Jee Hong Kim, Yun Young Cho, Ji Young Choi, Yu Mi Wi, Kwan Soo Ko
Summary: This study investigated the characteristics of KPC-2-producing Klebsiella pneumoniae isolates from a hospital in South Korea. It identified two main clones, ST11 and ST307, with different resistance profiles and virulence levels. Continuous monitoring of these clones, which show different characteristics including resistance and virulence, is necessary.
Article
Infectious Diseases
Carolina Sabenca, Eliana Costa, Sara Sousa, Lillian Barros, Ana Oliveira, Sonia Ramos, Gilberto Igrejas, Carmen Torres, Patricia Poeta
Summary: The emergence of Klebsiella pneumoniae strains producing ESBL and KPC has become a major public health concern. The ability of these strains to form biofilms is worrisome as it can facilitate the spread of antibiotic resistance and prolong infections in healthcare facilities.
Article
Infectious Diseases
Rita Elias, Anton Spadar, Antoni P. A. Hendrickx, Remy A. Bonnin, Laurent Dortet, Margarida Pinto, Jody E. Phelan, Isabel Portugal, Susana Campino, Gabriela Jorge da Silva, Taane G. Clark, Aida Duarte, Joao Perdigao
Summary: This study characterized the genomic diversity and international dissemination of CRKP strains from tertiary care hospitals in Lisbon, Portugal. Two genomic clusters, ST13/GC1 and ST17/GC2, were identified. Additionally, an emerging OXA-181/ST17-producing strain in Portugal and the ongoing international dissemination of a KPC-3/ST13-producing clone were highlighted.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Oumar Ouchar Mahamat, Marie Kempf, Manon Lounnas, Abelsalam Tidjani, Mallorie Hide, Julio A. Benavides, Christian Carriere, Anne-Laure Banuls, Helene Jean-Pierre, Abdoul-Salam Ouedraogo, Yann Dumont, Sylvain Godreuil
Summary: The study investigated the knowledge gaps on ESBL-E and CPE in West and Central Africa using a 'One Health' approach, revealing major gaps in understanding ESBL and CPE in animals and the environment. The results emphasize the urgent need to improve active surveillance programs in each country and to support antimicrobial stewardship.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Immunology
Pan Fu, Xinpeng Luo, Jun Shen, Leiyan He, Hua Rong, Chunling Li, Saige Chen, Lei Zhang, Aimin Wang, Chuanqing Wang
Summary: This study investigated carbapenemase-producing Enterobacteriaceae (CPE) strains isolated from children in Shanghai, China from 2016 to 2021. The results showed that NDM was the primary carbapenemase in children (67.6%), followed by KPC (26.4%), IMP (5.3%), and OXA-48 (0.6%). NDM-Kpn posed the most serious threat to infants, especially neonates, and the high-risk clone ST11 KPC-Kpn should be continuously monitored in children.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Engineering, Multidisciplinary
Beiwen Zheng, Hao Xu, Lihua Guo, Xiao Yu, Jinru Ji, Chaoqun Ying, Yunbo Chen, Ping Shen, Huiming Han, Chen Huang, Shuntian Zhang, Tao Lv, Yonghong Xiao
Summary: This study investigates the population structure and genetic characteristics of carbapenemase-producing Enterobacteriaceae (CPE) isolates among bloodstream infections (BSIs) in China. The research reveals a high prevalence of ESBLs and wide dissemination of CPE in BSIs, with the clonal spread of KPC2-producing K. pneumoniae ST11 and NDM-5-producing E. coli ST167 being of particular concern.
Article
Infectious Diseases
Hyeonji Seo, Hwa Jung Kim, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Jiwon Jung
Summary: This study compared clinical outcomes between patients with KPC-producing Enterobacterales and those with NDM-producing Enterobacterales, finding that 30-day mortality was higher and infection development more frequent in the former group. Factors contributing to mortality included solid cancer, solid organ transplant, high APACHE II score, previous carbapenem use within 3 months, and site of infection.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Forough Babazadeh, Roghayeh Teimourpour, Mohsen Arzanlou, Hadi Peeridogaheh, Mehdi Yousefipour, Jafar MohammadShahi
Summary: The objective of this study was to evaluate the phenotypic and molecular characterization of ESBL/AmpC- and carbapenemase-producing K. pneumoniae isolates in Iran. The results showed that K. pneumoniae isolates had high resistance rates to cefazolin and cefotaxime, while meropenem and amikacin exhibited high sensitivity rates. The most frequent carbapenemase-encoding genes were bla(OXA-48) and bla(IMP), while bla(KPC) and bla(GTM) were not detected. Among the ESBL and AmpC beta-lactamase-encoding genes, bla(TEM) had the highest frequency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Microbiology
Marija Kvesic, Ivica Samanic, Anita Novak, Zeljana Fredotovic, Mia Dzelalija, Juraj Kamenjarin, Ivana Goic Barisic, Marija Tonkic, Ana Maravic
Summary: This study investigated the emergence of carbapenemase-producing Enterobacteriaceae in coastal waters of the central Adriatic Sea in Croatia, revealing the presence of extensively drug resistant and colistin-resistant isolates. Whole genome sequencing identified a variety of resistance and virulence genes, as well as the co-occurrence of carbapenemase genes bla(KPC-2) and bla(OXA-48) in certain strains, raising concerns about the spread of these infectious threats in the marine environment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Paolo Gaibani, Federica Bovo, Linda Bussini, Tiziana Lazzarotto, Stefano Amadesi, Michele Bartoletti, Pierlugi Viale, Simone Ambretti
Summary: In this study, the in vivo evolution of resistance to imipenem/cilastatin/relebactam in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) strains from a patient treated with different ceftazidime/avibactam-based therapies was described. The rapid development of mutations and adaptability of the KPC-Kp genome highlight the potential threat of these bacteria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Vincent H. Tam, Paul R. Merlau, Cole S. Hudson, Ellen G. Kline, Brianna M. Eales, James Smith, Amelia K. Sofjan, Ryan K. Shields
Summary: This study used a novel framework to determine the optimal drug exposure to suppress carbapenemase-producing bacteria. The results showed that ceftazidime/avibactam 2.5 g every 12 hours achieved the best outcome.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Food Science & Technology
Alberto Pintor-Cora, Laura Alvaro-Llorente, Andres Otero, Jose M. Rodriguez-Calleja, Jesus A. Santos
Summary: Fresh vegetables are a potential important transmission route for ESBL-producing Enterobacteriaceae, with a contamination rate of up to 82.9%. A total of 15 ESBL-producing isolates were obtained, including 5 multi-drug resistant Serratia fonticola, which can be an environmental reservoir of antibiotic-resistance genes.
Article
Infectious Diseases
Mihret Tilahun
Summary: Antibiotic resistance is a global issue, and this study assessed the prevalence of multidrug-resistant bacteria among surgical patients in northeast Ethiopia. The findings revealed a high prevalence of resistant strains and highlighted the need for enhanced infection prevention and control measures.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Tom J. B. de Man, Anna Q. Yaffee, Wenming Zhu, Dhwani Batra, Efe Alyanak, Lori A. Rowe, Gillian McAllister, Heather Moulton-Meissner, Sandra Boyd, Andrea Flinchum, Rachel B. Slayton, Steven Hancock, Maroya Spalding Walters, Alison Laufer Halpin, James Kamile Rasheed, Judith Noble-Wang, Alexander J. Kallen, Brandi M. Limbago
Summary: This investigation identified the largest known outbreak of VIM-producing CRE in the United States, showcasing evidence of in-hospital plasmid transmission and environmental contamination.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yo Sugawara, Hideharu Hagiya, Yukihiro Akeda, Dan Takeuchi, Noriko Sakamoto, Yuki Matsumoto, Daisuke Motooka, Isao Nishi, Kazunori Tomono, Shigeyuki Hamada
Summary: The study revealed the presence of carbapenemase-producing Enterobacterales (CPE) in healthy residents of Yangon, some of which were related to strains isolated from retail food and clinical settings in the area. This indicates the potential transmission of CPE from clinical and food sources to healthy individuals in the community.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Letter
Infectious Diseases
Liliana Sanchez, Salim Mattar, Derly Rodriguez, Vaneza Tique, Islay Rodriguez
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Public, Environmental & Occupational Health
Carlos H. Gomez-Quintero, Alvaro A. Faccini-Martinez, Carlos A. Botero-Garcia, Marcela Lozano, Liliana Sanchez-Lerma, Jorge Miranda, Salim Mattar, Marylin Hidalgo
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2017)
Article
Infectious Diseases
Pedro Martinez, Denisse Garzon, Salim Mattar
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2012)
Article
Microbiology
Pedro Martinez, Salim Mattar
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2012)
Article
Oncology
P. Espinal, U. Garza-Ramos, F. Reyna, T. Rojas-Moreno, A. Sanchez-Perez, B. Carrillo, P. Martinez, S. Mattar, J. Silva-Sanchez
JOURNAL OF CHEMOTHERAPY
(2010)
Review
Agriculture, Dairy & Animal Science
Liliana Sanchez L, Salim Mattar, Marco Gonzalez T
REVISTA MVZ CORDOBA
(2009)
