Article
Infectious Diseases
Katie A. Parsels, Keri A. Mastro, Jeffrey M. Steele, Stephen J. Thomas, Wesley D. Kufel
Summary: Cefiderocol is a novel siderophore cephalosporin that has shown activity against clinically relevant MDR Gram-negative bacteria. FDA-approved indications include complicated urinary tract infections and hospital-acquired bacterial pneumonia. Clinical trials have demonstrated non-inferiority to standard treatments, but higher all-cause mortality was observed in certain cases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Bogiel, Dagmara Depka, Mateusz Rzepka, Agnieszka Mikucka
Summary: This study assessed the susceptibility and virulence factor gene frequency of clinical P. aeruginosa strains causing bloodstream infections. The results showed that these strains were resistant to multiple antibiotics and had diverse compositions of virulence factor genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Weijun Xiu, Lili Ren, Huayu Xiao, Yue Zhang, Dou Wang, Kaili Yang, Siyu Wang, Lihui Yuwen, Xiao Li, Heng Dong, Qiang Li, Yongbin Mou, Yuqian Zhang, Zhaowei Yin, Bin Liang, Yu Gao, Lianhui Wang
Summary: An ultrasound-responsive catalytic micro-bubble is developed to combat chronic lung infections caused by Pseudomonas aeruginosa biofilms. These microbubbles physically disrupt the biofilm structure and enhance the penetration of nanoparticles and antibiotics. The nanoparticles chemically degrade the biofilm matrix and kill bacteria, while also activating the immune response. This strategy efficiently treats chronic lung infections by combining physical/chemical/antibiotic biofilm elimination and immune activation.
Article
Immunology
Hangbin Hu, Yan Zhang, Piaopiao Zhang, Jie Wang, Qing Yuan, Weixiao Shi, Sheng Zhang, Haiting Feng, Yunbo Chen, Meihong Yu, Hongchao Chen, Yan Jiang, Qing Yang, Tingting Qu
Summary: The study found that KPC-producing CRPA belonging to Sequence Type 463 had a significant impact on bloodstream infections in East China, with a higher mortality rate and resistance to antimicrobials compared to non-ST463 strains. The ST463 CRPA clone showed a high virulence in a larvae model and harbored the bla(KPC) and exoU/exoS genes, indicating a potential new threat in clinical settings. Surveillance of this high-risk clone should be strengthened in China and globally in the future.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Lorenz Leitner, Aleksandre Ujmajuridze, Nina Chanishvili, Marina Goderdzishvili, Irina Chkonia, Sophia Rigvava, Archil Chkhotua, Giorgi Changashvili, Shawna McCallin, Marc P. Schneider, Martina D. Liechti, Ulrich Mehnert, Lucas M. Bachmann, Wilbert Sybesma, Thomas M. Kessler
Summary: This study aimed to determine the effectiveness of intravesical bacteriophage therapy in treating UTIs. Findings showed that bacteriophage therapy was non-inferior to standard antibiotic treatment, but not superior to placebo bladder irrigation in terms of efficacy or safety. The safety profile of bacteriophages appears to be favorable, suggesting potential for further large-scale clinical studies on their role in UTI treatment.
LANCET INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study investigates the effectiveness of a biomimetic nanotoxoid vaccine in protecting immunodeficient animals from Pseudomonas aeruginosa infection. The nanotoxoids utilize a macrophage membrane coating to sequester and present bacterial virulence factors, providing rapid and long-lasting immunity. The nanovaccine can be administered through multiple routes and effectively protects against lethal infections in pneumonia and septicemia models.
Article
Multidisciplinary Sciences
Thomas F. Durand-Reville, Alita A. Miller, John P. O'Donnell, Xiaoyun Wu, Mark A. Sylvester, Satenig Guler, Ramkumar Iyer, Adam B. Shapiro, Nicole M. Carter, Camilo Velez-Vega, Samir H. Moussa, Sarah M. McLeod, April Chen, Angela M. Tanudra, Jing Zhang, Janelle Comita-Prevoir, Jan A. Romero, Hoan Huynh, Andrew D. Ferguson, Peter S. Horanyi, Stephen J. Mayclin, Henry S. Heine, George L. Drusano, Jason E. Cummings, Richard A. Slayden, Ruben A. Tommasi
Summary: The study presents a rational design strategy for developing new antibiotics to combat infections caused by drug-resistant Gram-negative pathogens. The inhibitors are able to overcome multiple mechanisms of resistance and show potential clinical efficacy against superbugs.
Article
Virology
Elisabed Zaldastanishvili, Lika Leshkasheli, Mariam Dadiani, Lia Nadareishvili, Lia Askilashvili, Nino Kvatadze, Marina Goderdzishvili, Mzia Kutateladze, Nana Balarjishvili
Summary: This retrospective study focused on three patients who underwent phage therapy at EPTC in Georgia, revealing that some pathogens persisted through phage therapy, indicating potential adaptation strategies.
Review
Immunology
Pamella Constantino-Teles, Albane Jouault, Lhousseine Touqui, Alessandra Mattos Saliba
Summary: Pseudomonas aeruginosa, an opportunistic pathogen, causes respiratory infections by utilizing various virulence factors, such as bacterial lipids and enzymes, and by interacting with host lipids. These mechanisms play important roles in the establishment and persistence of P. aeruginosa in the lungs, as well as in modulating host immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Roberto Rosales-Reyes, Silvia Yalid Vargas-Roldan, Jose Luis Lezana-Fernandez, Jose Ignacio Santos-Preciado
Summary: Cystic fibrosis is a genetic disease that affects the respiratory and digestive systems, causing chronic lung infections and breathing difficulties. Mutations in the CFTR gene lead to imbalanced intracellular water content, resulting in sticky mucus and bacterial infections that ultimately affect lung function.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Infectious Diseases
Dana Holger, Razieh Kebriaei, Taylor Morrisette, Katherine Lev, Jose Alexander, Michael Rybak
Summary: Pseudomonas aeruginosa is a common pathogen causing healthcare-associated diseases and is highly resistant to many antibiotics, posing challenges in treatment. Bacteriophages, as viruses targeting and infecting bacterial cells, offer promise as an alternative therapy for multidrug-resistant P. aeruginosa infections. Further studies on phage pharmacokinetics and pharmacodynamics are needed to guide successful phage therapy for these infections.
Review
Microbiology
Paulina Paprocka, Bonita Durnas, Angelika Mankowska, Grzegorz Krol, Tomasz Wollny, Robert Bucki
Summary: Pseudomonas aeruginosa is a common opportunistic pathogen in cancer patients, with high antibiotic resistance and adaptability. It causes infections by producing virulence factors and survives and spreads in hospital environments. Treating infections caused by this microorganism is challenging and requires preventive measures.
Article
Biophysics
Wing-Hin Lee, Ramin Rohanizadeh, Ching-Yee Loo
Summary: This study developed a novel bioactive bone substitute with improved anti-biofilm activity by functionalizing with curcumin, which effectively inhibits biofilm formation and controls viable planktonic cells. Curcumin was successfully incorporated onto HA and sustainably released over 14 days, showing stronger anti-biofilm effect against Staphylococcus aureus. The curcumin-loaded HA composite could be an alternative antimicrobial agent to control the risk of infections in postsurgical implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Medicine, General & Internal
Mazen A. Sid Ahmed, Jemal M. Hamid, Ahmed A. Husain, Hamad Abdel Hadi, Sini Skariah, Ali A. Sultan, Emad Bashir Ibrahim, Abdul Latif Al Khal, Bo Soderquist, Jana Jass, Ali S. Omrani
Summary: Bloodstream infections caused by multidrug-resistant Pseudomonas aeruginosa in Qatar are relatively uncommon but highly resistant, with colistin being the only consistent effective treatment. Typical risk factors for MDR infections were prevalent in the study population, and clinical outcomes were generally unfavorable.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Sisi Zhen, Yuanqi Zhao, Zhangjie Chen, Tingting Zhang, Jieru Wang, Erlie Jiang, Fengkui Zhang, Yingchang Mi, Xiaofan Zhu, Mingzhe Han, Zhijian Xiao, Jianxiang Wang, Sizhou Feng
Summary: This study aimed to investigate the clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia and identify risk factors, as well as compare the efficacy of traditional and novel antibiotic regimens. The results showed that the 30-day mortality rate for CRPA bacteremia in hematological patients was 21.0%. Neutropenia >7 days after bloodstream infections, higher Pitt bacteremia score, higher Charlson comorbidity index, and bacteremia due to multidrug-resistant Pseudomonas aeruginosa were identified as independent risk factors of 30-day mortality. Furthermore, Ceftazidime-avibactam-based regimens were found to be associated with lower mortality in CRPA and multidrug-resistant Pseudomonas aeruginosa bacteremia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)