期刊
BRAZILIAN JOURNAL OF BIOLOGY
卷 68, 期 2, 页码 447-452出版社
INT INST ECOLOGY
DOI: 10.1590/S1519-69842008000200031
关键词
Down syndrome; trisomy; HSA21; gene-expression analysis
类别
Even though the molecular mechanisms underlying the Down syndrome (DS) phenotypes remain obscure, the characterization of the genes and conserved non-genic sequences of HSA21 together with large-scale gene expression studies in DS tissues are enhancing our understanding of this complex disorder. Also, mouse models of DS provide invaluable tools to correlate genes or chromosome segments to specific phenotypes. Here we discuss the possible contribution of HSA21 genes to DS and data from global gene expression studies of trisomic samples.
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