期刊
BRAIN TOPOGRAPHY
卷 26, 期 3, 页码 363-377出版社
SPRINGER
DOI: 10.1007/s10548-012-0267-5
关键词
Functional MRI (fMRI); BOLD; Resting-state fMRI (rs-fMRI); Functional connectivity; Anesthesia; Animal models; Neural origin
资金
- NIH [NS041262, NS041262S1, NS057560, NS070839, P41 RR08079, P41 EB015894, P30NS057091, P30NS076408]
- Keck Foundation
Spatiotemporal correlations of spontaneous blood oxygenation level dependent (BOLD) signals measured in the resting brain have been found to imply many resting-state coherent networks under both awake/conscious and anesthetized/unconscious conditions. To understand the resting-state brain networks in the unconscious state, spontaneous BOLD signals from the rat sensorimotor cortex were studied across a wide range of anesthesia levels induced by isoflurane. Distinct resting-state networks covering functionally specific sub-regions of the sensorimotor system were observed under light anesthesia with 1.0 % isoflurane; however, they gradually merged into a highly synchronized and spatially less-specific network under deep anesthesia with 1.8 % isoflurane. The EEG power correlations recorded using three electrodes from a separate group of rats showed similar dependency on anesthesia depth, suggesting the neural origin of the change in functional connectivity specificity. The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states.
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