Review
Clinical Neurology
Mangor Pedersen, David F. Abbott, Graeme D. Jackson
Summary: Magnetoencephalography with optically pumped magnometers (OPM-MEG) is a wearable system that can record neuronal activity with high temporal and spatial resolution. Compared to conventional techniques, OPM-MEG has more advantages and shows potential in epilepsy surgery evaluation.
Review
Neurosciences
Guiomar Niso, Rotem Botvinik-Nezer, Stefan Appelhoff, Alejandro De la Vega, Oscar Esteban, Joset A. Etzel, Karolina Finc, Melanie Ganz, Remi Gau, Yaroslav O. Halchenko, Peer Herholz, Agah Karakuzu, David B. Keator, Christopher J. Markiewicz, Camille Maumet, Cyril R. Pernet, Franco Pestilli, Nazek Queder, Tina Schmitt, Weronika Sojka, Adina S. Wagner, Kirstie J. Whitaker, Jochem W. Rieger
Summary: The empirical observations show that the adoption rate of open practices in research labs is still in its infancy, despite overwhelming evidence of its necessity and benefits. Researchers and institutions can benefit from community-developed resources to support collaborative and reproducible neuroimaging practices throughout the research cycle.
Article
Neurosciences
Marinho A. Lopes, Jiaxiang Zhang, Dominik Krzeminski, Khalid Hamandi, Qi Chen, Lorenzo Livi, Naoki Masuda
Summary: Brain network dynamics are crucial for brain function and dysfunction, and a new framework using recurrence analysis has been proposed to assess the dynamics of brain networks. The recurrence of dFNs may serve as a biomarker for epilepsy, and recurrence analysis can also help detect seizures and inform neurostimulation strategies. This framework can be applied not only to epilepsy but also to understand dFNs in healthy brain function and other neurological disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Daria Kleeva, Gurgen Soghoyan, Ilia Komoltsev, Mikhail Sinkin, Alexei Ossadtchi
Summary: This study proposes a novel biomimetic approach for automatic spike detection based on fast parametric curve matching (FPCM). Results from simulations show the robustness and high receiver operating characteristic AUC values of the FPCM method compared to conventional approaches. The FPCM technique demonstrates reliable detection of interictal events and localization of epileptogenic zones in real MEG and EEG data from human patients and rat ECoG data.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Marinho A. Lopes, Dominik Krzeminski, Khalid Hamandi, Krish D. Singh, Naoki Masuda, John R. Terry, Jiaxiang Zhang
Summary: The study investigated the applicability of the BNI framework to resting-state MEG in patients with JME, finding that patients with JME had a higher propensity to generate seizures compared to healthy controls. The BNI framework was effective in differentiating between epilepsy patients and healthy controls.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Clinical Neurology
Miao Cao, Simon J. Vogrin, Andre D. H. Peterson, William Woods, Mark J. Cook, Chris Plummer
Summary: More informative quantitative techniques are urgently needed to assess strategies for epilepsy surgery objectively and non-invasively. Recent advances in network analysis and dynamical network modeling provide a novel and data-driven approach for a more objective assessment of the epileptogenic zone (EZ). However, further research is required to validate the effectiveness of these methods when applied to non-invasive neuroimaging data and neurophysiological data.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
S. Franceschetti, E. Visani, D. Rossi Sebastiano, D. Duran, T. Granata, R. Solazzi, G. Varotto, L. Canafoglia, F. Panzica
Summary: The study found that Perampanel can reduce the severity of action myoclonus by decreasing cortico-muscular coherence and restoring the leadership of cortical regions. This highlights mechanisms suitable for treating myoclonus and emphasizes the role of reduced local synchronization and better control of distant synaptic effects.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Johannes T. Reiter, Bastian David, Selma Enders, Conrad C. Prillwitz, Tobias Bauer, Deniz Atalay, Anna Tietze, Angela M. Kaindl, Vera Keil, Alexander Radbruch, Bernd Weber, Albert J. Becker, Christian E. Elger, Rainer Surges, Theodor Rueber
Summary: Using MRI and diffusion tensor imaging, this study found bilateral cerebellar atrophy and predominantly ipsilesional mesencephalic atrophy in patients with RE. Morphometric asymmetry indices showed varying patterns of asymmetry, with strong correlation between cerebellar morphometry and FLAIR intensity asymmetry. Spatial independent component analysis revealed bilateral and ipsi/contralesional atrophy components in patients with RE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Rodney Ogwang, Albert Ningwa, Pamela Akun, Paul Bangirana, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro
Summary: Research in northern Uganda shows that epilepsies associated with Onchocerca may have a broader clinical spectrum and brain imaging features, such as focal onset tonic-clonic seizures, cortical and cerebellar atrophy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Odile Feys, Pierre Corvilain, Alec Aeby, Claudine Sculier, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege, Florence Christiaens
Summary: This study compared the effectiveness of cryogenic and on-scalp MEG in detecting and localizing focal interictal epileptiform discharges (IEDs) in children with epilepsy. The results showed that on-scalp MEG had higher IED amplitudes and signal-to-noise ratios compared to cryogenic MEG, and the localization value was similar between the two modalities.
Review
Clinical Neurology
Caihong Ji, Jiajia Zhao, Jianfang Zhang, Kang Wang
Summary: This study reports a novel de novo NUS1 missense variant causing progressive myoclonus epilepsy (PME) and reviews the current literature on NUS1-associated PME. Only five cases of NUS1 variants and PME have been reported so far. The relationship between NUS1 variants and PME is not well-established due to limited cases reported.
NEUROLOGICAL SCIENCES
(2023)
Review
Cell Biology
Claudia Cuccurullo, Pasquale Striano, Antonietta Coppola
Summary: Familial adult myoclonus epilepsy (FAME) is a non-coding repeat expansion disorder that is associated with expansions of pentanucleotide repeats in different genes. FAME is characterized by cortical tremor and myoclonus, with infrequent seizures. The underlying mechanism of FAME is thought to involve decreased sensorimotor cortical inhibition and dysfunction of the cerebellar-thalamic-cortical loop.
Article
Multidisciplinary Sciences
Maryam Honari-Jahromi, Brea Chouinard, Esti Blanco-Elorrieta, Liina Pylkkanen, Alona Fyshe
Summary: Despite the maturity of neuroscience research on composition, the evolution of stored semantic representations during composition remains poorly understood. New decoding techniques have allowed researchers to train models to recognize representations in one context or time-point and assess their accuracy in another. The study found that noun representations were generally more decodable than adjective representations, with nouns maintaining consistency across trials and over time in phrases. Adjective representations, on the other hand, did not show similar consistency across isolated and phrasal contexts.
Article
Neurosciences
Frank Neugebauer, Marios Antonakakis, Kanjana Unnwongse, Yaroslav Parpaley, Joerg Wellmer, Stefan Rampp, Carsten H. Wolters
Summary: MEG and EEG source analysis is frequently used for the presurgical evaluation of pharmacoresistant epilepsy patients. In this study, the authors compared the standard dipole scanning method with two beamformer approaches for the inverse problem and investigated the influence of covariance estimation method and regularization strength on localization performance. They found that beamformer localization is sensitive to the choice of the regularization parameter and that estimation of the covariance matrix with averaged spike data yielded more robust results across modalities.
Article
Neurosciences
Tim M. Tierney, Stephanie Mellor, George C. O'Neill, Ryan C. Timms, Gareth R. Barnes
Summary: This study investigates the interference rejection and spatial sampling properties of multi-axis Optically Pumped Magnetometer (OPM) data, finding that triaxial OPMs have excellent noise rejection properties and can adequately sample the neural space while minimizing cost, weight, and cross-talk.