Article
Neurosciences
Kyna-Anne Conn, Simin Zou, Joyosmita Das, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: In this study, the cognitive symptoms of schizophrenia, including impaired goal-directed action, were found to be associated with altered dopamine signaling in the brain. The differential roles of the dorsomedial and ventral inputs into the striatum in goal-directed action were identified, providing insights into the cognitive problems in schizophrenia.
Article
Neurosciences
Kei Oyama, Yukiko Hori, Koki Mimura, Yuji Nagai, Mark A. G. Eldridge, Richard C. Saunders, Naohisa Miyakawa, Toshiyuki Hirabayashi, Yuki Hori, Ken-ichi Inoue, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Barry J. Richmond, Takafumi Minamimoto
Summary: This study used DREADDs technology to disrupt the interaction between OFC and rmCD in monkeys, and found that it significantly affected the sensitivity to cued reward value for goal-directed behavior. This finding extends the understanding of the physiological basis of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Business
Alexandra Aguirre-Rodriguez, Richard P. Bagozzi, Patricia L. Torres
Summary: Self-regulation involves constraining appetitive desire through rationality-based motivation, directing individuals towards goal-consistent actions. Appetitive desire positively influences goal-directed action intentions by strengthening volitive desire motivation, playing an instrumental rather than detrimental role in motivating reasoned action towards goal pursuit.
PSYCHOLOGY & MARKETING
(2021)
Article
Anatomy & Morphology
Violeta-Maria Caragea, Marta Mendez-Couz, Denise Manahan-Vaughan
Summary: This study confirms the presence of dopamine D1-like and D2-like receptors in the fastigial nucleus (FN) of adult rats, with D1R having a role in goal-directed behavior and motivation for action. Blocking D1R impairs task acquisition and decreases task engagement, while D2R antagonism only affects task performance post-acquisition.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biology
Danilo La Terra, Ann-Sofie Bjerre, Marius Rosier, Rei Masuda, Tomas J. Ryan, Lucy M. Palmer
Summary: The thalamus plays an important role in cortical encoding of complex behavior. The axonal projections from the posteromedial nucleus of the thalamus (POm) to the forepaw area of the primary somatosensory cortex (forepaw S1) increase activity during correct performance but decrease during learning of a new behavior. Furthermore, the POm influences goal-directed behavior.
Article
Neurosciences
Jae-Hyun Kim, Dong-Hyun Ma, Eunji Jung, Ilsong Choi, Seung-Hee Lee
Summary: In this study, Kim et al. found that visual inputs trigger gated feedforward inhibition of ACC neurons, which disinhibits striatal motor neurons and initiates precise responses in mice performing a visual Go/No-go task. The characteristics of ACC neurons can predict response times in mice, and optogenetic activation of visual inputs in the ACC prompts task-relevant actions by suppressing ACC motor neurons and disinhibiting downstream striatal neurons.
NATURE NEUROSCIENCE
(2021)
Article
Psychology, Biological
Shun Fujimaki, Ting Hu, Yutaka Kosaki
Summary: This study examined the recovery of goal-directed and habitual behaviors after extinction in the context of the resurgence effect. The results showed that minimal training led to goal-directed behavior while extended training led to habitual behavior. Furthermore, the findings suggested that reinforcer devaluation could effectively reduce the recurrence of problematic behavior by coupling it with differential-reinforcement-of-alternative-behavior (DRA) treatments.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2023)
Article
Neurosciences
Jeremy Hogeveen, Maria Medalla, Matthew Ainsworth, Juan M. Galeazzi, Colleen A. Hanlon, Farshad Alizadeh Mansouri, Vincent D. Costa
Summary: Understanding the functions of different subregions of primate prefrontal cortex, including the frontopolar cortex, has been a long-standing goal in cognitive neuroscience. This review consolidates knowledge about the anatomy and connectivity of the frontopolar cortex and provides an integrative summary of its function in primates. The authors aim to answer the question of whether the frontopolar cortex contributes to goal-directed cognition and action.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Eike Kofi Buabang, Yannick Boddez, Jan De Houwer, Agnes Moors
Summary: Habitual processes and goal-directed processes may be underestimated in explaining suboptimal behavior. Previous studies overestimated habitual processes due to targeting the wrong outcome in tests, while differences in learning conditions and lack of motivation might lead to behaviors misinterpreted as habitual when they are actually goal-directed.
MOTIVATION SCIENCE
(2021)
Article
Robotics
F. Manzi, M. Ishikawa, C. Di Dio, S. Itakura, T. Kanda, H. Ishiguro, D. Massaro, A. Marchetti
Summary: This study found that 17-month-old infants can anticipate goal-directed actions of both humans and humanoid robots, with no differences in anticipatory gaze behavior between the two agents. Additionally, infants showed a higher attentional preference for the robot's face compared to the human's face.
INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
(2023)
Article
Psychology, Multidisciplinary
Beth Hardie
Summary: The paper introduces a model of Goal-Directed Parental Action to define parental monitoring in adolescent crime, emphasizing the distinction between parental goals, means, and knowledge gathering. This model has the potential to clarify other parenting concepts and processes in the future.
NEW IDEAS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Valentina M. Glueck, Katharina Zwosta, Uta Wolfensteller, Hannes Ruge, Andre Pittig
Summary: The study explores the impact of habitual avoidance behaviors on subsequent goal-directed approaches. It was found that in cases where habitual avoidance conflicted with goal-directed approaches, accuracy was lower, but under explicit guidance, the accuracy differences disappeared while reaction times were slower in habit-incompatible trials.
BEHAVIOUR RESEARCH AND THERAPY
(2021)
Article
Psychology, Clinical
Jaisal T. Merchant, Erin K. Moran, Michael J. Strube, Deanna M. Barch
Summary: This study identified factors related to real-world goal-directed behavior in individuals with schizophrenia, including motivation and pleasure negative symptoms, effort expenditure, and performance on daily functional skills tasks. These findings could help identify targeted treatments for the elusive motivated behavior deficits in this population.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Behavioral Sciences
Eike K. Buabang, Yannick Boddez, Oliver T. Wolf, Agnes Moors
Summary: People are more likely to engage in suboptimal behaviors under stress, such as overeating and short-sighted financial decision-making. Traditional dual-process models suggest that stress impairs goal-directed behavior, leading to reliance on habitual behavior. However, a conceptual replication study found that stressed participants were sensitive to outcome values when the outcomes became aversive, suggesting that suboptimal behavior under stress may not always be habitual.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Marios C. Panayi, Simon Killcross
Summary: Reward predictive cues can selectively motivate instrumental behaviors. Specific satiety devaluation can disrupt the specific Pavlovian-to-instrumental transfer (PIT) effect by habituating the outcome's sensory properties. These findings suggest that specific satiety might disrupt the use of sensory specific outcome representations to guide behavior independent of outcome value.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Mathieu Wolff, Seralynne D. Vann
JOURNAL OF NEUROSCIENCE
(2019)
Article
Psychology, Biological
Fabien Naneix, Sophie C. Pinder, Megan Y. Summers, Renee M. Rouleau, Eric Robinson, Kevin P. Myers, James E. McCutcheon
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Endocrinology & Metabolism
Damien Bonhomme, Serge Alfos, Scott P. Webster, Mathieu Wolff, Veronique Pallet, Katia Touyarot
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Review
Neurosciences
Fabien Naneix, Kate Z. Peters, James E. McCutcheon
Article
Anatomy & Morphology
Etienne Quet, Monique MajchrzakL, Brigitte Cosquer, Thomas Morvan, Mathieu Wolff, Jean-Christophe Cassel, Anne Pereira de Vasconcelos, Aline Stephan
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Neurosciences
Fabien Naneix, Kate Z. Peters, Andrew M. J. Young, James E. McCutcheon
Summary: Protein restriction has varying effects on dopamine pathways in the rat brain, with increased release in the nucleus accumbens during adulthood, decreased release during adolescence, and a frequency-dependent increase in the dorsal striatum when restricted during adolescence. These results highlight the sensitivity and vulnerability of dopamine pathways to protein restriction at different life stages.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Juan-Carlos Cerpa, Alain R. Marchand, Yoan Salafranque, Jean-Remi Pape, Eric J. Kremer, Etienne Coutureau
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Behavioral Sciences
M. Wolff, S. Morceau, R. Folkard, J. Martin-Cortecero, A. Groh
Summary: Adapting to dynamic environments requires tracking multiple signals and integrating communication between sensory and cognitive brain circuits, with thalamic nuclei acting as a crucial bridge in this process. Thalamus plays a key role in linking perception, cognition, and potentially affective processes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Fabien Naneix, Ioannis Bakoyiannis, Marianela Santoyo-Zedillo, Clementine Bosch-Bouju, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira
Summary: Obesity is associated with adverse neurobiological outcomes, particularly in learning and memory. Adolescent exposure to an obesogenic high-fat diet can impair long-term object recognition memory through alterations in ventral hippocampal activity, while enhancing conditioned odor aversion specifically requires amygdala activity. These findings highlight the bidirectional effects of adolescent high-fat diet on hippocampal and amygdala functions.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Giulia Chiacchierini, Fabien Naneix, Kate Zara Peters, John Apergis-Schoute, Eelke Mirthe Simone Snoeren, James Edgar McCutcheon
Summary: The control of protein intake is crucial for biological processes, and this study shows that in rats, protein restriction can lead to increased preference for protein and heightened VTA responses compared to carbohydrates. Prior protein restriction can also induce long-lasting food preference and VTA responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Biological
Giulia Chiacchierini, Fabien Naneix, John Apergis-Schoute, James E. McCutcheon
Summary: Protein restriction increases motivation for protein-rich food, but does not affect motivation for nutritionally-balanced food. The increased motivation for protein-rich food disappears once rats are not in need of protein.
PHYSIOLOGY & BEHAVIOR
(2022)
Review
Neurosciences
Kate Zara Peters, Fabien Naneix
Summary: The prefrontal cortex plays a central role in complex cognitive processes and shows delayed maturation during adolescence. The adolescent brain is highly plastic and vulnerable, which is associated with the emergence of neuropsychiatric disorders. The dopamine and endocannabinoid systems have widespread effects on the development of prefrontal circuits during adolescence.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Biology
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J. Kremer, Mathieu Wolff, Shauna L. Parkes, Etienne Coutureau
Summary: Organisms need to track the relationship between actions and consequences in order to make decisions, which relies on circuits in the brain. There is functional heterogeneity within certain areas of the brain in rodents. Neuromodulatory agents play a crucial role in prefrontal functions and behavioral flexibility.
Article
Behavioral Sciences
Juan-Carlos Cerpa, Etienne Coutureau, Shauna L. Parkes
Summary: The prefrontal cortex is crucial for goal-directed behaviors, while the vlOFC specifically plays a role in adapting to unexpected changes in outcome identities. The vlOFC may be strongly influenced by the noradrenergic system, unlike the mPFC which is primarily modulated by dopamine.
BEHAVIORAL NEUROSCIENCE
(2021)