Article
Clinical Neurology
Asha Kishore, Praveen James, Traian Popa, Arun Thejaus, Parvathy Rajeswari, Gangadhara Sarma, Syam Krishnan, Sabine Meunier
Summary: The study showed that cerebellar stimulation can modulate the plastic response to PAS, and the M1 response of Non-Responders to PAS can be restored after cerebellar stimulation. This suggests that individual responses to plastic modulation may be influenced by the cerebellar neural system.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Na Cao, Atsushi Sasaki, Akiko Yuasa, Milos R. Popovic, Matija Milosevic, Kimitaka Nakazawa
Summary: This study examined the optimal parameters for neuromodulation using combined rTMS and NMES. The results showed that corticospinal excitability was increased after the intervention with concurrent 50 Hz NMES and iTBS, but returned to baseline within 10 minutes. Short-duration concurrent and synchronized stimulation can effectively modulate corticospinal excitability.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Adeel, Bor-Shing Lin, Hung-Chou Chen, Chien-Hung Lai, Jian-Chiun Liou, Chun-Wei Wu, Wing P. Chan, Chih-Wei Peng
Summary: Paired stimulation of the brain and spinal cord can induce motor neuroplasticity in an animal model with spinal cord injury. The effects of stimulation vary depending on the extent and severity of the injury. This study aimed to determine the effects of 3 and 20 minutes of stimulation on an incomplete spinal cord injury rat model. The results showed that specific combinations of stimulation techniques and durations significantly improved electrophysiological and locomotion outcomes in the animal model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yun-Juan Xie, Qing-Chuan Wei, Yi Chen, Ling-Yi Liao, Bao-Jin Li, Hui-Xin Tan, Han-Hong Jiang, Qi-Fan Guo, Qiang Gao
Summary: The study aimed to explore the efficacy of cerebellar intermittent theta burst stimulation (iTBS) on the walking function of stroke patients. It found that applying iTBS over the contralesional cerebellum paired with physical therapy could improve walking performance in patients after stroke, suggesting that cerebellar iTBS intervention may be a noninvasive strategy to promote walking function in these patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Cheng-Ta Li, Chi-Hung Juan, Hui-Ching Lin, Chih-Ming Cheng, Hui-Ting Wu, Bang-Hung Yang, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This study is the first to reveal the underlying molecular mechanisms of the fronto-limbic circuit in individuals with major depressive disorder and demonstrates the differential modulation of neurotransmitter systems by rTMS and iTBS.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Ling-Yi Liao, Yun-Juan Xie, Yi Chen, Qiang Gao
Summary: Intervention with cerebellar iTBS combined with physiotherapy has been shown to enhance balance and motor recovery in poststroke patients, providing a low-cost, rapid, and effective approach for stroke rehabilitation.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Francesca Ginatempo, Nicoletta Manzo, Danny A. Spampinato, Nicola Loi, Francesca Burgio, John C. Rothwell, Franca Deriu
Summary: This study investigated the effects of peripheral nerve and cerebellum paired associative stimulation (cPAS) on plasticity in the cerebellum and cortex. The results showed that cPAS25 had the ability to induce plasticity effects in the cerebellar cortex, resulting in a reduction in cerebellum-brain inhibition (CBI).
Review
Clinical Neurology
Julio C. Hernandez-Pavon, Arantzazu San Agustin, Max C. Wang, Domenica Veniero, Jose L. Pons
Summary: The objective of this article is to systematically review the efficacy of ccPAS in inducing plasticity in humans, with a focus on stimulation parameters and hypotheses of underlying neurophysiology. The review found that ccPAS can modulate brain connectivity depending on the interstimulus intervals, and it has the potential for basic research and potential clinical applications. This article highlights the importance of targeting multiple brain areas to study brain connectivity in the field of transcranial magnetic stimulation.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Behavioral Sciences
Jasmine L. Mirdamadi, Hannah J. Block
Summary: The study found that suppressing activity in the cerebellum and somatosensory cortex affects proprioceptive changes associated with motor skill learning. The cerebellum and somatosensory cortex play important roles in different aspects of proprioceptive changes during skill learning.
Article
Biochemistry & Molecular Biology
Arantzazu San Agustin, Guillermo Asin-Prieto, Juan C. Moreno, Antonio Oliviero, Jose L. Pons
Summary: Transcranial Magnetic Stimulation (TMS) can modulate cortico-spinal excitability and improve motor performance, as shown in a study using a customized video game. This finding highlights the potential of using TMS in neurorehabilitation strategies for complex movements.
Article
Neurosciences
Qing Lin, Yichen Chang, Peng Liu, Jeffery A. Jones, Xi Chen, Danhua Peng, Mingyuan Chen, Chao Wu, Hanjun Liu
Summary: Clinical studies have shown the potential efficacy of neuronavigated continuous theta burst stimulation (c-TBS) over the right cerebellum in modulating abnormal auditory-motor integration for vocal pitch regulation in patients with spinocerebellar ataxia (SCA). The study found that active cerebellar c-TBS led to smaller vocal compensations for pitch perturbations compared to sham stimulation, with parallel modulatory effects observed at the cortical level. Smaller vocal compensations were also predicted by larger amplitudes of cortical P1 and P2 responses.
Article
Clinical Neurology
Jinzhu Rao, Fang Li, Lida Zhong, Jing Wang, Yang Peng, Huiyu Liu, Pu Wang, Jianwen Xu
Summary: This study found that intermittent theta burst stimulation with bilateral cerebellar transcranial magnetic stimulation can effectively improve swallowing function in patients with dysphagia after stroke. The stimulation of bilateral cerebellar hemisphere provides a more efficient treatment. Additionally, 100% resting motor threshold bilateral cerebellar iTBS is a relatively safe treatment.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Anna Sadnicka, Lorenzo Rocchi, Anna Latorre, Elena Antelmi, James Teo, Isabel Parees, Britt S. Hoffland, Kristian Brock, Katja Kornysheva, Mark J. Edwards, Kailash P. Bhatia, John C. Rothwell
Summary: This study aimed to examine the influence of dystonia on eyeblink conditioning and explore its relationship with sex, age, and dystonia subtypes. The results showed that isolated dystonia and its subtypes had similar eyeblink conditioning levels compared to the control group, and a wide range of variability was observed in both healthy individuals and dystonia patients. This finding suggests that there is no global cerebellar learning deficit in isolated dystonia.
MOVEMENT DISORDERS
(2022)
Article
Psychology, Clinical
Samantha N. Sallie, Saurabh Sonkusare, Alekhya Mandali, Violeta Casero, Hailun Cui, Natalie V. Guzman, Michael Allison, Valerie Voon
Summary: Response inhibition is impaired in neuropsychiatric disorders, including addiction. Cortical paired associative stimulation can enhance response inhibition performance in healthy individuals. However, this effect is not observed in chronic alcohol users.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Recep A. Ozdemir, Pierre Boucher, Peter J. Fried, Davide Momi, Ali Jannati, Alvaro Pascual-Leone, Emiliano Santarnecchi, Mouhsin M. Shafi
Summary: Recent research has shown significant variability in responses to TBS protocols, challenging the assumed reliability and lasting effects on cortical excitability. While TMS combined with EEG revealed stable responses to single pulse TMS across visits, the modulatory effects of TBS varied substantially both between and within individuals. The generally accepted mechanisms of TBS-induced neuromodulation through cortical excitability changes may not be accurate, highlighting the need for further research to understand the therapeutic effects of TBS in neuropsychiatry and examine the reproducibility of TBS-induced neuromodulation.
Review
Psychology, Developmental
Veit Roessner, Heike Eichele, Jeremy S. Stern, Liselotte Skov, Renata Rizzo, Nanette Mol Debes, Peter Nagy, Andrea E. Cavanna, Cristiano Termine, Christos Ganos, Alexander Muenchau, Natalia Szejko, Danielle Cath, Kirsten R. Mueller-Vahl, Cara Verdellen, Andreas Hartmann, Aribert Rothenberger, Pieter J. Hoekstra, Kerstin J. Plessen
Summary: The first European guidelines for Tourette Syndrome (TS) were published in 2011 by the European Society for the Study of Tourette Syndrome (ESSTS). The updated part on pharmacological treatment emphasizes the importance of psychoeducation and behavioral approaches as first-line treatments. Pharmacological treatment, particularly with dopamine blocking agents like aripiprazole, is indicated in some patients, especially when behavioral approaches are not effective or feasible. Treatment should be individualized based on the patient's needs, preferences, and co-existing conditions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Engineering, Biomedical
Jose Gomez-Feria, Mariano Fernandez-Corazza, Juan F. Martin-Rodriguez, Pablo Mir
Summary: This study aims to determine the optimal coil orientations for transcranial magnetic stimulation (TMS) in three clinically relevant brain areas: pre-SMA, IFG, and PPC. The results show that the spatial focality of the electric field (E-field) generated by TMS varies depending on the coil orientation, and is influenced by individual brain anatomical properties. Better coil orientations can be based on the specific brain morphology at the region of interest (VOI).
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Cristiano Termine, Linda Greta Dui, Laura Borzaga, Vera Galli, Rossella Lipari, Marta Vergani, Valentina Berlusconi, Massimo Agosti, Francesca Lunardini, Simona Ferrante
Summary: A cross-sectional study compared the effects of social distancing and lifestyle changes during the COVID-19 lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). Results showed that NDDs significantly impacted remote learning, sociality, scolding, and anxiety levels. There was agreement between parents and children regarding remote learning, lifestyle, and scolding. This study highlights the importance of supportive strategies for youth with NDDs during periods of lockdown.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Cristiano Termine, Vera Galli, Linda Greta Dui, Valentina Berlusconi, Rachele Taras, Marta Vergani, Francesca Lunardini, Simona Ferrante, Andrea Eugenio Cavanna
Summary: This study investigated the impact of the COVID-19 lockdown on children and adolescents with tic disorders in Italy. The findings showed that about 50% of the patients reported changes in tic severity, restlessness, and irritability during the lockdown. Difficulties with remote learning increased, but feelings of missing out on social interactions decreased.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Maria Teresa Perinan, Kajsa Brolin, Sara Bandres-Ciga, Cornelis Blauwendraat, Christine Klein, Ziv Gan-Or, Andrew Singleton, Pilar Gomez-Garre, Maria Swanberg, Pablo Mir, Alastair Noyce
Summary: Parkinson's disease is a complex neurodegenerative condition caused by interactions between genetic and environmental factors. This article provides insights into the environmental modifiers of Parkinson's disease, discusses precedents from other neurological conditions, outlines genetic and environmental factors contributing to the disease, and reviews potential environmental modifiers affecting its severity.
ANNALS OF NEUROLOGY
(2022)
Review
Education, Special
Chiara Luoni, Maristella Scorza, Silvia Stefanelli, Barbara Fagiolini, Cristiano Termine
Summary: Developmental dyscalculia (DD) is closely related to other learning and developmental disabilities, such as reading and writing disorders, attention deficits, and problems in visual/spatial skills and memory. This study found that children with DD have different cognitive and neuropsychological profiles compared to typically developing children.
JOURNAL OF LEARNING DISABILITIES
(2023)
Letter
Clinical Neurology
Giacomo Koch, Alessandro Martorana
Article
Chemistry, Analytical
Chiara Piazzalunga, Linda Greta Dui, Cristiano Termine, Marisa Bortolozzo, Matteo Matteucci, Simona Ferrante
Summary: Dysgraphia is a learning disability characterized by below-average handwriting production. This study examines the role of visual perception in handwriting skills through gamified visual perception tests played with an eye tracker. Machine learning models using game performance, eye-tracking, and drawing data as predictors successfully predicted children at risk of dysgraphia. These results suggest the potential of a new tool for early screening of dysgraphia based on visual perception skills.
Article
Clinical Neurology
Esther Cubo, Sheng Luo, Pablo Martinez-Martin, Glenn T. Stebbins, Jeffrey Lin, Dongrak Choi, Alvaro Garcia-Bustillo, Pablo Mir, Diego Santos-Garcia, Marcos Serrano-Duenas, Mayela Rodriguez-Violante, Carlos Singer
Summary: This article summarizes the formal process of completing the MDS-NMS program and presents data on the first non-English version (Spanish). The results show that the Spanish version of MDS-NMS met the criteria to be designated as an official translation and is now available on the MDS website.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Konstantin G. Heimrich, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino Prell
Summary: Nonmotor symptoms have a negative impact on health-related quality of life in patients with Parkinson's disease. This study aimed to understand the network structure of nonmotor symptoms and their impact on quality of life, particularly focusing on the most influential symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Konstantin Heimrich, Sarah Mendorf, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino COPPADIS Study Group, Tino Prell
Summary: The clinical presentation of Parkinson's disease is often characterized by depressive symptoms, which significantly affect the patients' quality of life. Through network analysis, this study identified the depressive symptoms of loss of energy, past failure, and tiredness or fatigue as having the greatest impact on overall quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Proceedings Paper
Computer Science, Information Systems
Linda Greta Dui, Simone Toffoli, Christopher Speziale, Cristiano Termine, Matteo Matteucci, Simona Ferrante
Summary: This article proposes a method to address handwriting difficulties in children by analyzing drawings produced in the preliteracy stage to predict future handwriting problems. This is an important step towards early intervention for handwriting issues.
2022 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) JOINTLY ORGANISED WITH THE IEEE-EMBS INTERNATIONAL CONFERENCE ON WEARABLE AND IMPLANTABLE BODY SENSOR NETWORKS (BSN'22)
(2022)
