Article
Health Care Sciences & Services
Rajan Kashyap, Sagarika Bhattacharjee, Ramaswamy Arumugam, Rose Dawn Bharath, Kaviraja Udupa, Kenichi Oishi, John E. Desmond, S. H. Annabel Chen, Cuntai Guan
Summary: The study introduced a dose-target determination index (DTDI) to quantify the focality of tDCS and found that individuals of different ages and genders show varying changes in focality when the current dose is increased. The nonlinear relationship between the injected tDCS current and the distribution of current density in the target ROI is predominant in older adults, with males exhibiting a stronger decline in focality. Higher current doses in older age can enhance the focality of stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Clinical Neurology
B. Gonzalez-Rodriguez, N. Serradell-Ribe, R. Viejo-Sobera, J. P. Romero-Munoz, Elena M. Marron
Summary: This systematic review evaluated the effectiveness of transcranial direct current stimulation (tDCS) in the rehabilitation of hemispatial neglect after stroke. The findings indicate that tDCS can effectively improve neglect recovery, particularly when combined with other interventions. However, due to the limited number of studies and certain design risks, categorical conclusions cannot be drawn at this time. Further research is needed to determine the advantages of tDCS in stroke patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Forouzan Farahani, Greg Kronberg, Mohamad FallahRad, Hysell V. Oviedo, Lucas C. Parra
Summary: This study found that transcranial direct current stimulation (DCS) enhances synaptic plasticity by increasing postsynaptic somatic spiking, but also discovered that an increase in network activity may both boost and limit this enhancement.
Article
Anesthesiology
Sylvia Mechsner, Jackie Gruenert, Jakob Johann Wiese, Jane Vormbaeumen, Jalid Sehouli, Britta Siegmund, Lars Neeb, Magdalena Sarah Pruess
Summary: This study aimed to investigate the pain reduction effect of transcranial direct current stimulation (tDCS) in patients with endometriosis and chronic pelvic pain (CPP). The results showed significant decreased pain perception in both pain measurements for the active tDCS group compared with the placebo group.
Article
Clinical Neurology
Swarna Buddha Nayok, Harsh Pathak, Satish Suhas, Vani H. Thimmashetty, Prakrithi Shivaprakash, Ragibommanahalli M. Madhu Sudhan, Vanteemar S. Sreeraj, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian
Summary: This study reported the use of a novel tDCS protocol in a patient with both schizophrenia and OCD, demonstrating clinical utility by reducing symptoms of both disorders.
Review
Neurosciences
Peiwei Hong, Yao Liu, Yang Wan, Hai Xiong, Yanming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the efficacy and safety of transcranial direct current stimulation (tDCS) for migraine treatment. The results showed that tDCS activated or inhibited specific brain areas could reduce the number of migraine days per month in patients with migraine. tDCS was found to be an effective, preventive, and safe treatment option for migraine.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Psychology, Multidisciplinary
Luiza Grycuk, Francesca Moruzzi, Elena Bardjesteh, Fiona Gaughran, Iain C. Campbell, Ulrike Schmidt
Summary: The study provides insights into the perceptions and experiences of individuals with schizophrenia regarding transcranial direct current stimulation (tDCS). Participants were concerned about the safety of tDCS, but educational materials and a good relationship with the researcher helped alleviate their fears. Although participants found tDCS uncomfortable, they agreed that the unpleasant sensations were short-lived and did not cause long-term anxiety.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Clinical Neurology
Paloma Cristina Alves de Oliveira, Thiago Anderson Brito de Araujo, Daniel Gomes da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya
Summary: There was no significant short-term effect of tDCS alone on motor function, balance, gait, dyskinesias, or motor fluctuations in Parkinson's disease, regardless of brain area or the number of stimulated targets.
FRONTIERS IN NEUROLOGY
(2022)
Review
Engineering, Biomedical
Natalia Comino-Suarez, Juan C. Moreno, Julio Gomez-Soriano, Alvaro Megia-Garcia, Diego Serrano-Munoz, Julian Taylor, Monica Alcobendas-Maestro, Angel Gil-Agudo, Antonio J. del-Ama, Juan Avendano-Coy
Summary: The systematic review found that the combination of tDCS with RT did not improve upper limb function, strength, spasticity, functional independence, or velocity of movement after stroke. However, tDCS may enhance the effects of RT alone for lower limb function.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Neurosciences
Bas Labree, Derek J. Hoare, Lauren E. Gascoyne, Polly Scutt, Cinzia Del Giovane, Magdalena Sereda
Summary: This systematic review explores the potential of transcranial direct current stimulation (tDCS) in treating tinnitus and related depression symptoms, finding that tDCS has the potential to reduce symptoms of tinnitus and depression, and can identify potentially optimal stimulation parameters.
Review
Clinical Neurology
Reza Moshfeghinia, Dorsa Shekouh, Sara Mostafavi, Mehrnaz Hosseinzadeh, Amir Reza Bahadori, Saeed Abdollahifard, Ali Razmkon
Summary: This study systematically reviewed the effect of tDCS on pain reduction in FM patients. The results suggest that applying 2mA of tDCS to the left M1 area is the most effective strategy.
Article
Medicine, General & Internal
Perianen Ramasawmy, Sarah Khalid, Frank Petzke, Andrea Antal
Summary: This study investigated the preliminary clinical efficacy and feasibility of combining mindfulness meditation and transcranial direct current stimulation for pain management in fibromyalgia syndrome patients. While the bimodal therapy did not reduce pain intensity, the active group reported significantly higher quality of life post-treatment.
FRONTIERS IN MEDICINE
(2022)
Review
Nutrition & Dietetics
James Chmiel, Anna Gladka, Jerzy Leszek
Summary: Transcranial direct current stimulation (tDCS), a non-invasive brain neuromodulation technique, has shown potential in treating anorexia nervosa (AN). Studies have demonstrated that tDCS stimulation of the left dorsolateral prefrontal cortex (DLPFC) can improve AN clinical symptoms, alter eating behavior, body weight, food intake, and reduce depression symptoms.
Article
Behavioral Sciences
Mingliang Tan, Zhou Feng, Hui Chen, Lingxia Min, Huizhong Wen, Hongliang Liu, Jingming Hou
Summary: The study aims to investigate the effect of transcranial direct current stimulation (tDCS) on neuropathic pain induced by spinal cord injury (SCI) and its underlying mechanism. The results showed that tDCS significantly improved the thermal withdrawal threshold and motor function of SCI rats. In addition, tDCS regulated the concentrations of inflammatory and anti-inflammatory cytokines, promoted the phenotypic transformation of microglia, and effectively relieved SCI-induced neuropathic pain.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychiatry
Yuji Yamada, Zui Narita, Takuma Inagawa, Yuma Yokoi, Naotsugu Hirabayashi, Aya Shirama, Kazuki Sueyoshi, Tomiki Sumiyoshi
Summary: This study compared the effects of anodal stimulation targeting the left dorsolateral prefrontal cortex (DLPFC) and left superior temporal sulcus (STS) in patients with schizophrenia on daily-living skills, neurocognition, and psychotic symptoms. The results showed that anodal stimulation of the left DLPFC improved higher level functional outcomes and neurocognition, while stimulation of the STS had a smaller effect.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Shan H. Siddiqi, Stephan F. Taylor, Danielle Cooke, Alvaro Pascual-Leone, Mark S. George, Michael D. Fox
AMERICAN JOURNAL OF PSYCHIATRY
(2020)
Letter
Clinical Neurology
Joshua C. Brown, William H. DeVries, Jeffrey E. Korte, Gregory L. Sahlem, Leonardo Bonilha, E. Baron Short, Mark S. George
Article
Clinical Neurology
Gregory L. Sahlem, William McCall, E. Baron Short, Peter B. Rosenquist, James B. Fox, Nagy A. Youssef, Andrew J. Manett, Suzanne E. Kerns, Morgan M. Dancy, Laryssa McCloud, Mark S. George, Harold A. Sackeim
Letter
Clinical Neurology
Mark S. George, Kevin A. Caulfield, Kathleen O'Leary, Bashar W. Badran, E. Baron Short, Sarah M. Huffman, Xingbao Li, Suzanne E. Kerns, Nolan R. Williams
Review
Clinical Neurology
Simone Rossi, Andrea Antal, Sven Bestmann, Marom Bikson, Carmen Brewer, Jurgen Brockmoller, Linda L. Carpenter, Massimo Cincotta, Robert Chen, Jeff D. Daskalakis, Vincenzo Di Lazzaro, Michael D. Fox, Mark S. George, Donald Gilbert, Vasilios K. Kimiskidis, Giacomo Koch, Risto J. Ilmoniemi, Jean Pascal Lefaucheur, Letizia Leocani, Sarah H. Lisanby, Carlo Miniussi, Frank Padberg, Alvaro Pascual-Leone, Walter Paulus, Angel Peterchev, Angelo Quartarone, Alexander Rotenberg, John Rothwell, Paolo M. Rossini, Emiliano Santarnecchi, Mouhsin M. Shafi, Hartwig R. Siebner, Yoshikatzu Ugawa, Eric M. Wassermann, Abraham Zangen, Ulf Ziemann, Mark Hallett
Summary: This article is based on a consensus conference held in Siena, Italy in October 2018, aiming to update safety guidelines for the application of transcranial magnetic stimulation (TMS). New emerging issues discussed include safety concerns with recently developed stimulation devices, novel scenarios of TMS applications, and ethical considerations regarding neuroenhancement.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bashar W. Badran, Kevin A. Caulfield, Claire Cox, James W. Lopez, Jeffrey J. Borckardt, William H. DeVries, Philipp Summers, Suzanne Kerns, Colleen A. Hanlon, Lisa M. McTeague, Mark S. George, Donna R. Roberts
Article
Psychiatry
Leanne M. Williams, John T. Coman, Patrick C. Stetz, Nicole C. Walker, F. Andrew Kozel, Mark S. George, Jong Yoon, Laura M. Hack, Michelle R. Madore, Kelvin O. Lim, Noah S. Philip, Paul E. Holtzheimer
Summary: This study aims to evaluate the relationship between neural targets, cognitive-behavioral performance, and symptom severity, suicidality, and quality of life outcomes in pharmacoresistant depression patients undergoing TMS treatment. The results will help providers select suitable candidates for TMS treatment and predict treatment response more accurately.
Review
Clinical Neurology
Peter J. Fried, Emiliano Santarnecchi, Andrea Antal, David Bartres-Faz, Sven Bestmann, Linda L. Carpenter, Pablo Celnik, Dylan Edwards, Faranak Farzan, Shirley Fecteau, Mark S. George, Bin He, Yun-Hee Kim, Letizia Leocani, Sarah H. Lisanby, Colleen Loo, Bruce Luber, Michael A. Nitsche, Walter Paulus, Simone Rossi, Paolo M. Rossini, John Rothwell, Alexander T. Sack, Gregor Thut, Yoshikazu Ugawa, Ulf Ziemann, Mark Hallett, Alvaro Pascual-Leone
Summary: This article provides recommendations for training practitioners in the safe and effective administration of NIBS techniques, covering three different types of practitioners. It discusses the basic and advanced knowledge and skills that practitioners need to possess, as well as recommendations for curriculum components. The article also encourages licensing and governing bodies to implement these guidelines.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Kevin A. Caulfield, Aprinda Indahlastari, Nicole R. Nissim, James W. Lopez, Holly H. Fleischmann, Adam J. Woods, Mark S. George
Summary: Using reverse-calculation modeling to individualize tDCS doses can reduce electric field variance at the cortex, potentially leading to more effective treatments for working memory.
Article
Multidisciplinary Sciences
Alicia K. Smith, Andrew Ratanatharathorn, Adam X. Maihofer, Robert K. Naviaux, Allison E. Aiello, Ananda B. Amstadter, Allison E. Ashley-Koch, Dewleen G. Baker, Jean C. Beckham, Marco P. Boks, Evelyn Bromet, Michelle Dennis, Sandro Galea, Melanie E. Garrett, Elbert Geuze, Guia Guffanti, Michael A. Hauser, Seyma Katrinli, Varun Kilaru, Ronald C. Kessler, Nathan A. Kimbrel, Karestan C. Koenen, Pei-Fen Kuan, Kefeng Li, Mark W. Logue, Adriana Lori, Benjamin J. Luft, Mark W. Miller, Jane C. Naviaux, Nicole R. Nugent, Xuejun Qin, Kerry J. Ressler, Victoria B. Risbrough, Bart P. F. Rutten, Murray B. Stein, Robert J. Ursano, Eric Vermetten, Christiaan H. Vinkers, Lin Wang, Nagy A. Youssef, Monica Uddin, Caroline M. Nievergelt
NATURE COMMUNICATIONS
(2020)
Letter
Clinical Neurology
Samantha L. Cohen, Marom Bikson, Bashar W. Badran, Mark S. George
Article
Clinical Neurology
Ryan D. Webler, James Fox, Lisa M. McTeague, Philip C. Burton, Logan Dowdle, Edward Baron Short, Jeffrey J. Borckardt, Xingbao Li, Mark S. George, Ziad Nahas
Summary: In this study, the researchers used interleaved TMS-fMRI to manipulate and observe neural activity during high cognitive load conditions. They found that TMS delivered during high cognitive load strengthened cognitive processing and increased activation in FPN nodes and deactivation in DMN nodes. These results suggest that exogenous perturbation of the DLPFC via single pulse TMS can enhance high cognitive demand processing.
Review
Medicine, General & Internal
Claudia A. A. Salazar, Wuwei Feng, Leonardo Bonilha, Steven Kautz, Jens H. H. Jensen, Mark S. S. George, Nathan C. Rowland
Summary: During rehabilitation, transcranial direct current stimulation (tDCS) can be used to prime the motor system of stroke patients and potentially enhance therapy outcomes. However, the efficacy of tDCS varies among patients, which may be influenced by factors such as cortical infarct regions, motor tract injury, and connectivity changes. Neuroimaging techniques are needed to quantify these factors and understand the impact on tDCS delivery. This review summarizes the development of tDCS for stroke from a neuroimaging perspective and discusses potential strategies for personalized tDCS based on anatomy, connectivity, and brain activation dynamics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Clinical Neurology
Melanie W. Gail, Catrina Sims-Robinson, Heather Boger, Adviye Ergul, Rupak Mukherjee, Dorothea D. Jenkins, Mark S. George
Review
Neurosciences
Giuseppina Pilloni, Marom Bikson, Bashar W. Badran, Mark S. George, Steven A. Kautz, Alexandre Hideki Okano, Abrahao Fontes Baptista, Leigh E. Charvet
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
