Article
Biochemistry & Molecular Biology
Peter Santha, Szandra Lakatos, Agnes Horvath, Maria Dux, Gabor Jancso
Summary: The study found that perineural capsaicin treatment can produce long-lasting thermo- and chemo-analgesia and eliminate neurogenic inflammatory response. The experiment on rats showed that capsaicin treatment significantly reduced mustard oil-induced vasodilatation and the effect lasted for at least 7 weeks. After transection and ligation of the capsaicin-treated nerve, a substantial recovery of vasodilatatory response was observed, indicating collateral sprouting of intact nerve fibers into the chemodenervated skin area. These findings have implications for understanding the development of sensory disturbances following peripheral nerve injuries.
Article
Biochemistry & Molecular Biology
Nobuhiko Nakajima, Yuichiro Ohnishi, Masamichi Yamamoto, Daiki Setoyama, Hirohiko Imai, Tomofumi Takenaka, Mari Matsumoto, Koichi Hosomi, Yoichi Saitoh, Hidemasa Furue, Haruhiko Kishima
Summary: Intractable neuropathic pain following spinal cord injury (NP-SCI) reduces a patient's quality of life. Excessive buildup of intracellular ATP at the lesion site leads to the release of ATP with mechanical stimulation, causing NP-SCI. Neuroinflammation plays an important role in this process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang
Summary: The study found that purinergic receptor P2RX1 is highly expressed in acute pancreatitis and plays a role in promoting neutrophil activation to contribute to the inflammatory response, making it a potential therapeutic target for treating the disorder inflammation in acute pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Ying-Yi Lu, Hung-Pei Tsai, Tai-Hsin Tsai, Hsiao-Chien Miao, Zi-Hao Zhang, Chieh-Hsin Wu
Summary: Neuropathic pain following nerve injury is a complex condition that has a negative impact on life. This study found that RTA-408 has a therapeutic effect on mechanical allodynia in chronic constriction injury rats. RTA-408 reduces neuronal apoptosis and glial cell activation by regulating NF-κB and Nrf-2 expression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Xu Wang, Xiao Yuan, Yuting Su, Jing Hu, Qian Ji, Shengqiao Fu, Rongkun Li, Lipeng Hu, Chunhua Dai
Summary: Inflammatory bowel disease (IBD) is a common gastrointestinal disease worldwide. Purinergic signaling is a potential therapeutic target for IBD, with purinergic receptor P2RX1 playing a significant role in regulating inflammation in colon tissues. Genetic knockout of P2RX1 reduces inflammation and neutrophil infiltration, alters gut microbiota, upregulates the indole alkaloid biogenesis pathway, and activates the aryl hydrocarbon receptor (AhR)/IL-22 axis to provide therapeutic benefits. Targeting P2RX1 may offer a novel therapeutic strategy for IBD, with P2RX1 inhibitor enhancing the efficacy of anti-TNF-alpha therapy in mouse colitis models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Sreenath P. Kyathanahally, Michela Azzarito, Jan Rosner, Vince D. Calhoun, Claudia Blaiotta, John Ashburner, Nikolaus Weiskopf, Katja Wiech, Karl Friston, Gabriel Ziegler, Patrick Freund
Summary: This study tracked the structural changes in nociceptive pathways after spinal cord injury and their relationship to neuropathic pain intensity. Results showed differences in structural parameters in specific brain and spinal cord regions of individuals with neuropathic pain, indicating a critical role of microstructural changes in neuropathic pain maintenance.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Review
Neurosciences
Bo Yang, Nengwei Yu
Summary: Past studies have shown that Chinese herbal medicine can alleviate neuropathic pain by targeting purinergic receptor P2. This review discusses the mechanism of traditional Chinese medicine in targeting P2 receptors to relieve neuropathic pain, providing references for future drug development.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Kai Sun, Hao Zhang, Ting Zhang, Nan Sun, Jingru Hao, Zhiping Wang, Can Gao
Summary: Neuropathic pain is often accompanied by psychiatric comorbidities and lacks effective treatment. This study reveals that HDAC6 plays a crucial role in the development and maintenance of neuropathic pain through neuronal activation and neuroinflammatory responses. HDAC6 may be a promising target for treating neuropathic pain.
Article
Neurosciences
Robert S. Talay, Yaling Liu, Matthew Michael, Anna Li, Isabel D. Friesner, Fei Zeng, Guanghao Sun, Zhe Sage Chen, Qiaosheng Zhang, Jing Wang
Summary: The study found that AMPAkines can restore endogenous anti-nociceptive functions in the PL-PFC region, providing a successful strategy for treating chronic neuropathic pain.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Immunology
Jaesung Lee, Giljae Lee, Gwangpyo Ko, Sung Joong Lee
Summary: This study highlights the impact of the gut microbiota on glial cell growth and maturation through the gut-brain axis. Depletion of the gut microbiota using antibiotics prevented nerve injury-induced pain in mice, and recolonization of the gut microbiota resulted in the relapse of pain. The diversity and composition of the gut microbiome were altered by nerve injury, and probiotic treatment before nerve injury alleviated pain sensitization.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Jesse K. Niehaus, Bonnie Taylor-Blake, Lipin Loo, Jeremy M. Simon, Mark J. Zylka
Summary: Peripheral nerve injury leads to long-term pro-inflammatory responses in spinal cord glial cells, but the identity of endogenous cells that resolve spinal inflammation has not been determined. Our study demonstrates that MRC1(+) spinal cord macrophages actively restrain glia to limit neuroinflammation and resolve mechanical pain following superficial injury, suggesting that therapeutic modulation of spinal macrophages could promote long-lasting recovery of neuropathic pain.
Review
Immunology
Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mansour Haddad, Federica Cherchi, Mohammad Alsalem, Yousef M. Al-saraireh, Saba Madae'en
Summary: This review presents new findings on the role of adenosine and its receptors in neuropathic and inflammatory pain. Adenosine receptor ligands have shown promising efficacy and safety in clinical research and could be used as therapeutic targets for various pain disorders. The review also discusses the latest studies on adenosine receptor ligands in different pain models and the potential of newly synthesized allosteric adenosine receptor modulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Allison R. Reid, Patrice D. Cote, Jason J. McDougall
Summary: This study examines the effect of Na(v)1.7 channel blockade on joint pain and finds that it can alleviate joint pain associated with neural demyelination to some extent. Biologics that inactivate Na(v)1.7 channels have the potential to reduce arthritis pain over a protracted period of time.
Article
Neurosciences
Derek C. Molliver, Kristofer K. Rau, Michael P. Jankowski, Deepak J. Soneji, Kyle M. Baumbauer, H. Richard Koerber
Article
Neurosciences
Xiaowei Chen, Derek C. Molliver, G. F. Gebhart
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Sacha Malin, Derek Molliver, Julie A. Christianson, Erica S. Schwartz, Pam Cornuet, Kathryn M. Albers, Brian M. Davis
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Ting Wang, Xiaotang Jing, Jennifer J. DeBerry, Erica S. Schwartz, Derek C. Molliver, Kathryn M. Albers, Brian M. Davis
JOURNAL OF NEUROSCIENCE
(2013)
Review
Biochemistry & Molecular Biology
Laura S. Stone, Derek C. Molliver
MOLECULAR INTERVENTIONS
(2009)
Article
Neurosciences
Sacha A. Malin, Derek C. Molliver
Article
Neurosciences
Derek C. Molliver, Kristofer K. Rau, Sabrina L. McIlwrath, Michael P. Jankowski, H. Richard Koerber
Article
Neurosciences
H. O. Vongtau, E. G. Lavoie, J. Sevigny, D. C. Molliver
Article
Anesthesiology
Sacha A. Malin, Brian M. Davis, H. Richard Koerber, Ian J. Reynolds, Kathryrn M. Albers, Derek C. Molliver
Article
Anesthesiology
Michael P. Jankowski, Kristofer K. Rau, Deepak J. Soneji, Katrina M. Ekmann, Collene E. Anderson, Derek C. Molliver, Richard Koerber
Article
Multidisciplinary Sciences
Ting Wang, Derek C. Molliver, Xiaotang Jing, Erica S. Schwartz, Fu-Chia Yang, Omar Abdel Samad, Qiufu Ma, Brian M. Davis
Article
Cell Biology
Diana J. Goode, Derek C. Molliver
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Virology
Courtney A. Rieder, Jonathan Rieder, Sebastian Sannajust, Diana Goode, Ramaz Geguchadze, Ryan E. Relich, Derek C. Molliver, Tamara E. King, James Vaughn, Meghan May
Article
Biochemical Research Methods
Sacha A. Malin, Brian M. Davis, Derek C. Molliver