期刊
BRAIN RESEARCH BULLETIN
卷 103, 期 -, 页码 29-38出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2013.12.006
关键词
Schizophrenia; Alzheimer's disease; Mental disorder; Genetic; Glutamatergic; Postmortem
资金
- NIH-NIMH [R01MH071316]
- Veterans Health Administration [BX000452]
- NIH [MH071533, AG005133]
- National Center for Research Resources (NCRR)
- National Center for Advancing Translational Sciences (NCATS)
- National Institutes of Health (NIH) [8UL1TR000150]
Changes in dendritic spines structure and function play a critical role in a number of physiological processes, including synaptic transmission and plasticity, and are intimately linked to cognitive function. Alterations in dendritic spine morphogenesis occur in a number of neuropsychiatric disorders and likely underlie the cognitive and behavioral changes associated with these disorders. The neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. Moreover, a series of recent studies have genetically and functionally linked kalirin signaling to several disorders, including schizophrenia and Alzheimer's disease. Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target. This article is part of a special Issue entitled 'Dendrites and Disease'. (C) 2013 Elsevier Inc. All rights reserved.
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