Article
Biochemistry & Molecular Biology
Xiaolu Lei, Junwei Zeng, Yan Yan, Xiaohong Liu
Summary: This study aimed to investigate the modulation of HCN channel activity on the expression and function of P2X2 and P2X3 receptors. The results showed that intrathecal administration of HCN channel blocker ZD7288 significantly reduced mechanical hyperalgesia and the increased expression of P2X2 and P2X3 receptors in rats with chronic constriction injury of sciatic nerve. Furthermore, it was found that the opening of HCN channels could enhance the expression and function of P2X2 and P2X3 receptors via the cAMP-PKA signaling pathway. These findings provide important insights into the mechanism of nerve injury-induced pain hypersensitivity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Article
Pharmacology & Pharmacy
Lin Yao, Tian-Yu Zhang, Xin-Tong Diao, Juan-Juan Ma, Hu-Hu Bai, Zhan-Wei Suo, Yan-Ni Liu, Xian Yang, Xiao-Dong Hu
Summary: The glycine receptor, consisting of α1 subunits, plays a crucial role in inhibitory neurotransmission and may serve as an effective target for pain therapy in the peripheral nervous system. Inflammation in the periphery can reduce the expression of glycine receptors on the plasma membrane of neurons. Glycine receptor agonists or positive modulators show promise in alleviating pain behaviors induced by inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Hilary R. Katz, Anthony A. Arcese, Ona Bloom, Jennifer R. Morgan
Summary: The regenerative capacity of vertebrate nervous system varies greatly among species and neuronal populations. Activating transcription factor 3 (ATF3) has been identified as a conserved pro-regenerative factor that promotes neuronal axon regrowth and regeneration in various species. It is induced in neurons shortly after injury and its expression is found to be critical for axon regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Biochemistry & Molecular Biology
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Summary: The sodium-activated potassium channel Slack plays a role in sensory neurons and is involved in mediating sodium-activated potassium current (I-KNa) and modulating neuronal activity. Studies found that Slack activity is reduced in sensory neurons after peripheral nerve injury, contributing to neuropathic pain hypersensitivity, and that it is associated with ATP-sensitive P2X3 receptors. Experiments showed that Slack-mediated I-KNa can be bidirectionally modulated in response to P2X3 activation, suggesting a potential novel strategy for treating neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yongmin Liu, Min Jia, Caihua Wu, Hong Zhang, Chao Chen, Wenqiang Ge, Kexing Wan, Yuye Lan, Shiya Liu, Yuanheng Li, Mengyue Fang, Jiexi He, Hui-Lin Pan, Jun-Qiang Si, Man Li
Summary: The study reveals that conditional knockout of CB1 in primary sensory neurons leads to persistent hyperalgesia and altered transcriptome expression in the DRG. CB2 expression is regulated by CB1 and may serve as a target for neuropathic pain treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Aseer Intisar, Seung Joon Lee, Yu-Gyeong Kim, Woon-Hae Kim, Hyun Young Shin, Min Young Kim, Jong Man Kim, Jungmin Lee, Yun Jeoung Mo, Yu Seon Kim, Seung-Hoon Kim, Yun-Il Lee, Minseok S. Kim
Summary: This study introduces a rapid method for enriching neurons from the mouse embryonic dorsal root ganglion using fully-automated continuous centrifugal microfluidics, achieving effective isolation within 13 minutes. The purified neurons showed improved viability and purity compared to conventional chemical purification methods, highlighting the potential of this automated system to advance neurological research.
Article
Cell Biology
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: The study reveals that Slack serves as a modulator of TRPA1-mediated activation of sensory neurons, but not TRPV1-mediated activation.
Article
Anesthesiology
Xiao-Long Zhang, Jin-Jun Zhang, Zi-Hang Chen, Kai-Bin Yang, Xi Zhang, Yi-Bin Xiao, Yi Lei, Xian-Ying Cao, Man-Xiu Xie
Summary: Research has shown that the SIRT1 protein plays a role in the different pain vulnerability of adults and minors. The interaction between SIRT1 and the ClC-3 channel contributes to the pain vulnerability difference between adults and minors. Additionally, there is a negative correlation between serum SIRT1 levels and pain scores in chronic pain patients.
Article
Neurosciences
Wen-Long Qiao, Qing-Rui Qin, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: P2X3 receptors and group II mGluRs are expressed in primary sensory neurons. Activation of group II mGluRs inhibits the electrophysiological activity of P2X3 receptors. LY354740, a group II mGluR agonist, decreases the inward currents mediated by P2X3 receptors in rat DRG neurons.
Article
Clinical Neurology
Ricardo H. Roda, David Bargiela, Weiran Chen, Ken Perry, Ronald J. Ellis, David B. Clifford, Ajay Bharti, Asha R. Kallianpur, Michelli F. Oliveira, Monica M. Diaz, Leah H. Rubin, Christina Gavegnano, Justin C. McArthur, Ahmet Hoke, Michael Polydefkis
Summary: The study aimed to evaluate the correlation of large mtDNA deletions in skin samples of people with HIV with measures of neuropathy and prior exposure to therapy. Results showed a correlation between the total mtDNA deletion and intraepidermal nerve fiber density (IENFD) and sural nerve amplitude in PWH with HIV-associated sensory neuropathy.
Article
Cell Biology
Anand Krishnan, Aparna Areti, Prashanth Komirishetty, Ambika Chandrasekhar, Chu Cheng, Douglas W. Zochodne
Summary: This study reveals previously unrecognized structural adaptations in adult sensory neurons as a response to growth restraint and associated stress. The neurons modify their cytoskeleton and undergo macrovesicle shedding and neuron size adjustment as survival mechanisms. Additionally, changes in mRNA associated with autophagy were observed in axotomized neurons. These findings provide insights into the resilience of adult sensory neurons to various insults.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Runan Yang, Lin Li, Huilong Yuan, Hui Liu, Yingxin Gong, Lifang Zou, Shunhua Li, Zilin Wang, Liran Shi, Tianyu Jia, Shanhong Zhao, Bing Wu, Zhihua Yi, Yun Gao, Guilin Li, Hong Xu, Shuangmei Liu, Chunping Zhang, Guodong Li, Shangdong Liang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Lifang Zou, Kehua Yu, Yang Fan, Suixia Cao, Shuangmei Liu, Liran Shi, Lin Li, Huilong Yuan, Runan Yang, Zhihua Yi, Yun Gao, Guilin Li, Wolfgang Greffrath, Rolf-Detlef Treede, Man Li, Hong Xu, Chunping Zhang, Shangdong Liang
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Neurosciences
Wei Xiong, Mengxia Tan, Zhoujie Tong, Cancan Yin, Lingkun He, Lijuan Liu, Yulin Shen, Shu Guan, Huixiang Ge, Guodong Li, Shangdong Liang, Yun Gao
BRAIN RESEARCH BULLETIN
(2019)
Review
Biochemistry & Molecular Biology
Yuanzhen Hao, Huixiang Ge, Mengyun Sun, Yun Gao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Huixiang Ge, Shu Guan, Yulin Shen, Mengyun Sun, Yuanzhen Hao, Lingkun He, Lijuan Liu, Cancan Yin, Ruoyu Huang, Wei Xiong, Yun Gao
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Lijuan Liu, Lingkun He, Cancan Yin, Ruoyu Huang, Wenhao Shen, Huixiang Ge, Mengyun Sun, Shujuan Li, Yun Gao, Wei Xiong
SCIENTIFIC REPORTS
(2020)
Correction
Neurosciences
Changshui Xu, Guilin Li, Yun Gao, Shuangmei Liu, Jiari Lin, Jun Zhang, Xin Li, Han Liu, Shangdong Liang
BRAIN RESEARCH BULLETIN
(2020)
Correction
Biochemistry & Molecular Biology
Lifang Zou, Guihua Tu, Wei Xie, Shiyao Wen, Qiuyu Xie, Shuangmei Liu, Guilin Li, Yun Gao, Hong Xu, Shouyu Wang, Yun Xue, Bing Wu, Qiulan Lv, Mofeng Ying, Xi Zhang, Shangdong Liang
PURINERGIC SIGNALLING
(2020)
Correction
Biochemistry & Molecular Biology
Xin Li, Jun Zhang, Yun Gao, Yang Yang, Changshui Xu, Guilin Li, Guanghua Guo, Shuangmei Liu, Jinyan Xie, Shangdong Liang
PURINERGIC SIGNALLING
(2020)
Article
Biochemistry & Molecular Biology
Lequan Wen, Lirui Tang, Mingming Zhang, Congrui Wang, Shujuan Li, Yuqing Wen, Hongcheng Tu, Haokun Tian, Jingyi Wei, Peiwen Liang, Changsen Yang, Guodong Li, Yun Gao
Summary: This study investigated whether gallic acid could alleviate comorbid visceral pain and depression by reducing the expression of the P2X7 receptor. The results demonstrated that gallic acid was able to relieve pain and depression, while also reducing the expressions of the P2X7 receptor and p-ERK1/2. Gallic acid treatment also decreased inflammatory cytokines IL-1 beta and TNF-alpha levels, while increasing IL-10 levels in the serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mingming Zhang, Yuqing Wen, Peiwen Liang, Changsen Yang, Hongcheng Tu, Jingyi Wei, Junpei Du, Ting Zhan, Shangdong Liang, Guodong Li, Yun Gao
Summary: Obesity can cause chronic inflammation and increase sympathetic nervous system activity, leading to neuropathic injury. Imperatorin has anti-inflammatory effects and can affect the expression of P2X4 receptors in sympathetic ganglia, providing protection against cardiac neuropathic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Zhihua Yi, Lihui Xie, Congfa Zhou, Huilong Yuan, Shuai Ouyang, Zhi Fang, Shanhong Zhao, Tianyu Jia, Lifang Zou, Shouyu Wang, Yun Xue, Bing Wu, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Changshui Xu, Chunping Zhang, Shangdong Liang
PURINERGIC SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Huixiang Ge, Mengyun Sun, Xingyu Wei, Mingming Zhang, Hongcheng Tu, Yuanzhen Hao, Ruxin Chen, Miao Ye, Yun Gao
PURINERGIC SIGNALLING
(2020)
Correction
Neurosciences
Jiari Lin, Guilin Li, Xiaorong Den, Changshui Xu, Shuangmei Liu, Yun Gao, Han Liu, Jun Zhang, Xin Li, Shangdong Liang
BRAIN RESEARCH BULLETIN
(2020)
