Article
Behavioral Sciences
Michael T. Sapko, Taleen Hanania, Qing Chang, Jonathan C. Javitt
Summary: This study aimed to evaluate the abuse liability of D-cycloserine (DCS) using a self-administration paradigm. The results showed that DCS did not result in self-administration at any of the test doses and had similar behavior to the control group.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Clinical Neurology
Jaeden Cole, Ben Selby, Zahinoor Ismail, Alexander McGirr
Summary: In a randomized double-blind placebo-controlled crossover study, it was found that motor plasticity in patients with Major Depressive Disorder (MDD) is rescued and stabilized by the NMDA-R partial agonist D-cycloserine. The results indicate that D-cycloserine can regulate changes in motor plasticity in MDD patients.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Shunsuke Takagi, Darrick T. Balu, Joseph T. Coyle
Summary: The study found that the NMDAR antagonist MK801 and cocaine, drugs that enhance glutamate release, reduce the expression of SR and DAAO, while D-serine and antipsychotics do not regulate their protein levels. This suggests a new mechanism by which AMPAR activity regulates NMDAR function through D-serine availability.
Article
Biochemistry & Molecular Biology
Huayue Liu, Xiaowen Meng, Yixuan Li, Shiwen Chen, Yumeng Ji, Shaoyong Song, Fuhai Ji, Xin Jin
Summary: This study investigated the effects of sevoflurane anesthesia in neonatal mice on social behavior. The results showed that mice undergoing sevoflurane anesthesia exhibited strong social capabilities and weak preference for social novelty in their juvenile age. In early adulthood, male mice recovered normal preference for social novelty, while female mice continued to show weak preference. The anesthesia also decreased the expression of PSD95 in the hippocampus of neonatal mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Chen
Summary: Sleep apnea disrupts physiological homeostasis and can lead to neuronal dysfunction and anxiety, without significant impact on cognitive function. Chronic intermittent hypoxia alters synaptic plasticity in the brain, resulting in anxiety-like behaviors in mice. Treatment with NMDA receptor antagonist attenuates anxiety-like behavior induced by chronic IH, suggesting early intervention is important in managing anxiety-related complications in sleep apnea patients.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sighild Lemarchant, Melissa Sourioux, Juliette Le Douce, Alexandre Henriques, Noelle Callizot, Sandrine Hugues, Melissa Farinelli, Yann Godfrin
Summary: NX210c enhances excitatory synaptic currents and synaptic transmission in the brain, leading to improved memory. By modulating synaptic transmission and signaling, NX210c presents an innovative therapeutic opportunity for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Steven M. LeVine, Sheila Tsau
Summary: Krabbe disease is a lysosomal storage disease caused by a deficiency in galactosylceramidase. Current treatment methods have limited effectiveness, but preclinical studies have shown progress, especially in gene therapy and substrate reduction therapy. D-cycloserine has shown potential as a therapy in animal experiments, extending the lifespan of twitcher mice.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Plant Sciences
Bo-Ram Lee, Ju-Hyun Lee, Yong-Hyun Ko, Jee-Yeon Seo, Kwang-Hyun Hur, Young-Jung Kim, Seon-Kyung Kim, Seong-Eon Kim, Seok-Yong Lee, Choon-Gon Jang
Summary: Korean Red Ginseng (KRG) treatment alleviated anxiety-like behaviors and reduced social avoidance behavior induced by chronic social defeat stress (CSDS) in mice. It also recovered N-methyl-D-aspartate receptor protein levels in the hippocampus, indicating a therapeutic effect on CSDS-induced mood disorders.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qingcai Chen, Wei Chu, Rui Sheng, Shaoyong Song, Jianping Yang, Fuhai Ji, Xin Jin
Summary: The study found that maternal anesthesia with sevoflurane could induce social interaction deficits in offspring mice, particularly impacting the preference for social novelty in a long-lasting manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ying Chen, Wenqing Xu, Yuan Yuan, Houyang Chen, Shuangyan Zheng, Yuanqiao He, Tao Luo
Summary: The study found that the N-methyl-D-aspartic acid receptor may be involved in the inhibitory effect of ketamine on human sperm function, while NMDA can reverse the inhibitory effect of ketamine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Edel M. Hughes, Patricia Calcagno, Connie Sanchez, Karen Smith, John P. Kelly, David P. Finn, Michelle Roche
Summary: This study found differential effects of acute morphine administration on social behavior and immediate early gene expression in rats prenatally exposed to VPA compared to saline-exposed controls. Morphine had a smaller impact on sociability and social novelty preference behavior in VPA-exposed rats but affected immediate early gene expression in the hippocampus.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Wu Yong, Dongming He, Taiheng Chen, Zeng Rui, Yinchuan Wen, Kin Fung Wong, Lei Sun, Xiaofei Qi, Jinghui Guo
Summary: Ultrasound stimulation is a safe and precise method for investigating brain function and treating brain diseases. This study explores the role of NMDA receptors in mediating the effects of ultrasound on hippocampal neurons. The findings demonstrate that ultrasound activates NMDA receptor subunits in cells and primary neurons, leading to calcium influx and increased c-Fos expression. These findings enhance our understanding of the molecular mechanisms of ultrasound neuromodulation and its potential for sonogenetics.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Giulia Murtas, Loredano Pollegioni
Summary: D-amino acids have been found to play important roles in specific cancer types, including cancer cell proliferation, cell protection during therapy, and as potential biomarkers. More research is needed on the relationship between D-amino acids, their nutritional value, and cancer cell proliferation and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Deborah K. Park, Samuel Petshow, Margarita Anisimova, Eden V. Barragan, John A. Gray, Ivar S. Stein, Karen Zito
Summary: This study shows that decreased D-serine levels associated with schizophrenia enhance ion flux-independent NMDAR signaling, leading to destabilized dendritic spines. This hypothesis was tested using the serine racemase knockout mouse model and the results support the hypothesis.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Jessica A. Burket, Andrew D. Benson, Amy H. Tang, Stephen I. Deutsch
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2015)
Article
Clinical Neurology
Jessica A. Burket, Andrew D. Benson, Torrian L. Green, Jerri M. Rook, Craig W. Lindsley, P. Jeffrey Conn, Stephen I. Deutsch
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2015)
Article
Neurosciences
Jessica A. Burket, Chelsea M. Young, Torrian L. Green, Andrew D. Benson, Stephen I. Deutsch
BRAIN RESEARCH BULLETIN
(2016)
Article
Neurosciences
Torrian L. Green, Jessica A. Burket, Stephen I. Deutsch
BRAIN RESEARCH BULLETIN
(2016)
Article
Clinical Neurology
Stephen I. Deutsch, Jessica A. Burket, Andrew D. Benson, Maria R. Urbano
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2016)
Article
Multidisciplinary Sciences
Frency Varghese, Jessica A. Burket, Andrew D. Benson, Stephen I. Deutsch, Christian W. Zemlin
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Review
Clinical Neurology
Jessica A. Burket, Stephen I. Deutsch
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Editorial Material
Clinical Neurology
Stephen I. Deutsch, Jessica A. Burket, Maria R. Urbano
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Jessica A. Burket, Jerrah C. Pickle, Allison M. Rusk, Bronson A. Haynes, Julia A. Sharp, Stephen Deutsch
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2020)
Review
Clinical Neurology
Stephen Deutsch, Jessica A. Burket
Summary: There is a growing expert consensus on prescribing and monitoring psychotropic medications for adults and older adults with intellectual disability (ID). However, there is limited empirical evidence to guide physicians in selecting specific categories of psychotropic medications for challenging behaviors. Challenges in applying diagnostic criteria and assigning psychiatric diagnoses to adults with ID lead to confusion surrounding medication selection. Long-term antipsychotic medication use is common for challenging behaviors, despite questionable efficacy, with some recommending short-term use for imminent dangerousness or threat to residential placements. Interdisciplinary treatment teams are essential for non-pharmacological plans and regular medication monitoring. Well-designed clinical trials are necessary for homogeneous samples, with a focus on safety and clinical outcomes. Innovative pharmacological strategies have been suggested to prevent adaptive function decline and improve cognition in adults with ID. Translational clinical trials addressing pathogenic mechanisms and challenging behaviors raise societal issues regarding protection of vulnerable populations and prioritization of therapeutic targets.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Stephen Deutsch, Zachary N. M. Luyo, Jessica A. Burket
Summary: Various ASD risk alleles can lead to impairment of NMDA receptor activation, highlighting the need for the development of specific and selective translational therapeutic NMDA receptor agonists to restore balance.
Article
Medicine, General & Internal
Stephen I. Deutsch, Jessica A. Burket
MEDICAL CLINICS OF NORTH AMERICA
(2023)
Article
Biology
Jessica A. Burket, Mona Matar, Arriyam Fesshaye, Jerrah C. Pickle, Richard A. Britten
Summary: Exposure to He particles can impact cognitive flexibility and social interaction in male rats, leading to deficits in executive functions and possibly affective behavior. These findings suggest that a single behavioral end point may not fully represent the cognitive deficits induced by space radiation.
RADIATION RESEARCH
(2021)
Review
Clinical Neurology
Jessica A. Burket, Maria R. Urbano, Stephen I. Deutsch
CLINICAL NEUROPHARMACOLOGY
(2017)
Review
Clinical Neurology
Stephen I. Deutsch, Jessica A. Burket, Andrew D. Benson, Maria R. Urbano
