Article
Infectious Diseases
Asmaa Amer, Basma Hamdy, Dalia Mahmoud, Mervat Elanany, Magda Rady, Tahani Alahmadi, Sulaiman Alharbi, Sara AlAshaal
Summary: The study isolated, identified, and studied gut bacteria from the American cockroach for their potential antimicrobial activity against multidrug-resistant human pathogens. Results showed that some gut bacteria from the cockroach could antagonize the growth activity of all the tested pathogens, indicating their potential antimicrobial properties for the development of therapeutic drugs in the future. Evaluation and mode of action of these antagonistic gut bacteria against the most affected MDR pathogens were demonstrated using transmission electron microscopy (TEM).
Article
Biochemistry & Molecular Biology
Nan Yan, Shuai Wang, Haotian Gao, Jiaqi Chen, Jiahui Cao, Pengsheng Wei, Xue Li, Ying Yu, Yan Wang, Yalin Niu, Yijie Wang, Shuyuan Liu, Ge Jin
Summary: Aloe emodin, derived from aloe or rhubarb, has various therapeutic effects including anti-renal fibrosis, anti-atherosclerosis, anti-cancer, and neuroprotective effects in ischemic stroke. In this study, aloe emodin was found to improve motor coordination and attenuate visual recognition impairment in HD R6/1 transgenic mice. It achieved this by inhibiting the phosphorylation of CaMKII and TGF-beta 1/Smad signaling, downregulating mutant huntingtin protein levels, and inhibiting neuronal apoptosis. These findings suggest that aloe emodin may be a potential therapeutic option for HD.
Article
Microscopy
Marek Malac, Jesus Alejandro Marin Calzada, Mark Salomons, Darren Homeniuk, Patrick Price, Martin Cloutier, Misa Hayashida, Doug Vick, Sean Chen, Suliat Yakubu, Zhengxu (Darren) Wen, Marcus Leeson, Mohammad Kamal, Jason Pitters, John Kim, Xuanhao Wang, Olivier Adkin-Kaya, Ray Egerton
Summary: NanoMi is an open source electron microscopy platform that offers a modular and flexible design, suitable for various applications such as education and experimental development. It is capable of SEM, TEM, STEM, and ED imaging modes, with an expected resolution of around 10 nanometers.
Article
Chemistry, Multidisciplinary
Wu Zhang, Xiaoke Yang, Juncheng Wang, Jiale Zheng, Ke Yue, Tiefeng Liu, Yao Wang, Jianwei Nai, Yujing Liu, Xinyong Tao
Summary: In this work, a stable sodium metal anode with an NaF-rich interface is proposed, which effectively inhibits dendrite growth and dead sodium. The Na metal anode shows a long-term cycling lifespan and can be readily applied in daily battery assembly.
Article
Chemistry, Physical
Zhihua Huang, Chaoming Yang, John E. Allison, Liang Qi, Amit Misra
Summary: The study investigated the interaction between dislocations and precipitates in a magnesium-neodymium alloy, with differing behavior observed for different types of dislocations and precipitates. It was found that screw dislocations could overcome precipitates through a double cross-slip mechanism, while edge dislocations were unable to bypass precipitates and instead bowed around or cross-slipped.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Materials Science, Multidisciplinary
F. A. Ibrahim, M. H. Habib
Summary: The study created silver vanadate nanosheets using the sol-gel process and found their uniform size distribution and superior electrochromic characteristics. The addition of silver enhanced the crystallinity of V2O5 and improved the compositions' performance, making them suitable for manufacturing electronic devices.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Neurosciences
Marc Espina, Nadia Di Franco, Martina Branas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzman, Silvia Gines
Summary: Increasing evidence suggests that activation of the unfolded protein response (UPR) due to accumulation of misfolded proteins in the endoplasmic reticulum (ER stress) is a key factor in neurodegenerative diseases. In Huntington's disease (HD), disruption of ER-associated degradation pathway and loss of ER protein homeostasis leads to neuronal dysfunction and degeneration. The PERK signaling pathway, in particular, has been found to contribute to memory disturbances and synaptic plasticity deficiencies in HD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Engineering, Electrical & Electronic
Hao Lu, Bin Hou, Ling Yang, Fang Song, Meng Zhang, Mei Wu, Xiaohua Ma, Yue Hao
Summary: In this article, the Ta/Al/Ni/Au and Ti/Al/Ni/Au ohmic contacts and contact formation mechanism on ultrawide bandgap AlN barrier heterostructure were systematically investigated. The results showed that the Ta-based scheme exhibited excellent ohmic contact performance, and the reasons were explained through microscopy observation and electron microscopy analysis.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Multidisciplinary Sciences
Nadezda Varkentina, Yves Auad, Steffi Y. Woo, Alberto Zobelli, Laura Bocher, Jean-Denis Blazit, Xiaoyan Li, Marcel Tence, Kenji Watanabe, Takashi Taniguchi, Odile Stephan, Mathieu Kociak, Luiz H. G. Tizei
Summary: Tracking the lifespan of optical excitations is crucial in understanding the photophysics of materials. In this study, electron spectroscopies were used to explore the creation and decay of excitations in two representative optical materials. The developed cathodoluminescence excitation spectroscopy method allows for imaging energy transfer pathways at the nanometer scale.
Article
Chemistry, Multidisciplinary
Jiake Wei, Qiuhao Xu, Zhi Xu, Wenlong Wang, Sheng Meng, Xuedong Bai
Summary: Through atomic-scale molecular dynamics simulations and dynamic observations, it is found that Coulomb explosion and field evaporation can modify the structures of few-layer graphene nanoribbons. Coulomb explosion splits the nanoribbons into several sheets, while field evaporation breaks them by emitting carbon ions/segments. The shape of the nanoribbons influences the sequence of splitting and breaking. These findings provide fundamental understanding of Coulomb explosion and field evaporation in graphene nanomaterials and suggest potential engineering methods.
Article
Engineering, Mechanical
Xue Fan, Zelong Hu, Wenchao Huang
Summary: This study investigates the stick-slip friction of carbon films with two different crystal structures. In-situ observation and nanofriction tests reveal that the origin of stick and slip is related to shear stress and film deformation. Adhesive deformation results in large stick-slip steps, while ploughing deformation leads to smoother steps. The results from ex-situ tests confirm the findings from in-situ tests.
Article
Biology
Rahma Abd-Elrahim, Mohamed R. A. Tohamy, Mahmoud M. Atia, Mohamed M. A. Elashtokhy, Mohamed A. S. Ali
Summary: This study investigated the effects of seven essential plant oils on the growth of Ralstonia solanacearum both in vitro and in vivo, and explored their potential use as potato seed pieces dressing for controlling bacterial wilt disease. The results showed that anise oil exhibited the strongest inhibitory effect on the growth of Ralstonia solanacearum, followed by thyme, lemongrass, and clove oils. In vivo experiments demonstrated that anise oil significantly reduced disease incidence and severity in potato cultivars and was associated with increased enzyme activity and fresh weight of treated plants.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Food Science & Technology
Fidelis Azi, Zhiyu Li, Peng Xu, Mingsheng Dong
Summary: The study showed that phenolic compounds from kefir fermented soy whey have antibacterial effects against Escherichia coli 0157:H7 and Listeria monocytogenes by permeating the cell membrane, disrupting the cytoplasm, and downregulating key gene expressions. The cells exhibited a resistance response to the phenolics, but the compounds suppressed the expression of translational proteins necessary for cell damage repair.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Anatomy & Morphology
Yu-Jing Zhang, Dong-Yu Chen, Xue-Ting Chao, Zi-Shu Dong, Zong-You Huang, Xia-Lin Zheng, Wen Lu
Summary: This study investigated the antennal sensilla of Copidosomopsis nacoleiae through scanning and transmission electron microscopy. Six types of sensilla were identified on the antennae, with different distribution patterns and potential functions discussed. Future research on host location mechanisms will build upon these observations.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Biochemistry & Molecular Biology
Patrick R. Gleason, Brent L. Nannenga, Jeremy H. Mills
Summary: The study utilized MicroED to analyze the structure of an enzymatic reaction product, identifying an isomer of 24DHPA and establishing its structure model. The MicroED method can provide valuable structural information in a short amount of time.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Electrochemistry
L. Mao, L. Jackson, S. Dunnett
Article
Endocrinology & Metabolism
Rebecca C. Trueman, Claris Diaz, Tracy D. Farr, David J. Harrison, Anna Fuller, Pawel F. Tokarczuk, Andrew J. Stewart, Stephen J. Paisey, Stephen B. Dunnett
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Neurosciences
Marija Fjodorova, Eduardo M. Torres, Stephen B. Dunnett
EXPERIMENTAL NEUROLOGY
(2017)
Article
Cell & Tissue Engineering
David J. Harrison, Victoria H. Roberton, Ngoc-Nga Vinh, Simon P. Brooks, Stephen B. Dunnett, Anne E. Rosser
CELL TRANSPLANTATION
(2018)
Article
Clinical Neurology
Stefano Ferrea, Stefan J. Groiss, Saskia Elben, Christian J. Hartmann, Steve B. Dunnett, Anne Rosser, Carsten Saft, Alfons Schnitzler, Jan Vesper, Lars Wojtecki
JOURNAL OF NEUROLOGY
(2018)
Article
Clinical Neurology
Alexander Maxan, Sarah Mason, Martine Saint-Pierre, Emma Smith, Aileen Ho, Timothy Harrower, Colin Watts, Yen Tai, Nicola Pavese, Julie C. Savage, Marie-Eve Tremblay, Peter Gould, Anne E. Rosser, Stephen B. Dunnett, Paola Piccini, Roger A. Barker, Francesca Cicchetti
ANNALS OF NEUROLOGY
(2018)
Article
Clinical Neurology
Mayke Oosterloo, Emilia Bijlsma, Sander van Kuijk, Floor Minkes, Raymund Roos, C. E. M. de Die-Smulders
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Biochemistry & Molecular Biology
Thomas G. McWilliams, Erica Barini, Risto Pohjolan-Pirhonen, Simon P. Brooks, Francois Singh, Sophie Burel, Kristin Balk, Atul Kumar, Lambert Montava-Garriga, Alan R. Prescott, Sidi Mohamed Hassoun, Francois Mouton-Liger, Graeme Ball, Rachel Hills, Axel Knebel, Ayse Ulusoy, Donato A. Di Monte, Jevgenia Tamjar, Odetta Antico, Kyle Fears, Laura Smith, Riccardo Brambilla, Eino Palin, Miko Valori, Johanna Eerola-Rautio, Pentti Tienari, Olga Corti, Stephen B. Dunnett, Ian G. Ganley, Anu Suomalainen, Miratul M. K. Muqit
Article
Cell & Tissue Engineering
Zoe Noakes, Francesca Keefe, Claudia Tamburini, Claire M. Kelly, Maria Cruz Santos, Stephen B. Dunnett, Adam C. Errington, Meng Li
Review
Neurosciences
Anders Bjorklund, Stephen B. Dunnett
JOURNAL OF PARKINSONS DISEASE
(2019)
Article
Cell Biology
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
Summary: The feeding-related hormone, acyl-ghrelin, has a potential protective effect on dopamine neurons in experimental models of Parkinson's disease. However, its effect on dopaminergic neurons in the 6-OHDA rat medial forebrain bundle lesion model is unknown.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Ludivine S. Breger, Korbinian Kienle, Gaynor A. Smith, Stephen B. Dunnett, Emma L. Lane
BRAIN BEHAVIOR AND IMMUNITY
(2017)
Article
Cell Biology
K. R. Bowles, T. Stone, P. Holmans, N. D. Allen, S. B. Dunnett, L. Jones
CELLULAR SIGNALLING
(2017)
Meeting Abstract
Clinical Neurology
Ana Garcia, Marija Fjudorova, Mariah J. Lelos, Anselme L. Perrier, Marie Michael, Aurore Bugi, Ngoc-Nga Vinh, Meng Li, Stephen B. Dunnett, Anne E. Rosser
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Article
Neurosciences
Paul McNulty, Richard Pilcher, Raviram Ramesh, Renata Necuiniate, Alis Hughes, Daniel Farewell, Peter Holmans, Lesley Jones
JOURNAL OF HUNTINGTONS DISEASE
(2018)