Article
Behavioral Sciences
Michael M. Morgan, Danielle L. Peecher, John M. Streicher
Summary: This study evaluated a novel antagonist (D24M) of the mu-/delta-opioid receptor (MOR/DOR) heterodimer in male rats. The results showed that D24M did not have disruptive side effects and tended to prolong morphine's antinociceptive effects in non-tolerant rats. Further studies are needed to assess the effects of D24M on withdrawal to continuous morphine administration in rats with persistent pain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yanhong Xing, Yao Liu, Mengqiu Deng, Hui-Ping Wang, Mannan Abdul, Fei-Fei Zhang, Zhe Zhang, Jun-Li Cao
Summary: Combining morphine with neuropeptide B23 or neuropeptide W23 can significantly alleviate inflammatory and neuropathic pain, while effectively preventing some adverse effects induced by morphine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Mei-Xiang Zhan, Li Tang, Yun-Fei Lu, Huang-Hui Wu, Zhi-Bin Guo, Zhong-Mou Shi, Chen-Long Yang, Yi-Qing Zou, Fei Yang, Guo-Zhong Chen
Summary: The study investigated the analgesic effect of ulinastatin on acute somatic and visceral pain through formalin and acetic acid-induced writhing test. The results showed that ulinastatin could attenuate acute pain by inhibiting peripheral and spinal inflammatory reactions.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
M. Irene Diaz-Reval, Yolitzy Cardenas, Miguel Huerta, Xochitl Trujillo, Enrique Alejandro Sanchez-Pastor, Maria Eva Gonzalez-Trujano, Adolfo Virgen-Ortiz, M. Gicela Perez-Hernandez
Summary: This study aimed to explore the synergistic effect of a non-steroidal anti-inflammatory drug (NSAID) and a cannabinoid agonist in pain management. The combination of ibuprofen and synthetic cannabinoid WIN 55,212-2 showed a synergistic effect mainly mediated by CB2 receptors, with peripheral receptors playing a relevant role.
Article
Anesthesiology
Diana E. Sepulveda, Daniel P. Morris, Wesley M. Raup-Konsavage, Dongxiao Sun, Kent E. Vrana, Nicholas M. Graziane
Summary: This study demonstrates the effectiveness of CBG in relieving mechanical hypersensitivity caused by cisplatin-induced peripheral neuropathy, but its effects may be limited to specific types of pain.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Endocrinology & Metabolism
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Growing evidence suggests that visceral hypersensitivity and impaired gut barrier function play a crucial role in the development of irritable bowel syndrome (IBS). The APJ system, which modulates the CRF-TLR4-proinflammatory cytokine signaling, is involved in the regulation of visceral sensation and gut permeability. Inhibition of apelinergic signaling may offer a promising therapeutic option for IBS by attenuating the GI changes mediated via AMPK, NO, and opioid signaling.
Article
Chemistry, Multidisciplinary
Daniela Novakova, Karel Kudlacek, Jiri Novotny, Karel Nesmerak
Summary: Gradient elution HPLC with fluorescence detection was used to determine six selected neurotransmitters in rat brain tissue samples. A modified homogenization medium was introduced to increase the stability of the neurotransmitters in the samples. The developed methods were successfully applied to analyze the neurotransmitter levels in rats affected by morphine and/or morphine abstinence.
MONATSHEFTE FUR CHEMIE
(2022)
Editorial Material
Anesthesiology
M. Schaefer
Article
Cardiac & Cardiovascular Systems
Lukas Dehe, Mohammed Shaqura, Michael Nordine, Helmut Habazettl, Petra von Kwiatkowski, Helena Schluchter, Mehdi Shakibaei, Shaaban A. Mousa, Michael Schafer, Sascha Treskatsch
Summary: Myocardial opioid receptors exist in the left ventricle and co-localize with calcium channels. Blockade of the cardiac opioid system by naltrexone improves left ventricular function, reduces cardiac pressure, and enhances cardiac function.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Amir Mohammadzadeh, Peter P. Lakatos, Mihaly Balogh, Ferenc Zador, David arpad Karadi, Zoltan S. Zadori, Kornel Kiraly, Anna Rita Galambos, Szilvia Barsi, Pal Riba, Sandor Benyhe, Laszlo Koles, Tamas Tabi, Eva Szoko, Laszlo G. Harsing, Mahmoud Al-Khrasani
Summary: Animal studies suggest that GlyT inhibitors have potential as analgesics for neuropathic pain, but concerns about adverse effects remain. Combining GlyT-1 and GlyT-2 inhibitors can enhance analgesic effects, with increased CSF glycine content playing a key role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Michael Schafer, Sascha Tafelski
Summary: Following the legalization of cannabis-based medicines and cannabinoids for medical use, there has been a significant rise in prescriptions for cannabis. This article compiles and evaluates clinical evidence on the use of cannabis and cannabinoids for acute and chronic pain, providing guidance for decision-making in clinical practice based on systematic literature reviews and recommendations from health authorities.
Article
Neurosciences
Shaaban A. Mousa, Mohammed Shaqura, Baled I. Khalefa, Li Li, Mohammed Al-Madol, Sascha Treskatsch, Michael Schaefer
Summary: The study demonstrated a preference for the expression of CRF-R2 over CRF-R1 in the dorsal horn of the rat spinal cord, and both CRF and CRF-R2 agonists elicited potent dose-dependent antinociceptive effects through the spinal CRF-R2 receptors. This suggests that CRF or CRF-R2 agonists inhibit somatic inflammatory pain predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Anesthesiology
Erika Schulte, Claudia Spies, Claudia Denke, Joerg J. Meerpohl, Norbert Donner-Banzhoff, Frank Petzke, Ralph Hertwig, Michael Schafer, Odette Wegwarth
Summary: Strong opioids used by patients with chronic noncancer pain not only have physical side effects but also significant psychological effects. Most patients have received information about opioid effects, but more discussions about discontinuation of opioid therapy are needed.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anatomy & Morphology
Lukas Dehe, Shaaban A. Mousa, Noureddin Aboryag, Mohammed Shaqura, Antje Beyer, Michael Schaefer, Sascha Treskatsch
Summary: This study provides the first evidence of local expression of MR, 11 beta-HSD2, and aldosterone with its processing enzyme CYP11B2 in neurons of the cardiac autonomic nervous system, suggesting a possible modulatory role of the mineralocorticoid system on the endogenous neuronal activity on heart performance.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Medicine, General & Internal
Erika Schulte, Frank Petzke, Claudia Spies, Claudia Denke, Michael Schaefer, Norbert Donner-Banzhoff, Ralph Hertwig, Odette Wegwarth
Summary: This study, based on physician self-reporting, reveals that some physicians experience negative emotions when faced with a patient's request for an increase in opioid dosage, which may lead to inappropriate prescribing of strong opioids. Self-awareness of physician emotions is crucial for ensuring responsible, guideline-based long-term opioid prescriptions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Shaaban A. Mousa, Baled I. Khalefa, Mohammed Shaqura, Mohammed Al-Madol, Sascha Treskatsch, Michael Schaefer
Summary: This study found that CRF-R1 in opioid-peptide-containing brain areas plays an important role in the modulation of inflammatory pain and may be a useful therapeutic target for its control.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Lukas Dehe, Shaaban A. Mousa, Mohammed Shaqura, Mehdi Shakibaei, Michael Schaefer, Sascha Treskatsch
Summary: This study examined the effects of chronic volume overload on myocardial opioid receptors and the inflammatory response in the failing heart. The results showed that opioid receptor blockade by naltrexone improved left ventricular function and reduced inflammatory cytokine expression. This suggests that antagonism of the myocardial opioid system can improve cardiac function and modulate the inflammatory response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Shaaban A. Mousa, Lukas Dehe, Noureddin Aboryag, Mohammed Shaqura, Antje Beyer, Michael Schaefer, Sascha Treskatsch
Summary: This study demonstrates the expression of glucocorticoid receptors (GR) in relation to the parasympathetic and sympathetic innervations of the heart. GRs were found to be co-expressed with the parasympathetic neuronal marker VAChT and the sympathetic neuronal marker TH, suggesting a functional role of cardiac GR in modulating the cardiac autonomic nervous system.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
David a. Karadi, Anna Rita Galambos, Peter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihaly Balogh, Kornel Kiraly, Pal Riba, Nariman Essmat, Edina Szucs, Sandor Benyhe, Zoltan V. Varga, Eva Szoko, Tamas Tabi, Mahmoud Al-Khrasani
Summary: The study investigates the antiallodynic effect of telmisartan and losartan, two AT1 blockers, in combination with morphine for neuropathic pain management. The combination therapy shows promising results in improving pain and delaying morphine tolerance development. Further studies are needed to analyze the effect of each component in the combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jan D. Wandrey, Joanna Kastelik, Thomas Fritzsche, Claudia Denke, Michael Schaefer, Sascha Tafelski
Summary: Patients with refractory neuralgia of cranial nerves may benefit from invasive therapy with local anesthetics. Transcranial direct current stimulation (tDCS) prior to local anesthetic infiltration may prolong pain response, but results may be influenced by placebo effects and high drop-out rates, warranting further investigation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cell Biology
Sascha Tafelski, Jan D. D. Wandrey, Mohammed Shaqura, Xueqi Hong, Antje Beyer, Michael Schaefer, Shaaban A. A. Mousa
Summary: The activation of MR and GR receptors on peripheral sensory neurons can modify pain perception through direct and indirect pathways. The expression of MR and GR was examined in sensory neuron subpopulations in human and rat peripheral nerves. MR showed colocalization with CGRP, TRPV1, and Nav1.8 in both human and rat nerve tissue, while GR primarily colocalized with NF200 positive mechanoreceptive fibers. Intrathecal administration of GR agonist decreased mechanical hyperalgesia, while MR agonist increased it in rats. These findings suggest a translational approach to sensory modulation through MR and GR activation.
Article
Anesthesiology
Jan D. Wandrey, Michael Schaefer, Joachim Erlenwein, Sascha Tafelski
Summary: This study aims to assess the current state of perioperative anesthesiological pain management for patients with phantom limb pain. It reveals the unmet need for specialized pain treatment during this period and suggests further research questions.