Article
Biochemistry & Molecular Biology
Lu-Yuan Peng, Hai-Tao Shi, Yue-Rong Tan, Si-Yang Shen, Peng-Fei Yi, Hai-Qing Shen, Ben-Dong Fu
Summary: The study found that baicalin protected against APEC infection by modulating gut microbiota, increasing short chain fatty acid (SCFA) production, especially acetate. Acetate may circulate to the lungs to activate FFAR2 to defend against APEC infection.
Article
Multidisciplinary Sciences
Sireesh Kumar Teertam, Prakash Babu Phanithi
Summary: The study found that the expression of Sirt1, Beclin-1, Atg-3, 5, 7, 12-5, and Lc3-II/I were upregulated in stroke patients. Immunohistochemistry results showed increased immunoreactivity of Sirt1, Beclin-1, Atg-7, Lc3-I/II, and cleaved caspase-3 in stroke brains.
Article
Clinical Neurology
Iris Muehlen, Maximilian Sprugel, Philip Hoelter, Stefan Hock, Michael Knott, Hagen B. Huttner, Stefan Schwab, Bernd Kallmunzer, Arnd Doerfler
Summary: This study evaluated two commonly used automated computed tomography perfusion software applications and found that by adjusting the relative cerebral blood flow thresholds, comparable results with reliable information on the follow-up infarct volume after complete recanalization can be obtained. Keeping the software specific default settings means being more inclusive in patient selection but sacrificing the highest possible accuracy in the estimation of the infarct volume.
Article
Behavioral Sciences
Bin Feng, Sansan Jia, Liya Li, Jiajia Wang, Fang Zhou, Xingchun Gou, Qiang Wang, Lize Xiong, Yi Zeng, Haixing Zhong
Summary: This study found that TAT-LBD-Ngn2 could significantly improve long-term learning and memory by promoting neurogenesis in the hippocampus, suggesting it may be an appealing candidate for treating poststroke neurocognitive disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Virology
Zhenqiao Wei, Rui Gao, Zhen Sun, Wen Yang, Qi He, Chenhui Wang, Jingxiang Zhang, Xiaochang Zhang, Liang Guo, Shengqi Wang
Summary: This study reveals that baicalin, derived from Scutellaria baicalensis, can protect lung alveolar epithelial cells from H1N1-induced pyroptosis, an inflammatory form of programmed cell death, by inhibiting the caspase-3/GSDME pathway. This is the first demonstration of the important role of baicalin in antiviral activity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Changxiang Li, Conglu Sui, Wei Wang, Juntang Yan, Nan Deng, Xin Du, Fafeng Cheng, Xiaona Ma, Xueqian Wang, Qingguo Wang
Summary: This study showed that baicalin protects neurons from oxidative stress, inflammation, and apoptosis by promoting astrocytes to release more BDNF. The neuroprotective effect is mainly mediated through the BDNF-TrkB pathway and downstream signaling regulators PI3K/Akt and MAPK/ERK1/2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yingying Jiang, Qingying Liu, Yumei Zhao, Chunyang Wang, Ming Sun
Summary: Cerebral ischemia leads to excitotoxicity and neural apoptosis. In this study, the effects of chemogenetic inhibition or activation of glutamatergic neurons in the vCA1 region on sequelae induced by cerebral ischemia were investigated. The results showed that inhibition of vCA1 pyramidal neurons alleviated neurological deficits, pain perception, anxiety, and depression, while activation had limited effects. Additionally, overexpression of CREB protein in vCA1 pyramidal neurons improved the dysfunction induced by ischemic stroke by upregulating BDNF.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Matteo Haupt, Mathias Baehr, Thorsten R. Doeppner
Summary: Lithium shows potential neuroprotective effects in neurological diseases by regulating apoptosis, inflammation, and neurogenesis pathways, offering promising therapeutic strategies for clinical trials.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Bing Li, Ying Wang, Hao Gu, Yanan Yu, Pengqian Wang, Jun Liu, Yingying Zhang, Yinying Chen, Qikai Niu, Bo Wang, Qiong Liu, Shuang Guan, Yanda Li, Huamin Zhang, Zhong Wang
Summary: Combination therapy with increased efficacy and reduced toxicity is crucial for treating complex diseases. This study presents a strategy called Driver-induced Modular Screening (DiMS) to elucidate the additive mechanisms of Baicalin (BA) and Jasminoidin (JA) on cerebral ischemia (CI) therapy. The study identifies driver genes and modules and explores their neuroprotective roles. The findings provide new insights into the synergistic mechanisms of combination therapy and screening multi-targeted drugs for complex diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jing Wang, Quanguang Zhang, Yujiao Lu, Yan Dong, Krishnan M. Dhandapani, Darrell W. Brann, Robert K. Yu
Summary: The study demonstrates that ganglioside GD3 regulates phagocytosis by microglia in an ischemic stroke model. The impaired phagocytic capacity of GD3S-KO microglia after GCI may contribute to delayed neuronal death.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Wen-Xia Zheng, Wen-Qi He, Qian-Rui Zhang, Jin-Xin Jia, Sheng Zhao, Fang-Jian Wu, Xiao-Lu Cao
Summary: Baicalin can reduce the activity of the NLRP3 inflammasome through activation of the AMPK signaling pathway, thereby inhibiting cerebral ischemia-reperfusion injury.
Article
Plant Sciences
Tian Xu, Xueqian Wang, Chongyang Ma, Jing Ji, Wenxiu Xu, Qi Shao, Xuejing Liao, Ying Li, Fafeng Cheng, Qingguo Wang
Summary: Baicalin has potential therapeutic effects in preventing cerebral ischemia by reducing neurological injury and inhibiting inflammatory responses through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xinxin Li, Shuling Li, Chun Ma, Tieshu Li, Lihua Yang
Summary: This study optimized a nanocarrier formulation for nose-to-brain delivery of neuroprotective agents. The results showed that the nanocarriers could effectively deliver the agents to the brain, reducing delivery to the peripheral circulation. By modifying the surface of the nanoparticles, the bioavailability of the agents was improved, and neuroprotective effects against cerebral ischemia were observed.
Article
Hematology
Han Bai, Junpeng Ma, Weikang Mao, Xuan Zhang, Yijun Nie, Jingcan Hao, Xiaorui Wang, Hongyu Qin, Qiqi Zeng, Fang Hu, Xin Qi, Xiaobei Chen, Dong Li, Binghong Zhang, Bingyin Shi, Chengsheng Zhang
Summary: A study sequenced the TCR of asymptomatic individuals infected with SARS-CoV-2 and found significant TCR preferences in this group. This finding provides insights into the immunopathogenesis of COVID-19 and may aid in the development of novel therapeutic strategies for SARS-CoV-2 infection.
BLOOD CELLS MOLECULES AND DISEASES
(2022)
Article
Physics, Multidisciplinary
DongDong Chen, Zhi Xu, XiaoRui Wang, Mei Wang, ZhongZhou Du
Summary: In this letter, a novel hierarchical simulated annealing of erosion (HSAE) method is proposed to address the high computational cost issue in stochastic reconstruction techniques based on correlation functions. The HSAE method achieves significant improvements in both accuracy and computational efficiency, although there is still room for further enhancements.
Article
Engineering, Electrical & Electronic
Xin Sun, Changrui Chen, Xiaorui Wang, Junyu Dong, Huiyu Zhou, Sheng Chen
Summary: This study proposes a lightweight neural network approach based on Gaussian dynamic convolution (GDC) for single-image segmentation. The GDC method efficiently aggregates contextual information to achieve superior segmentation results, and demonstrates potential and generality in common semantic segmentation.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Sheng Miao, Liang Dong, Xiaorui Wang
Summary: This paper proposes a method for multi-target identification and location in an arbitrary structure. The method uses geometric dilution of precision value for multi-target judgment and utilizes linear constrained minimum variance beam former and time difference of arrival algorithm for target localization. Simulation results show that the proposed method significantly improves the localization performance and has better stability.
INTERNATIONAL JOURNAL OF PATTERN RECOGNITION AND ARTIFICIAL INTELLIGENCE
(2022)
Article
Computer Science, Information Systems
Xiaorui Wang, Dongdong Chen
Summary: With the maturation of space laser communication technologies and the development of deep-space exploration technologies, deep-space optical network (DSON) is expected to become an important foundation and inevitable development trend of future deep-space communication. In this paper, a DSON topology structure based on flat wireless mesh network (FWMN) is presented, and a Routing Algorithm based on ant colony algorithm (RA-ACA) is proposed to improve the robustness of DSON and realize load balancing. Simulation results demonstrate the advantages of the proposed RA-ACA compared with traditional ant colony algorithm (TACA) for DSON.
JOURNAL OF COMMUNICATIONS AND NETWORKS
(2022)
Article
Computer Science, Cybernetics
Xiaorui Wang, Ronggang Zhou
Summary: This article validates the impact of expectation and disconfirmation on user experience satisfaction and behavioral intention through two studies on mobile e-banking apps. It also reveals the moderating effect of expectation levels in predicting user satisfaction and behavioral intention.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Review
Food Science & Technology
Xuhan Yang, Zhonglu Niu, Xiaorui Wang, Xiaoming Lu, Jinyue Sun, M. Carpena, M. A. Prieto, Jesus Simal-Gandara, Jianbo Xiao, Chao Liu, Ningyang Li
Summary: Pomegranate is a delicious fruit with beautiful flowers, rich in bioactive compounds that have benefits for human health. Different parts of the pomegranate contain distinct bioactive components, which possess antioxidant, anti-inflammatory, and anti-cancer properties, among others. It is widely used in various fields such as food, health care, and medicine.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biophysics
Gaowa Xing, Yuting Shang, Xiaorui Wang, Haifeng Lin, Shulang Chen, Qiaosheng Pu, Ling Lin
Summary: In this study, a finger-actuated microfluidic biosensor was developed for rapid and sensitive detection of foodborne pathogens. The biosensor integrated one-pot CRISPR/Cas12a with recombinase aided amplification (RAA), and could be operated without the need for an external driving device. The results showed that the biosensor had high sensitivity and accuracy, making it suitable for point-of-care testing in resource-constrained settings.
BIOSENSORS & BIOELECTRONICS
(2023)
Correction
Oncology
Jingxia Han, Jing Meng, Shuang Chen, Xiaorui Wang, Shan Yin, Qiang Zhang, Huijuan Liu, Rong Qin, Zhongwei Li, Weilong Zhong, Chao Zhang, Heng Zhang, Yuanhao Tang, Wanfeng Gao, Xiaoyun Zhang, Lan Yang, Yanrong Liu, Hong-gang Zhou, Tao Sun, Cheng Yang
Article
Environmental Sciences
Xiaorui Wang, Hongyue Wu, Kunlun Yang, Peng Gu, Yu Zheng, Manman Li, Yonggui Wu, Hengfeng Miao
Summary: This study assessed the hepatotoxicity of sludge leachate on zebrafish and described the underlying mechanism. The results showed that the leachate induced oxidative stress and caused liver damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Genetics & Heredity
Xiaorui Wang, Zhihou Guo, Furong Yan
Summary: This article reviews the role of RNA epigenetics in chronic lung diseases, emphasizing its crucial role in disease development. Exploring the mechanisms of RNA epigenetics may lead to the development of new biomarkers and therapeutic strategies.
Article
Dermatology
Xiaorui Wang, Xia Li, Jiying Zhang
Summary: This study conducted a meta-analysis to assess the effect of refined nursing interventions in the operating room on surgical-site wound infections in patients undergoing lung cancer surgery. The results showed that refined nursing interventions significantly reduced the incidence of wound infections and shortened the length of hospital stay. However, more high-quality studies are needed to confirm these findings.
INTERNATIONAL WOUND JOURNAL
(2023)
Proceedings Paper
Acoustics
Ying Zhang, Peng Yang, Jinba Xiao, Ye Bai, Hao Che, Xiaorui Wang
Summary: This study presents K-Converter, a simple system for voice conversion that can disentangle timbre, pitch, and content information without manual supervision or adversarial training. The proposed system shows promising results in speech naturalness, timbre similarity, and robustness to comparisons.
2022 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP)
(2022)
Proceedings Paper
Acoustics
Yi Zou, Pei Zou, Yi Zhao, Kaixiang Zhang, Ran Zhang, Xiaorui Wang
Summary: This paper proposes a melody generation framework called MELONS, which is based on a graph representation of music structure. MELONS uses a multi-step generation method with transformer-based networks to tackle the challenges of generating a full-song melody with clear long-term structure. Experimental results demonstrate that MELONS can generate structured melodies with high quality and rich contents.
2022 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP)
(2022)
Proceedings Paper
Acoustics
Chenxing Li, Yang Wang, Feng Deng, Zhuo Zhang, Xiaorui Wang, Zhongyuan Wang
Summary: This paper proposes a Conformer-based network, named EAD-Conformer, to enhance the performance of multi-task audio source separation. By employing encoder-attention-decoder modeling, the network effectively captures both local and global information, resulting in improved separation performance. Experimental results demonstrate the effectiveness of EAD-Conformer, outperforming several well-known models.
2022 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP)
(2022)
