期刊
BRAIN RESEARCH BULLETIN
卷 85, 期 3-4, 页码 81-88出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2011.03.020
关键词
Deep brain stimulation; Epilepsy; Anterior nucleus of thalamus; Treatment
资金
- National Natural Science Foundation of China [30870884]
- Shandong Provincial Outstanding Medical Academic Professional Program
Given the tremendous success of deep brain stimulation (DBS) for the treatment of movement and neuropsychiatric disorders, clinicians have begun to open up to the possible use of electrical stimulation for the treatment of patients with uncontrolled seizures. DBS of various neural targets has been investigated in clinical studies and animal studies, including the anterior nucleus of thalamus (ANT), cerebellum, hippocampus, subthalamic nucleus (STN), centromedian nucleus of the thalamus (CMT), caudate nucleus (CN). Recently, a large and multicenter trial (SANTE: Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy) was conducted and subsequently with encouraging results, making ANT the most well-established target for DBS in the treatment of epilepsy to date. Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target. (C) 2011 Elsevier Inc. All rights reserved.
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