Review
Cell Biology
Xiu-Quan Wu, Ning Su, Zhou Fei, Fei Fei
Summary: This review summarizes the structural features, signaling pathways, and roles of Homer proteins in ischemic and traumatic insults to the central nervous system. Upregulating Homer1a or downregulating Homer1b/c may have neuroprotective effects in secondary brain injuries. Homer also plays an important role in the formation of photoreceptor synapses. These findings support the future development of therapeutic targets or gene therapies based on Homer proteins for ischemic and traumatic brain injuries and retinal disorders.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Giuseppe De Simone, Mariateresa Ciccarelli, Alessia Castiello, Benedetta Mazza, Licia Vellucci, Annarita Barone
Summary: Schizophrenia is a severe mental illness characterized by alterations in synaptic plasticity and functional connectivity. Antipsychotics, the cornerstone of pharmacological treatment for schizophrenia, have been found to affect synaptic architecture and reshape neuronal functional units. Different antipsychotics may lead to different patterns of co-activation in brain regions.
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Annarita Barone, Licia Vellucci
Summary: Schizophrenia is a severe psychiatric illness affecting millions of people worldwide, and it is characterized by synaptic plasticity and brain connectivity. Antipsychotics, the primary pharmacological treatment, act on dopamine D2 receptors while also involving non-canonical mechanisms such as the involvement of dopamine transporter and chaperone effects. These mechanisms expand the understanding of dopamine's role in schizophrenia therapy and may have implications for the treatment of treatment-resistant schizophrenia (TRS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tamara Jankovic, Petra Dolenec, Jelena Rajic Bumber, Nika Grzeta, Jasna Kriz, Gordana Zupan, Kristina Pilipovic
Summary: Traumatic brain injury (TBI) is a disabling disorder and a major cause of death and disability worldwide. Studies have shown differences in TDP-43 expression patterns following single versus repetitive TBI, with pathological changes in the hippocampal TDP-43 expression only observed after single moderate TBI. This suggests that different types of brain trauma may lead to diverse pathophysiological changes related to TDP-43 protein and microglial reaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maxon Knott, Laura B. Ngwenya, Erika A. Correll, Judy Bohnert, Noah J. Ziemba, Emily Allgire, Tracy Hopkins, Jennifer L. McGuire
Summary: Traumatic brain injury (TBI) affects over 69 million people annually worldwide, and those with pre-existing depression have worse recovery. Commonalities between TBI and depression include volume changes, myelin disruption, changes in proliferation, and changes in glutamatergic signaling. The study using the WKY rat model revealed exaggerated myelin loss and baseline deficits in proliferation after TBI, as well as differing glutamate receptor subunit changes between WKY and Wistar rats after LFPI. These findings could lead to potential therapeutic targets for individuals with pre-existing depression and poor recovery after TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mason Stillman, Jonathan D. Lautz, Richard S. Johnson, Michael J. MacCoss, Stephen E. P. Smith
Summary: Neurons encode information by modifying synaptic protein complexes, and Homer1's binding to mGlu5 and Shank3 changes in response to synaptic activity. A study in the cerebral cortex found an activity-dependent protein network involving mGlu5, Shank2 and 3, and Homer1-3, with only mGlu5 and Shank3 significantly reduced after neuronal depolarization.
SCIENTIFIC REPORTS
(2022)
Review
Nutrition & Dietetics
Matthew Boyko, Benjamin F. Gruenbaum, Anna Oleshko, Igor Merzlikin, Alexander Zlotnik
Summary: Traumatic brain injury (TBI) has long-term impacts on cognitive and mental functioning and significantly decreases quality of life. The blood-brain barrier (BBB) plays a crucial role in regulating glutamate levels in the brain. Studies have shown that reducing excess glutamate can help treat post-TBI depression, anxiety, and aggression. This article evaluates the role of dietary glutamate in the development of depression after TBI.
Article
Neurosciences
Kenneth R. Myers, Yanjie Fan, Patrick McConnell, John A. Cooper, James Q. Zheng
Summary: Dendritic spines are small actin-rich protrusions essential for the formation of functional circuits in the mammalian brain. The formation and morphology of spines are regulated by the remodeling of the actin cytoskeleton, in which capping protein (CP) and proteins containing capping protein interaction (CPI) motifs play important roles.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Marcell Miski, Bence Mark Keomley-Horvath, Dorina Rakoczi Megyerine, Attila Csikasz-Nagy, Zoltan Gaspari
Summary: This study used large-scale stochastic simulations of protein binding events to predict the presence and distribution of PSD complexes. The results show that the relative ratio of emerging protein complexes is sensitive to subtle changes in protein abundances, highlighting the importance of explicit simulations in understanding protein availability and complex formation.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ali Mahmoudi, Sahar Heydari, Yuliya V. Markina, George E. Barreto, Amirhossein Sahebkar
Summary: This study explores the role of statins in modulating proteins and pathways related to traumatic brain injury (TBI) using system pharmacology. The results suggest that statins may target key genes involved in inflammation and apoptosis, supporting their potential as a therapeutic agent for TBI.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Benjamin F. N. Campbell, Antje Dittmann, Birgit Dreier, Andreas Plueckthun, Shiva K. Tyagarajan, John R. Huguenard
Summary: Neuroscience currently relies on antibodies for studying synaptic proteins, but the availability of reagents for studying the inhibitory synaptic protein gephyrin is limited. In this study, a DARPin library was screened against gephyrin mutants to generate a diverse set of DARPin clones with different binding modes. These anti-gephyrin DARPins were validated for identifying and characterizing gephyrin clusters, leading to the discovery of previously overlooked clusters and providing insights into gephyrin's nonsynaptic functions.
Review
Neurosciences
Xavier L. Warnet, Helle Bakke Krog, Oscar G. Sevillano-Quispe, Hanne Poulsen, Magnus Kjaergaard
Summary: The C-terminal domains (CTDs) of NMDA receptors play a multifaceted role in synaptic plasticity, acting as modifiers of channel function, regulators of cellular location and abundance, and signaling scaffold controllers of downstream signaling output.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Weijie Wang, Xiaotian Zhang, Ruixing He, Shaoxun Li, Dazhao Fang, Cong Pang
Summary: This study found that 40 Hz light flicker can improve cognitive impairment after traumatic brain injury (TBI) by decreasing postsynaptic transmission in the CA1 region of the hippocampus. These findings provide new insights into the relationship between oscillatory activity in the hippocampus and cognitive deficits in TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Chenglin Liu, Xiaofeng Sun, Yifan Cai, Di Li, Bing Li, Rong Gao, Li Zhang, Gang Chen
Summary: This study found that pramipexole could play a protective role after traumatic brain injury (TBI) by inhibiting necroptosis, thereby improving the prognosis of TBI rats.
NEUROSCIENCE LETTERS
(2022)
Article
Pharmacology & Pharmacy
Cindy Santiago-Castaneda, Saul Huerta de la Cruz, Christopher Martinez-Aguirre, Sandra Adela Orozco-Suarez, Luisa Rocha
Summary: This study demonstrates that orally administered cannabidiol (CBD) can reduce the excessive release of glutamate caused by traumatic brain injury (TBI) and facilitate functional recovery. CBD pretreatment significantly reduces glutamate concentration and improves survival rate and body weight gain. Long-term treatment also shows a reduction in glutamate concentration and improvement in sensorimotor function.
Article
Cell Biology
Tao Chen, Shu-Hui Dai, Zhi-Quan Jiang, Peng Luo, Xiao-Fan Jiang, Zhou Fei, Song-Bai Gui, Yi-Long Qi
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2017)
Correction
Biochemistry & Molecular Biology
Cheng Peng, Wei Rao, Lei Zhang, Kai Wang, Hao Hui, Li Wang, Ning Su, Peng Luo, Ye-lu Hao, Yue Tu, Sai Zhang, Zhou Fei
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Shu-Hui Dai, Tao Chen, Xia Li, Kang-Yi Yue, Peng Luo, Li-Kun Yang, Jie Zhu, Yu-Hai Wang, Zhou Fei, Xiao-Fan Jiang
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Neurosciences
Yuefan Yang, Peng Luo, Haoxiang Xu, Shuhui Dai, Wei Rao, Cheng Peng, Wenke Ma, Jiu Wang, Hongyu Xu, Lei Zhang, Sai Zhang, Zhou Fei
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Xin Li, Haoxiang Xu, Tao Lei, Yuefan Yang, Da Jing, Shuhui Dai, Peng Luo, Qiaoling Xu
Frontiers in Neuroscience
(2017)
Article
Biochemistry & Molecular Biology
Yang Yu, Xiuquan Wu, Jingnan Pu, Peng Luo, Wenke Ma, Jiu Wang, Jialiang Wei, Yuanxin Wang, Zhou Fei
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Cell Biology
Cheng Peng, Wei Rao, Lei Zhang, Fan Gao, Hao Hui, Kai Wang, Shuhui Dai, Yuefan Yang, Peng Luo, Yihui Ma, Wenke Ma, Xinguang Yu, Zhou Fei
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Neurosciences
Xiuquan Wu, Peng Luo, Wei Rao, Shuhui Dai, Lei Zhang, Wenke Ma, Jingnan Pu, Yang Yu, Jiu Wang, Zhou Fei
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Tao Chen, Shu-Hui Dai, Xia Li, Peng Luo, Jie Zhu, Yu -Hai Wang, Zhou Fei, Xiao-Fan Jiang
Article
Neurosciences
Jialiang Wei, Xiuquan Wu, Peng Luo, Kangyi Yue, Yang Yu, Jingnan Pu, Lei Zhang, Shuhui Dai, Donghui Han, Zhou Fei
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Cell Biology
Peng Luo, Xin Li, Xiuquan Wu, Shuhui Dai, Yuefan Yang, Haoxiang Xu, Da Jing, Wei Rao, Hongyu Xu, Xiangyu Gao, Zhou Fei, Hongbing Lu
CELL DEATH & DISEASE
(2019)
Article
Oncology
Haoxiang Xu, Xin Li, Xiuquan Wu, Yuefan Yang, Shuhui Dai, Tao Lei, Da Jing, Peng Luo, Erping Luo
EXPERIMENTAL CELL RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Xin Li, Xiuquan Wu, Peng Luo, Lize Xiong
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
FRONTIERS IN NEUROLOGY
(2020)
Article
Neuroimaging
Bin Yang, Bing Li, Canhua Xu, Shijie Hu, Meng Dai, Junying Xia, Peng Luo, Xuetao Shi, Zhanqi Zhao, Xiuzhen Dong, Zhou Fei, Feng Fu
NEUROIMAGE-CLINICAL
(2019)