Review
Biochemistry & Molecular Biology
Alice Jacquens, Edward J. Needham, Elisa R. Zanier, Vincent Degos, Pierre Gressens, David Menon
Summary: Head trauma is a common cause of disability in young adults, and cranial trauma in children has particularities in terms of epidemiology, mechanism, and physiopathology. The long-term repercussions of head trauma can be attributed to chronic neuroinflammation, a complex process involving various actors. Numerous studies have explored different anti-inflammatory therapies for traumatic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Clement Delage, Toufik Taib, Celia Mamma, Dominique Lerouet, Valerie C. Besson
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, leading to inflammatory responses, white matter injuries, and neurodegenerative pathologies. The consequences of TBI and pharmacological responses vary with age, emphasizing the need for age-specific approaches in therapy development.
Article
Anesthesiology
Federico Moro, Francesca Fossi, Aurora Magliocca, Rosaria Pascente, Eliana Sammali, Federico Baldini, Daniele Tolomeo, Edoardo Micotti, Giuseppe Citerio, Nino Stocchetti, Francesca Fumagalli, Sandra Magnoni, Roberto Latini, Giuseppe Ristagno, Elisa R. Zanier
Summary: In a mouse model, acute administration of argon gas (iAr) significantly accelerates sensorimotor recovery, improves cognitive deficits, and reduces white matter damage after TBI. iAr also decreases brain edema and neuroinflammation, while increasing ramified cells and the M2-like marker YM1 in microglia.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Clinical Neurology
Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Nyam-Erdene, Szu-Yi Chou, Luc Buee, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf
Summary: TBI causes significant brain anatomopathological damages which can be addressed by a synergistic biotherapy such as human platelet lysate. Its therapeutic potential was tested in in vitro and in vivo TBI models, showing promising results in improving motor function and mitigating neuroinflammation and oxidative stress. The data strongly support that human platelet lysate is a reliable and effective source of neurorestorative factors for brain trauma treatment.
Review
Chemistry, Medicinal
Julio J. Secades
Summary: Citicoline, a neuroprotective drug, has the potential to accelerate recovery of consciousness and improve the outcomes of patients with TBI. It could play a role in the management of TBI with its excellent safety profile.
Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Daniel T. Laskowitz, David W. Van Wyck
Summary: The lack of targeted therapies for traumatic brain injury (TBI) is due to difficulties in animal modeling and clinical trial design. A reverse translational approach that focuses on translating endogenous mechanisms known to influence outcomes after TBI to develop druggable targets is proposed.
Article
Multidisciplinary Sciences
Ashfaq Ahmed Khan Malik, Waqas Ahmad, Farhan Younas, Haroon Badshah, Shatha Alharazy, Shafiq Ur Rehman, Muhammad Imran Naseer, Osama Yousef Muthaffar, Rehmatullah Achakzai, Ikram Ullah
Summary: Traumatic brain injury (TBI) is a major cause of mortality and a significant public health concern. This study investigated the neuroprotective effects of Troxerutin, a natural flavonoid, in a closed brain injury mouse model. The results demonstrated that pre-treatment with Troxerutin improved neurological functions, reduced brain edema, enhanced cognitive behavior, decreased Reactive Oxygen Species (ROS), and improved neuronal morphology and survival.
Article
Neurosciences
Jie Zhu, Xiaolong Lin, Chen Chen, Helian Tan, Yanping Gao, Di Li, Gang Chen
Summary: WNK3 is identified as a key regulator of chloride ion transport and neuronal survival in various cell types. The study revealed that overexpression of WNK3 ameliorated neuronal apoptosis, blood-brain barrier disruption, brain edema, and neurological deficits following traumatic brain injury, suggesting a potential neuroprotective role of WNK3 in TBI.
Article
Neurosciences
Xueshi Chen, Cheng Gao, Ya'nan Yan, Zhiqi Cheng, Guang Chen, Tongyu Rui, Chengliang Luo, Yuan Gao, Tao Wang, Xiping Chen, Luyang Tao
Summary: Traumatic brain injury (TBI) is a major global cause of death and disability, with various forms of cell death involved including ferroptosis. This study investigated the effect of the FDA approved drug ruxolitinib (Ruxo) on ferroptosis post-TBI, demonstrating its significant inhibitory effect on ferroptosis and neuroprotective effects on TBI-induced neurological deficits.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Yu Liu, Zongren Zhao, Jianqiang Guo, Yuanhao Ma, Jing Li, Huanhuan Ji, Zhongjun Chen, Jinyu Zheng
Summary: The study found that anacardic acid has an anti-ferroptosis effect in traumatic brain injury, improving nerve function and cognitive impairment. Additionally, anacardic acid mitigated tissue defects, blood-brain barrier disruption, and neurodegeneration, while also displaying anti-inflammatory properties.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Marta Celorrio, James Rhodes, Sangeetha Vadivelu, McKenzie Davies, Stuart H. Friess
Summary: Preclinical trials testing the neuroprotective efficacy of N-acetylcysteine (NAC) against a secondary hypoxic insult after traumatic brain injury (TBI) demonstrated short and long-term neuropathological evidence of neuroprotection, but no detectable differences in long-term behavioral assessments between sham controls and injured mice were found.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Engineering, Biomedical
Feng Qian, Yuhan Han, Zhengzhong Han, Deyun Zhang, Long Zhang, Gang Zhao, Shanshan Li, Guoliang Jin, Rutong Yu, Hongmei Liu
Summary: A hydrogel embedded with curcumin was developed to reduce excess reactive oxygen species in damaged brain tissue, promoting neuron regeneration and recovery. The hydrogel effectively responded to the traumatic brain injury surgical environment, depleting ROS levels and reducing brain edema while promoting nerve regeneration with strong anti-inflammatory effects.
Review
Cell Biology
Xiu-Quan Wu, Ning Su, Zhou Fei, Fei Fei
Summary: This review summarizes the structural features, signaling pathways, and roles of Homer proteins in ischemic and traumatic insults to the central nervous system. Upregulating Homer1a or downregulating Homer1b/c may have neuroprotective effects in secondary brain injuries. Homer also plays an important role in the formation of photoreceptor synapses. These findings support the future development of therapeutic targets or gene therapies based on Homer proteins for ischemic and traumatic brain injuries and retinal disorders.
NEURAL REGENERATION RESEARCH
(2022)