Article
Chemistry, Analytical
Yasmin Alhamoud, Yingying Li, Haibo Zhou, Ragwa Al-Wazer, Yiying Gong, Shuai Zhi, Danting Yang
Summary: A new label-free electrochemical biosensor based on three-dimensional reduced graphene oxide/gold nanoparticles/aptamer was constructed for OTA detection, showing excellent sensitivity and reproducibility. The aptasensor exhibited a broad linear response and low LOD, making it applicable for OTA detection in real samples with economical, specific, susceptible, fast, easy, and transportable merits.
Article
Electrochemistry
Laia Anvari, Sayed Mehdi Ghoreishi, Kamyar Khoshnevisan, Mohammad Reza Ganjali, Farnoush Faridbod
Summary: Progress in highly sensitive analytical methods for illicit drugs poses serious challenges. Electrochemical aptamer-based sensors are considered potent analytical tools due to their portability, quick response, sensitivity, and simplicity. In this study, a novel aptasensor using electrochemical impedance spectroscopy (EIS) was presented for the determination of methamphetamine (METH). The aptasensor exhibited excellent repeatability, selectivity, and the ability to effectively detect METH in spiked urine samples.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Cem Erkmen, Gozde Aydogdu Tig, Bengi Uslu
Summary: In this study, an aptamer-based electrochemical impedance spectroscopy method was developed for the determination of leptin. The aptasensor showed high sensitivity and stability, making it a promising platform for the detection of leptin in human serum and plasma samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Food Science & Technology
Yujiao Hou, Nan Long, Boyu Jia, Xiaofang Liao, Minghan Yang, Lizhu Fu, Lidong Zhou, Ping Sheng, Weijun Kong
Summary: This study developed a conveniently fabricated label-free electrochemical aptasensor for ultrasensitive detection of ochratoxin A (OTA) in food. The aptasensor showed high sensitivity and specificity, with a linear relationship between resistance and OTA concentration. The sensor exhibited promising practical applications in food control for identifying hazardous contaminants.
Article
Nanoscience & Nanotechnology
Yarong Wang, Xueling Yan, Qiming Kou, Qi Sun, Yuexin Wang, Ping Wu, Lulan Yang, Jiaming Tang, Tao Le
Summary: The label-free fluorescent aptasensor developed in this study is a promising tool for rapid and sensitive detection and quantification of SMZ in water and soil samples, showing good sensitivity and linear detection range.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Analytical
Xiaoyan Li, Natashya Falcone, M. Nur Hossain, Heinz-Bernhard Kraatz, Xiaojun Chen, He Huang
Summary: A novel label-free impedimetric electrochemical sensor was proposed for the detection of OTA in food products. The sensor achieved signal amplification by introducing RecJf exonuclease, showing promising potential for application in the food industry.
Article
Chemistry, Analytical
Xiujuan Qiao, Xin Ma, Xiaoyu Ma, Tianli Yue, Qinglin Sheng
Summary: The research showed that an ultrasensitive label-free aptasensor for ochratoxin A (OTA) detection was developed based on 2D MOF nanosheets, showing excellent performance with low detection limit, wide linear range, and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Beibei Xie, Haibo Peng, Ruixue Zhang, Chenhui Wang, Yun He
Summary: A new ultrasensitive electrochemical aptasensor was developed for detecting tetracycline (TET) residue, with a larger linear range and lower detection limit than previous sensors. The new material NCA@SL-AuNPs also exhibited excellent performance in detecting TET in milk.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Yesim Tugce Yaman, Gulcin Bolat, Turkan Busra Saygin, Serdar Abaci
Summary: The study reported the fabrication of a molecularly imprinted overoxidized polypyrrole MIP(oPPy) on graphene oxide (GO) modified single-use pencil graphite electrode (PGE) for the quantitative analysis of the food processing contaminant 3-MCPD. Through optimizing experimental conditions, the research achieved superior recognition performance for 3-MCPD, indicating significant promise for future food safety control applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou
Summary: In this study, a fluorescence and surface-enhanced Raman scattering dual-mode aptasensor was developed for sensitive and rapid detection of Ochratoxin A (OTA). The aptasensor demonstrated low detection limits in both FL and SERS modes, as well as high specificity and good interferent resistance. It showed great potential for OTA detection in coffee and wine samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Food Science & Technology
Zhijun Guo, Jing Tian, Chengbi Cui, Yan Wang, Huanhuan Yang, Ming Yuan, Hansong Yu
Summary: This study demonstrated a new detection system for OTA using fluorescence biosensing based on an anti-OTA aptamer and fluorescence quencher, using single-walled carbon nanohorns. The detection limit of OTA was 2.3 ng/ml with a linear detection range of 5-500 ng/ml. The aptasensor was found suitable for the quantification of OTA in food samples.
Article
Chemistry, Analytical
Sanaz Akbarzadeh, Habibollah Khajehsharifi, Saeedeh Hajihosseini
Summary: A novel, rapid, and label-free aptamer-based electrochemical biosensor was designed for the detection of oxytetracycline (OTC), utilizing a newly synthesized nanocomposite to enhance electrical conductivity of the electrode surface. The aptasensor showed high sensitivity, low detection limit, wide linear range, and good repeatability for measuring OTC content in milk samples. The results demonstrated the effectiveness of the aptasensor in real sample analysis.
Article
Chemistry, Applied
Reza Mahjub, Omid Heydari Shayesteh, Katayoun Derakhshandeh, Akram Ranjbar, Fereshteh Mehri, Ali Heshmati
Summary: In this study, a novel colorimetric bioassay method was developed for the sensitive determination of tobramycin. The method utilizes aptamers and silver nanoparticles to induce aggregation and visible color change in the presence of tobramycin, allowing for quantitative analysis. This method offers high sensitivity and visual detection.
Article
Chemistry, Analytical
Gulcin Bolat, Oznur Akbal Vural, Yesim Tugce Yaman, Serdar Abaci
Summary: A sensor platform using PNT-GO structures for quantification of diabetic nephropathy and cancer-related microRNA-192 was prepared and characterized. The impedance signal was utilized to evaluate hybridization between miRNA-192 and its DNA probe, showing high sensitivity and a wide detection range. Evaluation in peripheral serum samples demonstrated the potential for future clinical and diverse biomedical applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Xiujin Chen, Dong Gao, Jiaqi Chen, Xueqing Wang, Chifang Peng, Hongli Gao, Yao Wang, Zhaozhou Li, Huawei Niu
Summary: In this study, an electrochemical aptasensor using PAMAM dendrimers as a signal amplifier was developed for the sensitive detection of OTA. The aptasensor showed high sensitivity, specificity, and a broad linear detection range with a low detection limit. The proposed aptasensor was successfully applied for OTA analysis in red wine and demonstrated good recovery rates and storage stability.
Review
Biochemical Research Methods
Celia Toyos-Rodriguez, David Valero-Calvo, Alfredo de la Escosura-muniz
Summary: The abusive use of antimicrobial compounds and the associated appearance of antimicrobial resistant strains pose a major threat to human health. Improved antimicrobial administration requires faster diagnosis and detection of resistances. Electrochemical methods used in antimicrobial susceptibility testing (AST), particularly for evaluating new drug candidates, have shown significant potential. The role of nanomaterials in these biosensing platforms is relatively minor compared to other applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Ana Rubio-Monterde, Daniel Quesada-Gonzalez, Arben Merkoci
ANALYTICAL CHEMISTRY
(2023)
Review
Energy & Fuels
Dawid Kasprzak, Carmen C. Mayorga-Martinez, Martin Pumera
Summary: In recent years, there has been a growing demand for advanced wearable electronic gadgets. This review focuses on the research attempts to shift energy storage materials towards sustainable and flexible components. The use of noncellulosic polysaccharides as constituents in composite materials for batteries and supercapacitors is introduced, providing sustainable and flexible substrates for portable power sources.
Article
Multidisciplinary Sciences
Jayraj V. Vaghasiya, Carmen C. Mayorga-Martinez, Jan Vyskocil, Martin Pumera
Summary: The authors developed a black phosphorous-based tactile sensor array system that provides touch sensing and audio feedback. This assistive technology is utilized by visually or speech-disabled individuals to communicate using audio as a platform. The piezoresistive tactile sensor based on a black phosphorous and polyaniline composite showed excellent sensitivity, low-pressure sensitivity, reasonable response time, and good cycle stability. A prototype device using six of these tactile sensors was able to convert pressed text into audio to assist visually or speech-disabled persons.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Lei Zhao, Giulio Rosati, Andrew Piper, Cecilia de Carvalho Castro e Silva, Liming Hu, Qiuyue Yang, Flavio Della Pelle, Ruslan R. Alvarez-Diduk, Arben Merkoci
Summary: Graphene-based materials have unique properties that make them suitable for electro-chemical biosensing. However, the production of graphene electrodes on a large scale remains challenging. This study presents a simple and fast method for fabricating reduced graphene oxide electrodes using direct writing and stamp-transferring techniques. The biosensors developed using these electrodes demonstrated excellent sensitivity and detection limits for Escherichia coli, making them suitable for real-world applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
David Valero-Calvo, Celia Toyos-Rodriguez, Francisco Javier Garcia-Alonso, Alfredo de la Escosura-Muniz
Summary: For the first time, nanoparticles are suggested as carriers of an immobilized enzymatic substrate in nanoporous alumina membranes to enhance nanochannel blocking and improve enzyme determination efficiency. Polystyrene nanoparticles modified with streptavidin are proposed as carrier agents, providing steric and electrostatic blockage due to their charge at different pH values. The effect of using negatively charged and positively charged redox indicator ions on electrostatic blockage is studied for the first time. The approach shows great potential in point-of-care diagnostics with cheap and fast sensing methodology, allowing detection of clinically relevant levels of matrix-metalloproteinase 9 with good reproducibility and selectivity.
Article
Nanoscience & Nanotechnology
Lourdes Rivas, Arben Merkoci, Liming Hu, Claudio Parolo, Andrea Idili
Summary: The use of nanomaterials as colorimetric labels in point-of-care devices can enhance sensitivity. By optimizing the synthesis of gold and iridium oxide nanoflowers, researchers have achieved improved colorimetric signals and sensitivity, making them potential candidates for the next generation of optical lateral flow assays.
ACS APPLIED NANO MATERIALS
(2023)
Review
Engineering, Electrical & Electronic
Jayraj V. Vaghasiya, Carmen C. Mayorga-Martinez, Martin Pumera
Summary: Wearable sensors have made significant progress in sensing physiological and biochemical markers for telehealth, providing enormous potential for early disease detection. Recent advancements in 2D materials-based wearable sensors have introduced a new approach to remote and real-time health monitoring.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Gabriel Maroli, Vernalyn Abarintos, Andrew Piper, Arben Merkoci
Summary: This article reports a method of fabricating nanoband electrodes using low-cost materials and equipment, which have advantages of low cost, fast production, and high flexibility. The research shows that these nanoband electrodes have single molecule sensitivity for the detection of DNA sequences specific to SARS-CoV-2.
Article
Chemistry, Analytical
Ana M. Villa-Manso, Tamara Guerrero-Esteban, Felix Pariente, Celia Toyos-Rodriguez, Alfredo de la Escosura-Muniz, Monica Revenga-Parra, Cristina Gutierrez-Sanchez, Encarnacion Lorenzeo
Summary: A novel immunosensor based on electrochemiluminescence resonance energy transfer (ECL-RET) has been developed for the sensitive determination of N protein of the SARS-CoV-2 coronavirus. The immunosensor utilizes bifunctional core@shell nanoparticles as ECL acceptor and [Ru(bpy)(3)](2+) as ECL donor. It demonstrates a wide linear response to the concentration of N protein with a detection limit of 1.27 pg/mL, high stability, and specificity. The immunosensor has been successfully applied for quantification of N protein in saliva samples and showed consistent results with a commercial colorimetric ELISA kit.
Article
Nanoscience & Nanotechnology
Keval K. Sonigara, Jayraj V. Vaghasiya, Carmen C. Mayorga-Martinez, Martin Pumera
Summary: Flexible aqueous zinc-ion batteries with a Ti3C2Tx decorated sulfur cathode and iodine-added amphiphilic gel electrolyte show high storage capacity, good cycling stability, and excellent mechanical stability. They can power various electronic gadgets and offer promising potential for flexible energy storage technologies.
NPJ 2D MATERIALS AND APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Flavio Della Pelle, Qurat Ul Ain Bukhari, Ruslan Alvarez Diduk, Annalisa Scroccarello, Dario Compagnone, Arben Merkoci
Summary: We introduce a CO2 laser plotter-based technology for the production of heterostructures (HTs) comprising reduced graphene oxide (rGO) and 2D transition metal dichalcogenides (TMDs). The laser treatment converts GO into highly exfoliated and conductive rGO decorated with small TMD/TM-oxide nanoflakes. The freestanding LIHT films obtained exhibit excellent performance as self-contained sensors with nanomolar limits of detection and high fouling resistance.
Article
Chemistry, Multidisciplinary
Yang Qiuyue, Emily P. Nguyen, David Panacek, Veronika Sedajova, Vitezslav Hruby, Giulio Rosati, de Carvalho Castro Silva Cecilia, Aristides Bakandritsos, Michal Otyepka, Arben Merkoci
Summary: Heavy metal pollutants are highly toxic and pose great concern in environmental monitoring. Electrochemical detection, hindered by mutual interferences of heavy metal ions, is a main technique with limited sensitivity to Cd2+ ions. This study introduces a metal-free and sustainable nanomaterial, cysteamine covalently functionalized graphene (GSH), which significantly enhances the sensitivity of screen-printed carbon electrode (SPCE) to Cd2+ ions while maintaining sensitivity to other heavy metals. The enhancement is attributed to the grafted thiols on the GSH sheets with strong affinity to Cd2+ ions, based on Pearson's principle. The GSH-modified SPCE also exhibits high reusability and outperforms existing SPCEs modified by non-covalently functionalized graphene derivatives. The GSH-SPCE is successfully validated in tap water.
Article
Chemistry, Multidisciplinary
Massimo Urban, Giulio Rosati, Gabriel Maroli, Flavio Della Pelle, Andrea Bonini, Laszlo Sajti, Mariangela Fedel, Arben Merkoci
Summary: This study presents a new sintering method called click sintering, which uses a catalytic reaction to enhance and tune the nanostructuration of gold nanoparticle inks. This one-step approach allows for the creation of conductive and electroactive nanoporous thin films without the need for complex post-treatments. The properties of the film can be adjusted by controlling the reaction conditions. The click sintering strategy offers a rapid, easy, and inexpensive technique for fabricating functional nanostructures, with potential applications in flexible electronics, biosensing, energy, and catalysis.
